Adult neurogenesis research in China.
Alzheimer's disease
China
adult neurogenesis
depression
neural stem cells
Journal
Development, growth & differentiation
ISSN: 1440-169X
Titre abrégé: Dev Growth Differ
Pays: Japan
ID NLM: 0356504
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
22
10
2023
received:
16
09
2023
accepted:
25
10
2023
medline:
11
12
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
ppublish
Résumé
Neural stem cells are multipotent stem cells that generate functional newborn neurons through a process called neurogenesis. Neurogenesis in the adult brain is tightly regulated and plays a pivotal role in the maintenance of brain function. Disruption of adult neurogenesis impairs cognitive function and is correlated with numerous neurologic disorders. Deciphering the mechanisms underlying adult neurogenesis not only advances our understanding of how the brain functions, but also offers new insight into neurologic diseases and potentially contributes to the development of effective treatments. The field of adult neurogenesis is experiencing significant growth in China. Chinese researchers have demonstrated a multitude of factors governing adult neurogenesis and revealed the underlying mechanisms of and correlations between adult neurogenesis and neurologic disorders. Here, we provide an overview of recent advancements in the field of adult neurogenesis due to Chinese scientists.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
534-545Subventions
Organisme : STI2030-Major Projects
ID : 2021ZD0202302
Organisme : The National Key Research and Development Program of China
ID : 2019YFA0802100
Organisme : the National Science Foundation of China
ID : 31921002
Organisme : the National Science Foundation of China
ID : 82271202
Informations de copyright
© 2023 Japanese Society of Developmental Biologists.
Références
Altman, J. (1962). Are new neurons formed in the brains of adult mammals? Science, 135(3509), 1127-1135. https://doi.org/10.1126/science.135.3509.1127
Altman, J., & Das, G. D. (1965). Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. The Journal of Comparative Neurology, 124(3), 319-335. https://doi.org/10.1002/cne.901240303
Becker, S., & Wojtowicz, J. M. (2007). A model of hippocampal neurogenesis in memory and mood disorders. Trends in Cognitive Sciences, 11(2), 70-76. https://doi.org/10.1016/j.tics.2006.10.013
Ben Abdallah, N. M. B., Slomianka, L., & Lipp, H. P. (2007). Reversible effect of X-irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice. Hippocampus, 17(12), 1230-1240. https://doi.org/10.1002/hipo.20358
Berg, D. A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Ringeling, F. R., Jain, R., Epstein, J. A., Wu, Q. F., Canzar, S., Ming, G. L., Song, H., & Bond, A. M. (2019). A common embryonic origin of stem cells drives developmental and adult neurogenesis. Cell, 177(3), 654-668. https://doi.org/10.1016/j.cell.2019.02.010
Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., Hen, R., & Mann, J. J. (2018). Human hippocampal neurogenesis persists throughout aging. Cell Stem Cell, 22(4), 589-599. https://doi.org/10.1016/j.stem.2018.03.015
Bond, A. M., Ming, G. L., & Song, H. J. (2015). Adult mammalian neural stem cells and neurogenesis: Five decades later. Cell Stem Cell, 17(4), 385-395. https://doi.org/10.1016/j.stem.2015.09.003
Cao, X., Li, L. P., Qin, X. H., Li, S. J., Zhang, M., Wang, Q., Hu, H. H., Fang, Y. Y., Gao, Y. B., Li, X. W., Sun, L. R., Xiong, W. C., Gao, T. M., & Zhu, X. H. (2013). Astrocytic adenosine 5′-triphosphate release regulates the proliferation of neural stem cells in the adult hippocampus. Stem Cells, 31(8), 1633-1643. https://doi.org/10.1002/stem.1408
