Local recurrence and metachronous multiple cancers after transoral nonrobotic surgery for pharyngeal and laryngeal squamous cell carcinoma: A retrospective multicenter study.
local recurrence
metachronous multiple cancers
multi-institutional retrospective study
nonrobotic surgery
transoral surgery
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
revised:
25
09
2023
received:
08
08
2023
accepted:
17
10
2023
pubmed:
28
10
2023
medline:
28
10
2023
entrez:
28
10
2023
Statut:
ppublish
Résumé
Late laryngopharyngeal cancers after transoral surgery include not only local recurrences but also metachronous multiple cancers. We compared clinical information, surgical outcomes, and late laryngopharyngeal cancers in patients who underwent transoral nonrobotic surgery for laryngopharyngeal squamous cell carcinoma without lymph node metastases between 2015 and 2021 in a multicenter retrospective study. Four hundred and fifty-seven patients were included. Positive surgical margins were found in 121 patients (26.5%). Twenty-two patients (4.8%) received additional treatment. Positive horizontal margins of invasive carcinoma (p = 0.003) and positive horizontal margins of carcinoma in situ only (p = 0.032) were independent risk factors for local recurrence, and prior radiotherapy (p = 0.001) for metachronous multiple cancers. Local control was significantly worse without additional treatment (p = 0.049), but there was no significant difference in survival. Patients with positive margins had an increased frequency of local recurrence, but salvage therapy was effective.
Sections du résumé
BACKGROUND
BACKGROUND
Late laryngopharyngeal cancers after transoral surgery include not only local recurrences but also metachronous multiple cancers.
METHODS
METHODS
We compared clinical information, surgical outcomes, and late laryngopharyngeal cancers in patients who underwent transoral nonrobotic surgery for laryngopharyngeal squamous cell carcinoma without lymph node metastases between 2015 and 2021 in a multicenter retrospective study.
RESULTS
RESULTS
Four hundred and fifty-seven patients were included. Positive surgical margins were found in 121 patients (26.5%). Twenty-two patients (4.8%) received additional treatment. Positive horizontal margins of invasive carcinoma (p = 0.003) and positive horizontal margins of carcinoma in situ only (p = 0.032) were independent risk factors for local recurrence, and prior radiotherapy (p = 0.001) for metachronous multiple cancers. Local control was significantly worse without additional treatment (p = 0.049), but there was no significant difference in survival.
CONCLUSIONS
CONCLUSIONS
Patients with positive margins had an increased frequency of local recurrence, but salvage therapy was effective.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
118-128Informations de copyright
© 2023 Wiley Periodicals LLC.
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