'I am afraid you will see the stain on my soul': Direct gaze neural processing in individuals with PTSD after moral injury recall.

Humans Stress Disorders, Post-Traumatic Coloring Agents Emotions / physiology Mental Recall / physiology Myocardial Infarction Magnetic Resonance Imaging
direct gaze fMRI moral injury post-traumatic stress disorder

Journal

Social cognitive and affective neuroscience
ISSN: 1749-5024
Titre abrégé: Soc Cogn Affect Neurosci
Pays: England
ID NLM: 101288795

Informations de publication

Date de publication:
26 Oct 2023
Historique:
received: 21 04 2023
revised: 20 07 2023
accepted: 19 10 2023
medline: 30 10 2023
pubmed: 29 10 2023
entrez: 28 10 2023
Statut: ppublish

Résumé

Direct eye contact is essential to understanding others' thoughts and feelings in social interactions. However, those with post-traumatic stress disorder (PTSD) and exposure to moral injury (MI) may exhibit altered theory-of-mind (ToM)/mentalizing processes and experience shame which precludes one's capacity for direct eye contact. We investigated blood oxygenation level-dependent (BOLD) responses associated with direct vs averted gaze using a virtual reality paradigm in individuals with PTSD (n = 28) relative to healthy controls (n = 18) following recall of a MI vs a neutral memory. Associations between BOLD responses and clinical symptomatology were also assessed. After MI recall, individuals with PTSD showed greater activation in the right temporoparietal junction as compared to controls (T = 4.83; pFDR < 0.001; k = 237) during direct gaze. No significant activation occurred during direct gaze after neutral memory recall. Further, a significant positive correlation was found between feelings of distress and right medial superior frontal gyrus activation in individuals with PTSD (T = 5.03; pFDR = 0.049; k = 123). These findings suggest that direct gaze after MI recall prompts compensatory ToM/mentalizing processing. Implications for future interventions aimed at mitigating the effects of PTSD on social functioning are discussed.

Identifiants

DOI: 10.1093/scan/nsad053 PMID: 37897804 PMC: PMC10612569
pubmed: 37897804
pii: 7332199
doi: 10.1093/scan/nsad053
pmc: PMC10612569
pii:
doi:

Substances chimiques

Coloring Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Canada Foundation for Innovation
ID : 31724
Organisme : Canadian Institute for Military and Veteran Health Research
Organisme : The Centre of Excellence on PTSD
Organisme : Green Shield Canada
Organisme : Institute of Neurosciences, Mental Health and Addiction
ID : 148784
Organisme : Canada Foundation for Innovation
ID : 31724
Organisme : Canadian Institute for Military and Veteran Health Research
Organisme : The Centre of Excellence on PTSD
Organisme : Green Shield Canada
Organisme : Institute of Neurosciences, Mental Health and Addiction
ID : 148784

Informations de copyright

© The Author(s) 2023. Published by Oxford University Press.