Cao, Y. H., Zhuang, Y. L., Chen, J. C., Xu, W. Z., Shou, Y. K., Huang, X. L., Shu, Q., & Li, X. K. (2020). Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice. Human Molecular Genetics, 29(5), 727-735. https://doi.org/10.1093/hmg/ddz274
Ceni, C., Unsain, N., Zeinieh, M. P., & Barker, P. A. (2014). Neurotrophins in the regulation of cellular survival and death. Handbook of Experimental Pharmacology, 220, 193-221. https://doi.org/10.1007/978-3-642-45106-5_8
Chai, G. S., Wang, Y. Y., Yasheng, A., & Zhao, P. (2016). Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice. Neural Regeneration Research, 11(10), 1617-1624. https://doi.org/10.4103/1673-5374.193241
Chen, F., Yu, X. B., Meng, G. L., Mei, Z. L., Du, Y. F., Sun, H. B., Reed, M. N., Kong, L. Y., Suppiramaniam, V., Hong, H., & Tang, S. S. (2019). Hippocampal genetic knockdown of PPAR delta causes depression-like behaviors and neurogenesis suppression. International Journal of Neuropsychopharmacology, 22(6), 372-382. https://doi.org/10.1093/ijnp/pyz008
Chen, J. C., Dong, X. X., Cheng, X. J., Zhu, Q., Zhang, J. Y., Li, Q., Huang, X. L., Wang, M., Li, L. P., Guo, W. X., Sun, B. G., Shu, Q., Yi, W., & Li, X. K. (2021). Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating notch signaling. Cell Reports, 34(13), 108905. https://doi.org/10.1016/j.celrep.2021.108905
Chen, J. C., Zhang, Y. C., Huang, C. M., Shen, H., Sun, B. F., Cheng, X. J., Zhang, Y. J., Yang, Y. G., Shu, Q., Yang, Y., & Li, X. K. (2019). M(6)a regulates neurogenesis and neuronal development by modulating histone methyltransferase Ezh2. Genomics, Proteomics & Bioinformatics, 17(2), 154-168. https://doi.org/10.1016/j.gpb.2018.12.007
Chen, W. W., Fu, W. Y., Su, Y. T., Fang, W. Q., Fu, A. K. Y., & Ip, N. Y. (2019). Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect. Scientific Reports, 9, 1190. https://doi.org/10.1038/s41598-018-38103-3
Chi, S. P., Cui, Y. X., Wang, H. P., Jiang, J. H., Zhang, T. X., Sun, S. H., Zhou, Z., Zhong, Y., & Xiao, B. L. (2022). Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions. Neuron, 111(18), 2984. https://doi.org/10.1016/j.neuron.2022.07.010
Cope, E., & Gould, E. (2019). Adult neurogenesis, glia, and the extracellular matrix. Cell Stem Cell, 24(5), 690-705. https://doi.org/10.1016/j.stem.2019.03.023
Dai, Y., Sun, F. F., Zhu, H., Liu, Q. Q., Xu, X. D., Gong, P. P., Jiang, R., Jin, G. H., Qin, J. B., Chen, J., Zhang, X. H., & Shi, W. (2019). Effects and mechanism of action of neonatal versus adult astrocytes on neural stem cell proliferation after traumatic brain injury. Stem Cells, 37(10), 1344-1356. https://doi.org/10.1002/stem.3060
Del Bigio, M. R. (2010). Ependymal cells: Biology and pathology. Acta Neuropathologica, 119(1), 55-73. https://doi.org/10.1007/s00401-009-0624-y
Dong, J., Pan, Y. B., Wu, X. R., He, L. N., Liu, X. D., Feng, D. F., Sun, S. Y., Xu, N. J., & Xu, T. L. (2019). A neuronal molecular switch through cell-cell contact that regulates quiescent neural stem cells. Science Advances, 5(2), eaav4416. https://doi.org/10.1126/sciadv.aav4416
Du, K. Z., Zhang, L. B., Lee, T., & Sun, T. (2019). M(6)a RNA methylation controls neural development and is involved in human diseases. Molecular Neurobiology, 56(3), 1596-1606. https://doi.org/10.1007/s12035-018-1138-1
