Higher HIV-1 Env gp120-Specific Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity Is Associated with Lower Levels of Defective HIV-1 Provirus.
CS-IPDA
HIV envelope (Env)
HIV provirus
HIV reservoir
HIV-1
antibody
antibody-dependent cellular cytotoxicity (ADCC)
defective provirus
intact provirus
pediatric HIV
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
06 10 2023
06 10 2023
Historique:
received:
11
09
2023
revised:
03
10
2023
accepted:
03
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that persist during antiretroviral therapy (ART), with reservoir size associated with adverse health outcomes and inversely with time to viral rebound upon ART cessation. Once established during ART, the HIV reservoir decays minimally over time; thus, understanding factors that impact the size of the HIV reservoir near its establishment is key to improving the health of people living with HIV and for the development of novel cure strategies. Yet, to date, few correlates of HIV reservoir size have been identified, particularly in pediatric populations. Here, we employed a cross-subtype intact proviral DNA assay (CS-IPDA) to quantify HIV provirus between one- and two-years post-ART initiation in a cohort of Kenyan children (n = 72), which had a median of 99 intact (range: 0-2469), 1340 defective (range: 172-3.84 × 10
Identifiants
pubmed: 37896832
pii: v15102055
doi: 10.3390/v15102055
pmc: PMC10611199
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT00194545']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI076105
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD094718
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI027757
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015704
Pays : United States
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