Références

Soc Cogn Affect Neurosci. 2020 Nov 6;15(9):905-928
pubmed: 32888303
Depress Anxiety. 2017 Mar 29;:
pubmed: 28370818
Clin Psychol Sci. 2015 Jun 1;3(4):487-502
pubmed: 26167422
J Clin Psychol. 2018 Dec;74(12):2203-2218
pubmed: 29984839
Am J Psychiatry. 2010 Jun;167(6):640-7
pubmed: 20360318
Hum Brain Mapp. 2017 Nov;38(11):5551-5561
pubmed: 28836726
Br J Psychiatry. 2018 Jun;212(6):339-346
pubmed: 29786495
Neuroimage. 2006 May 15;31(1):440-57
pubmed: 16466680
Borderline Personal Disord Emot Dysregul. 2014 Nov 25;1:17
pubmed: 26401301
Child Maltreat. 2018 Feb;23(1):44-53
pubmed: 28705086
Nat Rev Neurosci. 2011 Jun 15;12(7):425; author reply 425
pubmed: 21673722
Hum Brain Mapp. 2018 Aug;39(8):3354-3374
pubmed: 29667267
Neuron. 2006 Apr 20;50(2):329-39
pubmed: 16630842
J Affect Disord. 2013 May;147(1-3):72-9
pubmed: 23141670
Brain Behav. 2014 May;4(3):381-9
pubmed: 24944867
Nat Rev Neurosci. 2005 Oct;6(10):766-74
pubmed: 16276354
Clin Psychol Rev. 2009 Dec;29(8):695-706
pubmed: 19683376
J Trauma Stress. 2019 Jun;32(3):350-362
pubmed: 30688367
Psychol Rev. 2009 Jan;116(1):252-82
pubmed: 19159156
Neuropsychologia. 2016 Sep;90:210-34
pubmed: 27444881
Neuropsychologia. 2007 Oct 1;45(13):3024-37
pubmed: 17644145
J Neurosci. 2007 Feb 28;27(9):2349-56
pubmed: 17329432
Sci Rep. 2019 Jul 31;9(1):11110
pubmed: 31366954
Biol Mood Anxiety Disord. 2012 May 18;2:9
pubmed: 22738125
Soc Sci Med. 2009 Oct;69(7):1032-9
pubmed: 19695754
Neurosci Biobehav Rev. 2020 May;112:164-212
pubmed: 31996300
Psychol Trauma. 2018 Jan;10(1):36-45
pubmed: 28581315
Neuropsychologia. 2008;46(9):2423-30
pubmed: 18402988
Philos Trans R Soc Lond B Biol Sci. 2011 Jun 12;366(1571):1660-70
pubmed: 21536552
Neuroimage. 2005 Jan 1;24(1):235-43
pubmed: 15588615
J Trauma Stress. 2005 Jun;18(3):221-31
pubmed: 16281216
Clin Child Fam Psychol Rev. 2014 Mar;17(1):19-40
pubmed: 23712881
Front Psychiatry. 2022 Jul 13;13:906945
pubmed: 35911220
Acta Psychiatr Scand. 2011 Nov;124(5):331-48
pubmed: 21854369
J Cogn Neurosci. 2004 Apr;16(3):479-86
pubmed: 15072682
Psychophysiology. 2009 Sep;46(5):922-31
pubmed: 19470127
Eur J Neurosci. 2017 Jan;45(2):312-320
pubmed: 27813194
Hum Brain Mapp. 2009 Mar;30(3):829-58
pubmed: 18381770
Hum Brain Mapp. 2015 Dec;36(12):5137-54
pubmed: 26419890
Curr Opin Psychol. 2017 Apr;14:109-115
pubmed: 28813307
Med Hypotheses. 2019 Jul;128:33-42
pubmed: 31203906
Trends Cogn Sci. 2009 Mar;13(3):127-34
pubmed: 19217822
Acta Psychiatr Scand. 2014 Mar;129(3):193-201
pubmed: 23662597
Mil Med. 2013 Jun;178(6):646-52
pubmed: 23756071
J Clin Med. 2016 Nov 01;5(11):
pubmed: 27809274
Neurosci Biobehav Rev. 2014 May;42:9-34
pubmed: 24486722
Neuroimage. 2016 Jan 1;124(Pt A):248-255
pubmed: 26348560
Am J Psychiatry. 1994 Aug;151(8):1132-6
pubmed: 8037246
Psychol Aging. 2002 Dec;17(4):677-89
pubmed: 12507363
Depress Anxiety. 2021 Jun;38(6):596-605
pubmed: 33369799
Curr Biol. 2005 Sep 6;15(17):R644-6
pubmed: 16139190
Brain Struct Funct. 2010 Jun;214(5-6):655-67
pubmed: 20512370
Neuroimage. 2014 Feb 1;86:554-72
pubmed: 24076206
Biol Psychol. 2011 Sep;88(1):124-30
pubmed: 21782881
Trends Cogn Sci. 2013 Jul;17(7):328-36
pubmed: 23790322
Psychol Sci. 2010 Jul;21(7):901-7
pubmed: 20534779
Soc Cogn Affect Neurosci. 2014 Jan;9(1):88-97
pubmed: 22977200
Neurosci Biobehav Rev. 2011 Jan;35(3):903-11
pubmed: 20974173
Soc Cogn Affect Neurosci. 2006 Dec;1(3):229-34
pubmed: 18985110
Neurosci Biobehav Rev. 2007;31(4):585-96
pubmed: 17418416
Neuroimage. 2011 Apr 15;55(4):1593-9
pubmed: 21256220
Neuropharmacology. 2012 Feb;62(2):686-94
pubmed: 21349277
J Psychiatry Neurosci. 2022 Feb 17;47(1):E56-E66
pubmed: 35177485
Brain Behav. 2016 Sep 20;6(12):e00579
pubmed: 28032002
Nat Rev Neurosci. 2002 Aug;3(8):655-66
pubmed: 12154366
Neuroimage. 2006 Oct 15;33(1):127-38
pubmed: 16904911
J Trauma Stress. 2010 Oct;23(5):653-6
pubmed: 20848618
Genes Brain Behav. 2019 Jan;18(1):e12518
pubmed: 30221467
Soc Cogn Affect Neurosci. 2012 Apr;7(4):413-22
pubmed: 21515639