Du, L. L., Wang, L., Yang, X. F., Wang, P., Li, X. H., Chai, D. M., Liu, B. J., Cao, Y., Xu, W. Q., Liu, R., Tian, Q., Wang, J. Z., & Zhou, X. W. (2017). Transient receptor potential-canonical 1 is essential for environmental enrichment-induced cognitive enhancement and neurogenesis. Molecular Neurobiology, 54(3), 1992-2002. https://doi.org/10.1007/s12035-016-9758-9
Fan, D., Li, J., Zheng, B., Hua, L., & Zuo, Z. Y. (2016). Enriched environment attenuates surgery-induced impairment of learning, memory, and neurogenesis possibly by preserving BDNF expression. Molecular Neurobiology, 53(1), 344-354. https://doi.org/10.1007/s12035-014-9013-1
Fan, G., Martinowich, K., Chin, M. H., He, F., Fouse, S. D., Hutnick, L., Hattori, D., Ge, W., Shen, Y., Wu, H., ten Hoeve, J., Shuai, K., & Sun, Y. E. (2005). DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development, 132(15), 3345-3356. https://doi.org/10.1242/dev.01912
Fuentealba, L. C., Rompani, S. B., Parraguez, J. I., Obernier, K., Romero, R., Cepko, C. L., & Alvarez-Buylla, A. (2015). Embryonic origin of postnatal neural stem cells. Cell, 161(7), 1644-1655. https://doi.org/10.1016/j.cell.2015.05.041
Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y., & Gotoh, Y. (2015). Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells. Nature Neuroscience, 18(5), 657-665. https://doi.org/10.1038/nn.3989
Gage, F. H., & Temple, S. (2013). Neural stem cells: Generating and regenerating the brain. Neuron, 80(3), 588-601. https://doi.org/10.1016/j.neuron.2013.10.037
Gao, H., Cheng, X. J., Chen, J. C., Ji, C., Guo, H. F., Qu, W. Z., Dong, X. X., Chen, Y. Y., Ma, L. H., Shu, Q., & Li, X. K. (2020). Fto-modulated lipid niche regulates adult neurogenesis through modulating adenosine metabolism. Human Molecular Genetics, 29(16), 2775-2787. https://doi.org/10.1093/hmg/ddaa171
Ge, S. Y., Yang, C. H., Hsu, K. S., Ming, G. L., & Song, H. J. (2007). A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron, 54(4), 559-566. https://doi.org/10.1016/j.neuron.2007.05.002
Guo, W. X., Zhang, L., Christopher, D. M., Teng, Z. Q., Fausett, S. R., Liu, C. M., George, O. L., Klingensmith, J., Jin, P., & Zhao, X. Y. (2011). RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing noggin expression. Neuron, 70(5), 924-938. https://doi.org/10.1016/j.neuron.2011.03.027
Guo, Y., Luo, X., & Guo, W. X. (2023). The impact of amino acid metabolism on adult neurogenesis. Biochemical Society Transactions, 51, 233-244. https://doi.org/10.1042/Bst20220762
Guo, Y., Wu, J., Wang, M., Wang, X., Jian, Y., Yang, C., & Guo, W. (2022). The metabolite Saccharopine impairs neuronal development by inhibiting the neurotrophic function of Glucose-6-phosphate isomerase. The Journal of Neuroscience, 42(13), 2631-2646. https://doi.org/10.1523/JNEUROSCI.1459-21.2022
Han, X., Shen, X., Wang, M., Wang, X., Jian, Y., Yang, C., & Guo, W. (2022). Loss of RNA-binding protein HuR leads to defective ependymal cells and hydrocephalus. The Journal of Neuroscience, 42(2), 202-219. https://doi.org/10.1523/JNEUROSCI.1317-21.2021
Hao, Z. Z., Wei, J. R., Xiao, D. C., Liu, R. F., Xu, N. N., Tang, L., Huang, M. Y., Shen, Y. H., Xing, C. S., Huang, W. J., Liu, X. L., Xiang, M. Q., Liu, Y. Z., Miao, Z. C., & Liu, S. (2022). Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations. Nature Neuroscience, 25(6), 805. https://doi.org/10.1038/s41593-022-01073-x
Hardy, J., & Selkoe, D. J. (2002). Medicine-the amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science, 297(5580), 353-356. https://doi.org/10.1126/science.1072994
