Bcl-B: an "unknown" protein of the Bcl-2 family.
Bcl-2 family proteins
Bcl-B/Bcl-2L10
Carcinogenesis
Embryogenesis
Oogenesis
Programmed cell death
Journal
Biology direct
ISSN: 1745-6150
Titre abrégé: Biol Direct
Pays: England
ID NLM: 101258412
Informations de publication
Date de publication:
30 10 2023
30 10 2023
Historique:
received:
19
10
2023
accepted:
23
10
2023
medline:
31
10
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
epublish
Résumé
Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different cancer types. In this mini-review, we elucidate the functions of Bcl-B in normal conditions and various pathologies, its regulation of programmed cell death, its oncogene/oncosuppressor activity in tumorigenesis, its impact on drug-acquired resistance, and possible approaches to inhibit Bcl-B.
Identifiants
pubmed: 37899453
doi: 10.1186/s13062-023-00431-4
pii: 10.1186/s13062-023-00431-4
pmc: PMC10614328
doi:
Substances chimiques
Proto-Oncogene Proteins c-bcl-2
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
69Informations de copyright
© 2023. The Author(s).
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