Generation of a DSF-Guided Refolded Bacterially Expressed Hemagglutinin Ectodomain of Influenza Virus A/Puerto Rico/8/1934 H1N1 as a Model for Influenza Vaccine Antigens.
differential scanning fluorimetry
hemagglutinin
influenza
recombinant protein expression
vaccine
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
24 Sep 2023
24 Sep 2023
Historique:
received:
21
08
2023
revised:
15
09
2023
accepted:
21
09
2023
medline:
28
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Influenza virus infections represent an ongoing public health threat as well as an economic burden. Although seasonal influenza vaccines have been available for some decades, efforts are being made to generate new efficient, flexible, and cost-effective technologies to be transferred into production. Our work describes the development of a model influenza hemagglutinin antigen that is capable of inducing protection against viral challenge in mice. High amounts of the H1 hemagglutinin ectodomain, HA
Identifiants
pubmed: 37896924
pii: vaccines11101520
doi: 10.3390/vaccines11101520
pmc: PMC10610769
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerul Cercetării și Inovării
ID : PN-III-P1-1.2-PCCDI-2017-0529 / 62PCCDI ⁄ 2018
Organisme : Ministerul Cercetării și Inovării
ID : 25N/2023, project PN 23 44 01 01
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