Hong, X. P., Peng, C. X., Wei, W., Tian, Q., Liu, Y. H., Cao, F. Y., Wang, Q., & Wang, J. Z. (2011). Relationship of adult neurogenesis with tau phosphorylation and GSK-3 beta activity in subventricular zone. Neurochemical Research, 36(2), 288-296. https://doi.org/10.1007/s11064-010-0316-y
Hong, X. P., Peng, C. X., Wei, W., Tian, Q., Liu, Y. H., Yao, X. Q., Zhang, Y., Cao, F. Y., Wang, Q., & Wang, J. Z. (2010). Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus, 20(12), 1339-1349. https://doi.org/10.1002/hipo.20712
Hsieh, J., & Zhao, X. Y. (2016). Genetics and epigenetics in adult neurogenesis. Cold Spring Harbor Perspectives in Biology, 8(6), a018911. https://doi.org/10.1101/cshperspect.a018911
Hu, Z. C., Ma, J., Yue, H. M., Luo, Y. J., Li, X. F., Wang, C., Wang, L., Sun, B. G., Chen, Z., Wang, L., & Gu, Y. (2022). Involvement of LIN28A in Wnt-dependent regulation of hippocampal neurogenesis in the aging brain. Stem Cell Reports, 17(7), 1666-1682. https://doi.org/10.1016/j.stemcr.2022.05.016
Huang, X., Lin, X. H., Liu, F., Wu, G., Yang, Z. Z., & Meng, A. M. (2022). The rise of developmental biology in China. Development Growth Differentiation, 64(2), 106-115. https://doi.org/10.1111/dgd.12751
Hutnick, L. K., Golshani, P., Namihira, M., Xue, Z., Matynia, A., Yang, X. W., Silva, A. J., Schweizer, F. E., & Fan, G. (2009). DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Human Molecular Genetics, 18(15), 2875-2888. https://doi.org/10.1093/hmg/ddp222
Ito, K., & Suda, T. (2014). Metabolic requirements for the maintenance of self-renewing stem cells. Nature Reviews. Molecular Cell Biology, 15(4), 243-256. https://doi.org/10.1038/nrm3772
Jessberger, S., & Parent, J. M. (2015). Epilepsy and adult neurogenesis. Cold Spring Harbor Perspectives in Biology, 7(12), a020677. https://doi.org/10.1101/cshperspect.a020677
Ji, J. F., Ji, S. J., Sun, R., Li, K., Zhang, Y., Zhang, L. Y., & Tian, Y. (2014). Forced running exercise attenuates hippocampal neurogenesis impairment and the neurocognitive deficits induced by whole-brain irradiation via the BDNF-mediated pathway. Biochemical and Biophysical Research Communications, 443(2), 646-651. https://doi.org/10.1016/j.bbrc.2013.12.031
Jia, G. F., Fu, Y., Zhao, X., Dai, Q., Zheng, G. Q., Yang, Y., Yi, C. Q., Lindahl, T., Pan, T., Yang, Y. G., & He, C. (2011). N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chemical Biology, 7(12), 885-887. https://doi.org/10.1038/Nchembio.687
Jia, Y. F., Song, N. N., Mao, R. R., Li, J. N., Zhang, Q., Huang, Y., Zhang, L., Han, H. L., Ding, Y. Q., & Xu, L. (2014). Abnormal anxiety-and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells. Frontiers in Behavioral Neuroscience, 8, 325. https://doi.org/10.3389/fnbeh.2014.00325
Jin, W. N., Shi, K., He, W., Sun, J. H., Van Kaer, L., Shi, F. D., & Liu, Q. (2021). Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition. Nature Neuroscience, 24(1), 61-73. https://doi.org/10.1038/s41593-020-00745-w
Johnsen, S., & Lohmann, K. J. (2008). Magnetoreception in animals. Physics Today, 61(3), 29-35. https://doi.org/10.1063/1.2897947
Kempermann, G. (2019). Environmental enrichment, new neurons and the neurobiology of individuality. Nature Reviews Neuroscience, 20(4), 235-245. https://doi.org/10.1038/s41583-019-0120-x
Klungland, A., & Dahl, J. A. (2014). Dynamic RNA modifications in disease. Current Opinion in Genetics & Development, 26, 47-52. https://doi.org/10.1016/j.gde.2014.05.006
Knobloch, M., & Jessberger, S. (2017). Metabolism and neurogenesis Marlen Knobloch and Sebastian Jessberger. Current Opinion in Neurobiology, 42, 45-52. https://doi.org/10.1016/j.conb.2016.11.006