Auteurs

Krysta Andrews (K)

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON L8N 3K7, Canada.
Homewood Research Institute, Guelph, ON N1E 6K9, Canada.

Chantelle S Lloyd (CS)

Homewood Research Institute, Guelph, ON N1E 6K9, Canada.
Department of Psychiatry, Western University, London, ON N6C 0A7, Canada.
Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, ON L8S 4K1, Canada.

Maria Densmore (M)

Department of Psychiatry, Western University, London, ON N6C 0A7, Canada.
Imaging Division, Lawson Health Research Institute, London, ON N6A 4V2, Canada.

Breanne E Kearney (BE)

Department of Neuroscience, Western University, London, ON N6A 3K7, Canada.

Sherain Harricharan (S)

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON L8N 3K7, Canada.

Margaret C McKinnon (MC)

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON L8N 3K7, Canada.
Homewood Research Institute, Guelph, ON N1E 6K9, Canada.
Mood Disorders Program, St. Joseph's Healthcare Hamilton, Hamilton, ON L8N 3K7, Canada.

Jean Théberge (J)

Department of Psychiatry, Western University, London, ON N6C 0A7, Canada.
Imaging Division, Lawson Health Research Institute, London, ON N6A 4V2, Canada.
Department of Medical Biophysics, Western University, London, ON N6A 5C1, Canada.

Rakesh Jetly (R)

Canadian Forces, Health Services, Ottawa, ON K1A 0S2, Canada.
Department of Psychiatry, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Ruth A Lanius (RA)

Homewood Research Institute, Guelph, ON N1E 6K9, Canada.
Department of Psychiatry, Western University, London, ON N6C 0A7, Canada.
Imaging Division, Lawson Health Research Institute, London, ON N6A 4V2, Canada.
Department of Neuroscience, Western University, London, ON N6A 3K7, Canada.
ORCID: 0000-0002-3758-1393

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 'I am afraid you will see the stain on my...
questionsmedicales.fr › Troubles mentaux › Troubles liés aux traumatismes et au stress › Troubles de stress traumatique › Troubles de stress post-traumatique › 'I am afraid you will see the stain on my...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents colorants › 'I am afraid you will see the stain on my...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › 'I am afraid you will see the stain on my...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Rappel mnésique › 'I am afraid you will see the stain on my...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › 'I am afraid you will see the stain on my...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › 'I am afraid you will see the stain on my...