SorCS2 binds progranulin to regulate motor neuron development.

Mice Animals Progranulins Zebrafish / metabolism Intercellular Signaling Peptides and Proteins Motor Neurons / metabolism Granulins Mice, Knockout Nerve Tissue Proteins / metabolism Receptors, Cell Surface / metabolism
CP: Developmental biology CP: Neuroscience SorCS2 VPS10p-D receptors image segmentation light-sheet microscopy motor neurons nerve injury neurodevelopment neurotrophic signaling progranulin zebrafish

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
28 Nov 2023
Historique:
received: 28 04 2022
revised: 25 07 2023
accepted: 09 10 2023
medline: 4 12 2023
pubmed: 29 10 2023
entrez: 28 10 2023
Statut: ppublish

Résumé

Motor neuron (MN) development and nerve regeneration requires orchestrated action of a vast number of molecules. Here, we identify SorCS2 as a progranulin (PGRN) receptor that is required for MN diversification and axon outgrowth in zebrafish and mice. In zebrafish, SorCS2 knockdown also affects neuromuscular junction morphology and fish motility. In mice, SorCS2 and PGRN are co-expressed by newborn MNs from embryonic day 9.5 until adulthood. Using cell-fate tracing and nerve segmentation, we find that SorCS2 deficiency perturbs cell-fate decisions of brachial MNs accompanied by innervation deficits of posterior nerves. Additionally, adult SorCS2 knockout mice display slower motor nerve regeneration. Interestingly, primitive macrophages express high levels of PGRN, and their interaction with SorCS2-positive motor axon is required during axon pathfinding. We further show that SorCS2 binds PGRN to control its secretion, signaling, and conversion into granulins. We propose that PGRN-SorCS2 signaling controls MN development and regeneration in vertebrates.

Identifiants

DOI: 10.1016/j.celrep.2023.113333 PMID: 37897724
pubmed: 37897724
pii: S2211-1247(23)01345-1
doi: 10.1016/j.celrep.2023.113333
pii:
doi:

Substances chimiques

Progranulins 0
Intercellular Signaling Peptides and Proteins 0
Granulins 0
SorCS2 protein, mouse 0
Nerve Tissue Proteins 0
Receptors, Cell Surface 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113333

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Pernille Bogetofte Thomasen (PB)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

Alena Salasova (A)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark. Electronic address: alena.salasova@biomed.au.dk.

Kasper Kjaer-Sorensen (K)

Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.

Lucie Woloszczuková (L)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

Josef Lavický (J)

Department of Histology and Embryology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.

Hande Login (H)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

Jeppe Tranberg-Jensen (J)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

Sergio Almeida (S)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

Sander Beel (S)

Department of Neurology and Department of Neurosciences, KU Leuven and Center for Brain & Disease Research VIB, 3000 Leuven, Belgium.

Michaela Kavková (M)

Department of Histology and Embryology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.

Per Qvist (P)

Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

Mads Kjolby (M)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

Peter Lund Ovesen (PL)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

Stella Nolte (S)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

Benedicte Vestergaard (B)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

Andreea-Cornelia Udrea (AC)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

Lene Niemann Nejsum (LN)

Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark.

Moses V Chao (MV)

Department of Neuroscience and Physiology, NYU Langone Health, New York, NY 10016, USA.

Philip Van Damme (P)

Department of Neurology and Department of Neurosciences, KU Leuven and Center for Brain & Disease Research VIB, 3000 Leuven, Belgium.

Jan Krivanek (J)

Department of Histology and Embryology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.

Jeremy Dasen (J)

Department of Neuroscience and Physiology, NYU Langone Health, New York, NY 10016, USA.

Claus Oxvig (C)

Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.

Anders Nykjaer (A)

Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Center of Excellence PROMEMO, 8000 Aarhus C, Denmark; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark. Electronic address: an@biomed.au.dk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › SorCS2 binds progranulin to regulate motor...
questionsmedicales.fr › Eucaryotes › Animaux › SorCS2 binds progranulin to regulate motor...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Progranulines › SorCS2 binds progranulin to regulate motor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › SorCS2 binds progranulin to regulate motor...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › SorCS2 binds progranulin to regulate motor...
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › SorCS2 binds progranulin to regulate motor...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Progranulines › Granulines › SorCS2 binds progranulin to regulate motor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › SorCS2 binds progranulin to regulate motor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › SorCS2 binds progranulin to regulate motor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › SorCS2 binds progranulin to regulate motor...