Kohman, R. A., & Rhodes, J. S. (2013). Neurogenesis, inflammation and behavior. Brain Behavior and Immunity, 27, 22-32. https://doi.org/10.1016/j.bbi.2012.09.003
Kokhan, V. S., Matveeva, M. I., Mukhametov, A., & Shtemberg, A. S. (2016). Risk of defeats in the central nervous system during deep space missions. Neuroscience and Biobehavioral Reviews, 71, 621-632. https://doi.org/10.1016/j.neubiorev.2016.10.006
Kong, X. J., Gong, Z., Zhang, L., Sun, X. D., Ou, Z. R., Xu, B., Huang, J. Y., Long, D. H., He, X. S., Lin, X. H., Li, Q. Q., Xu, L. P., & Xuan, A. G. (2019). JAK2/STAT3 signaling mediates IL-6-inhibited neurogenesis of neural stem cells through DNA demethylation/methylation. Brain Behavior and Immunity, 79, 159-173. https://doi.org/10.1016/j.bbi.2019.01.027
Koppelmans, V., Erdeniz, B., De Dios, Y. E., Wood, S. J., Reuter-Lorenz, P. A., Kofman, I., Bloomberg, J. J., Mulavara, A. P., & Seidler, R. D. (2013). Study protocol to examine the effects of spaceflight and a spaceflight analog on neurocognitive performance: Extent, longevity, and neural bases. BMC Neurology, 13, 205. https://doi.org/10.1186/1471-2377-13-205
Kumar, A., Singh, A., & Ekavali. (2015). A review on Alzheimer's disease pathophysiology and its management: An update. Pharmacological Reports, 67(2), 195-203. https://doi.org/10.1016/j.pharep.2014.09.004
Lazarov, O., & Hollands, C. (2016). Hippocampal neurogenesis: Learning to remember. Progress in Neurobiology, 138, 1-18. https://doi.org/10.1016/j.pneurobio.2015.12.006
Lee, B. E., Suh, P. G., & Kim, J. I. (2021). O-GlcNAcylation in health and neurodegenerative diseases. Experimental and Molecular Medicine, 53(11), 1674-1682. https://doi.org/10.1038/s12276-021-00709-5
Leuner, B., Kozorovitskiy, Y., Gross, C. G., & Gould, E. (2007). Diminished adult neurogenesis in the marmoset brain precedes old age. Proceedings of the National Academy of Sciences of the United States of America, 104(43), 17169-17173. https://doi.org/10.1073/pnas.0708228104
Li, D. B., Tang, J., Xu, H. W., Fan, X. T., Bai, Y., & Yang, L. (2008). Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1 Delta E9 mouse model of Alzheimer's disease. Hippocampus, 18(7), 692-698. https://doi.org/10.1002/hipo.20428
Li, D. P., Ma, S. S., Guo, D. W., Cheng, T., Li, H. W., Tian, Y., Li, J. B., Guan, F. X., Yang, B., & Wang, J. (2021). Environmental circadian disruption worsens neurologic impairment and inhibits hippocampal neurogenesis in adult rats after traumatic brain injury (vol 36, pg 1045, 2016). Cellular and Molecular Neurobiology, 41(3), 615-616. https://doi.org/10.1007/s10571-020-00913-3
Li, H. H., Liu, Y., Chen, H. S., Wang, J., Li, Y. K., Zhao, Y., Sun, R., He, J. G., Wang, F., & Chen, J. G. (2023). PDGF-BB-dependent neurogenesis buffers depressive-like behaviors by inhibition of GABAergic projection from medial septum to dentate gyrus. Advanced Science, 10(22), e2301110. https://doi.org/10.1002/advs.202301110
Li, L. P., Zang, L. Q., Zhang, F. R., Chen, J. C., Shen, H., Shu, L. Q., Liang, F., Feng, C. Y., Chen, D., Tao, H. K., Xu, T. L., Li, Z. Y., Kang, Y. H., Wu, H., Tang, L. C., Zhang, P. M., Jin, P., Shu, Q. A., & Li, X. K. (2017). Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. Human Molecular Genetics, 26(13), 2398-2411. https://doi.org/10.1093/hmg/ddx128
Li, S., Wang, C., Wang, W., Dong, H. P., Hou, P., & Tang, Y. Y. (2008). Chronic mild stress impairs cognition in mice: From brain homeostasis to behavior. Life Sciences, 82(17-18), 934-942. https://doi.org/10.1016/j.lfs.2008.02.010
