Complexes of Ibuprofen Thiazolidin-4-One Derivatives with β-Cyclodextrin: Characterization and In Vivo Release Profile and Biological Evaluation.
analgesic assays
ibuprofen derivatives
release profile
β-cyclodextrin
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
19 Oct 2023
19 Oct 2023
Historique:
received:
06
09
2023
revised:
10
10
2023
accepted:
15
10
2023
medline:
28
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Generally, NSAIDs are weakly soluble in water and contain both hydrophilic and hydrophobic groups. One of the most widely used NSAIDs is ibuprofen, which has a poor solubility and high permeability profile. By creating dynamic, non-covalent, water-soluble inclusion complexes, cyclodextrins (CDs) can increase the dissolution rate of low aqueous solubility drugs, operating as a drug delivery vehicle, additionally contributing significantly to the chemical stability of pharmaceuticals and to reducing drug-related irritability. In order to improve the pharmacological and pharmacokinetics profile of ibuprofen, new thiazolidin-4-one derivatives of ibuprofen (
Identifiants
pubmed: 37896252
pii: pharmaceutics15102492
doi: 10.3390/pharmaceutics15102492
pmc: PMC10609741
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Grigore T. Popa University of Medicine and Pharmacy
ID : 30341/28.12.2017
Organisme : Grigore T. Popa University of Medicine and Pharmacy
ID : 10308/29.06.2020
Organisme : Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii
ID : PN-III-P4-ID-PCE-2020-2687 (contract nr. 244/2021
Organisme : Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii
ID : PNIII-P4-ID-PCE-1523 (contract nr. 161/2021)
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