Macromolecular crowding: Sensing without a sensor.
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
23
08
2023
revised:
28
09
2023
accepted:
01
10
2023
medline:
11
12
2023
pubmed:
29
10
2023
entrez:
28
10
2023
Statut:
ppublish
Résumé
All living cells are crowded with macromolecules. Crowding can directly modulate biochemical reactions to various degrees depending on the sizes, shapes, and binding affinities of the reactants. Here, we explore the possibility that cells can sense and adapt to changes in crowding through the widespread modulation of biochemical reactions without the need for a dedicated sensor. Additionally, we explore phase separation as a general physicochemical response to changes in crowding, and a mechanism to both transduce information and physically restore crowding homeostasis.
Identifiants
pubmed: 37897928
pii: S0955-0674(23)00118-7
doi: 10.1016/j.ceb.2023.102269
pii:
doi:
Substances chimiques
Macromolecular Substances
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102269Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.