Li, T., Liu, H., Jiang, D., Yang, K., Shen, J., Feng, H., Wang, S., Zhang, Y., Wang, Y., & Tang, T. S. (2022). BMP4 exerts anti-neurogenic effect via inducing Id3 during aging. Biomedicine, 10(5), 1147. https://doi.org/10.3390/biomedicines10051147
Li, W. P., Su, X. H., Hu, N. Y., Hu, J., Li, X. W., Yang, J. M., & Gao, T. M. (2022). Astrocytes mediate cholinergic regulation of adult hippocampal neurogenesis and memory through M1 muscarinic receptor. Biological Psychiatry, 92(12), 984-998. https://doi.org/10.1016/j.biopsych.2022.04.019
Li, X., Wang, H., Zhang, Q., Sun, X., Zhang, M., & Wang, G. (2023). Inhibition of adult hippocampal neurogenesis induced by postoperative CD8 + T-cell infiltration is associated with cognitive decline later following surgery in adult mice. Journal of Neuroinflammation, 20(1), 227. https://doi.org/10.1186/s12974-023-02910-x
Li, X. K., & Zuo, P. P. (2005). Effects of a beta(25-35) on neurogenesis in the adult mouse subventricular zone and dentate gyrus. Neurological Research, 27(2), 218-222. https://doi.org/10.1179/016164105x35585
Li, Y., & Guo, W. (2021). Neural stem cell niche and adult neurogenesis. The Neuroscientist, 27(3), 235-245. https://doi.org/10.1177/1073858420939034
Liao, R. J., Chen, Y. C., Cheng, L., Fan, L. S., Chen, H., Wan, Y. S., You, Y., Zheng, Y. R., Jiang, L., Chen, Z., Zhang, X., & Hu, W. W. (2019). Histamine H1 receptors in neural stem cells are required for the promotion of neurogenesis conferred by H3 receptor antagonism following traumatic brain injury. Stem Cell Reports, 12(3), 532-544. https://doi.org/10.1016/j.stemcr.2019.01.004
Liu, B., Liu, J., Wang, J. G., Liu, C. L., & Yan, H. J. (2020). AdipoRon improves cognitive dysfunction of Alzheimer's disease and rescues impaired neural stem cell proliferation through AdipoR1/AMPK pathway bin. Experimental Neurology, 327, 113249. https://doi.org/10.1016/j.expneurol.2020.113249
Liu, B. Y., Cheng, W. J., Cheng, D. T., Pu, J., Nie, Z., Xia, C. F., Chen, Y. B., & Yang, C. P. (2021). PirB functions as an intrinsic suppressor in hippocampal neural stem cells. Aging (Albany NY), 13(12), 16062-16071. https://doi.org/10.18632/aging.203134
Liu, D. X., Wang, Z., Gao, Z., Xie, K., Zhang, Q. R., Jiang, H., & Pang, Q. (2014). Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress. Behavioural Brain Research, 271, 116-121. https://doi.org/10.1016/j.bbr.2014.05.068
Liu, F., Tian, N., Zhang, H. Q., Li, S. H., Zhou, Q. Z., Yang, Y., Zheng, J., & Wang, J. Z. (2020). GSK-3beta activation accelerates early-stage consumption of hippocampal neurogenesis in senescent mice. Theranostics, 10(21), 9674-9685. https://doi.org/10.7150/thno.43829
Liu, L., Zhang, Q., Cai, Y. L., Sun, D. Y., He, X., Wang, L., Yu, D., Li, X., Xiong, X. Y., Xu, H. W., Yang, Q. W., & Fan, X. T. (2016). Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis. Oncotarget, 7(35), 56045-56059. https://doi.org/10.18632/oncotarget.11178
Liu, Y., Wang, M., Guo, Y., Wang, L., & Guo, W. (2023). D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase. Cell Reports, 42(2), 112067. https://doi.org/10.1016/j.celrep.2023.112067
Lu, L., Bao, G. B., Chen, H., Xia, P., Fan, X. L., Zhang, J. S., Pei, G., & Ma, L. (2003). Modification of hippocampal neurogenesis and neuroplasticity by social environments. Experimental Neurology, 183(2), 600-609. https://doi.org/10.1016/S0014-4886(03)00248-6
Lu, M., Yang, J. Z., Geng, F., Ding, J. H., & Hu, G. (2014). Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis. International Journal of Neuropsychopharmacology, 17(9), 1501-1510. https://doi.org/10.1017/S1461145714000285
Luo, X., Dai, M., Wang, M., Wang, X., & Guo, W. (2023). Functional heterogeneity of Wnt-responsive and hedgehog-responsive neural stem cells in the murine adult hippocampus. Developmental Cell, 12, S1534-5807(23)00386-6. https://doi.org/10.1016/j.devcel.2023.07.021
Ma, D. K., Jang, M. H., Guo, J. U., Kitabatake, Y., Chang, M. L., Pow-Anpongkul, N., Flavell, R. A., Lu, B., Ming, G. L., & Song, H. (2009). Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science, 323(5917), 1074-1077. https://doi.org/10.1126/science.1166859
Ma, D. K., Ming, G. L., & Song, H. J. (2005). Glial influences on neural stem cell development: cellular niches for adult neurogenesis. Current Opinion in Neurobiology, 15(5), 514-520. https://doi.org/10.1016/j.conb.2005.08.003
Ma, S. H., Sun, R. Q., Jiang, B. W., Gao, J., Deng, W. L., Liu, P., He, R. Y., Cui, J., Ji, M. B., Yi, W., Yang, P. Y., Wu, X. H., Xiong, Y., Qiu, Z. L., Ye, D., & Guan, K. L. (2017). L2hgdh deficiency accumulates L-2-hydroxyglutarate with progressive leukoencephalopathy and neurodegeneration. Molecular and Cellular Biology, 37(8), e00492-16. https://doi.org/10.1128/MCB.00492-16
Malhi, G. S., & Mann, J. J. (2018). Depression. Lancet, 392(10161), 2299-2312. https://doi.org/10.1016/S0140-6736(18)31948-2
Mao, J. X., Huang, S. C., Liu, S. F., Feng, X. L., Yu, M., Liu, J. J., Sun, Y. E., Chen, G. L., Yu, Y., Zhao, J., & Pei, G. (2015). A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation. Aging Cell, 14(5), 784-796. https://doi.org/10.1111/acel.12356
Ming, G. L., & Song, H. J. (2011). Adult neurogenesis in the mammalian brain: Significant answers and significant questions. Neuron, 70(4), 687-702. https://doi.org/10.1016/j.neuron.2011.05.001
Moreno-Jimenez, E. P., Terreros-Roncal, J., Flor-Garcia, M., Rabano, A., & Llorens-Martin, M. (2021). Evidences for adult hippocampal neurogenesis in humans. The Journal of Neuroscience, 41(12), 2541-2553. https://doi.org/10.1523/Jneurosci.0675-20.2020
Mu, Y. L., & Gage, F. H. (2011). Adult hippocampal neurogenesis and its role in Alzheimer's disease. Molecular Neurodegeneration, 6, 85. https://doi.org/10.1186/1750-1326-6-85
Negredo, P. N., Yeo, R. W., & Brunet, A. (2020). Aging and rejuvenation of neural stem cells and their niches. Cell Stem Cell, 27(2), 202-223. https://doi.org/10.1016/j.stem.2020.07.002
Niu, X. J., Zhao, Y. H., Yang, N., Zhao, X. C., Zhang, W., Bai, X. W., Li, A., Yang, W. L., & Lu, L. (2020). Proteasome activation by insulin-like growth factor-1/nuclear factor erythroid 2-related factor 2 signaling promotes exercise-induced neurogenesis. Stem Cells, 38(2), 246-260. https://doi.org/10.1002/stem.3102
Opendak, M., & Gould, E. (2015). Adult neurogenesis: A substrate for experience-dependent change. Trends in Cognitive Sciences, 19(3), 151-161. https://doi.org/10.1016/j.tics.2015.01.001
Ou, Z. R., Kong, X. J., Sun, X. D., He, X. S., Zhang, L., Gong, Z., Huang, J. Y., Xu, B. A., Long, D. H., Li, J. H., Li, Q. Q., Xu, L. P., & Xuan, A. G. (2018). Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice. Brain Behavior and Immunity, 69, 351-363. https://doi.org/10.1016/j.bbi.2017.12.009
Ou-Yang, T. P., Zhu, G. M., Ding, Y. X., Yang, F., Sun, X. L., & Jiang, W. (2016). The effects of amiloride on seizure activity, cognitive deficits and seizure-induced neurogenesis in a novel rat model of febrile seizures. Neurochemical Research, 41(4), 933-942. https://doi.org/10.1007/s11064-015-1777-9
Palinkas, L. A. (2001). Psychosocial issues in long-term space flight: Overview. Gravitational and Space Biology Bulletin, 14(2), 25-33.
Pan, H. Y., Wang, D. P., Zhang, X. Q., Zhou, D. M., Zhang, H., Qian, Q., He, X., Liu, Z. L., Liu, Y. J., Zheng, T. T., Zhang, L., Wang, M. K., & Sun, B. G. (2016). Amyloid beta is not the major factor accounting for impaired adult hippocampal neurogenesis in mice overexpressing amyloid precursor protein. Stem Cell Reports, 7(4), 707-718. https://doi.org/10.1016/j.stemcr.2016.08.019
Pereira, J. D., Sansom, S. N., Smith, J., Dobenecker, M. W., Tarakhovsky, A., & Livesey, F. J. (2010). Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America, 107(36), 15957-15962. https://doi.org/10.1073/pnas.1002530107
Potzsch, A., Zocher, S., Bernas, S. N., Leiter, O., Runker, A. E., & Kempermann, G. (2021). L-lactate exerts a pro-proliferative effect on adult hippocampal precursor cells in vitro. Iscience, 24(2), 102126. https://doi.org/10.1016/j.isci.2021.102126
Qin, T. T., Yuan, Z. Q., Yu, J. Y., Fu, X. X., Deng, X. Y., Fu, Q., Ma, Z. Q., & Ma, S. P. (2020). Saikosaponin-d impedes hippocampal neurogenesis and causes cognitive deficits by inhibiting the survival of neural stem/progenitor cells via neurotrophin receptor signaling in mice. Clinical and Translational Medicine, 10(8), e243. https://doi.org/10.1002/ctm2.243
Rafalski, V. A., & Brunet, A. (2011). Energy metabolism in adult neural stem cell fate. Progress in Neurobiology, 93(2), 182-203. https://doi.org/10.1016/j.pneurobio.2010.10.007
Riquelme, P. A., Drapeau, E., & Doetsch, F. (2008). Brain micro-ecologies: Neural stem cell niches in the adult mammalian brain. Philosophical Transactions of the Royal Society B-Biological Sciences, 363(1489), 123-137. https://doi.org/10.1098/rstb.2006.2016
Sahay, A., & Hen, R. (2007). Adult hippocampal neurogenesis in depression. Nature Neuroscience, 10(9), 1110-1115. https://doi.org/10.1038/nn1969
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., Belzung, C., & Hen, R. (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science, 301(5634), 805-809. https://doi.org/10.1126/science.1083328
Seth, P., & Koul, N. (2008). Astrocyte, the star avatar: Redefined. Journal of Biosciences, 33(3), 405-421. https://doi.org/10.1007/s12038-008-0060-5
Shen, S. Y., Yu, R., Li, W., Liang, L. F., Han, Q. Q., Huang, H. J., Li, B., Xu, S. F., Wu, G. C., Zhang, Y. Q., & Yu, J. (2022). The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice. Neurobiology of Disease, 169, 105743. https://doi.org/10.1016/j.nbd.2022.105743
Sher, F., Rossler, R., Brouwer, N., Balasubramaniyan, V., Boddeke, E., & Copray, S. (2008). Differentiation of neural stem cells into oligodendrocytes: Involvement of the Polycomb group protein Ezh2. Stem Cells, 26(11), 2875-2883. https://doi.org/10.1634/stemcells.2008-0121
Shi, R. X., Liu, C., Xu, Y. J., Wang, Y. Y., He, B. D., He, X. C., Du, H. Z., Hu, B. Y., Jiao, J. W., Liu, C. M., & Teng, Z. Q. (2023). The role and mechanism of transglutaminase 2 in regulating hippocampal neurogenesis after traumatic brain injury. Cell, 12(4), 558. https://doi.org/10.3390/cells12040558
Song, C. G., Xu, W. S., Zhang, X. Q., Wang, S., Zhu, G., Xiao, T., Zhao, M., & Zhao, C. S. (2016). CXCR4 antagonist AMD3100 suppresses the Long-term abnormal structural changes of newborn neurons in the intraventricular kainic acid model of epilepsy. Molecular Neurobiology, 53(3), 1518-1532. https://doi.org/10.1007/s12035-015-9102-9
Song, N. N., Huang, Y., Yu, X., Lang, B., Ding, Y. Q., & Zhang, L. (2017). Divergent roles of central serotonin in adult hippocampal neurogenesis. Frontiers in Cellular Neuroscience, 11, 185. https://doi.org/10.3389/fncel.2017.00185
Song, N. N., Jia, Y. F., Zhang, L., Zhang, Q., Huang, Y., Liu, X. Z., Hu, L., Lan, W., Chen, L., Lesch, K. P., Chen, X., Xu, L., & Ding, Y. Q. (2016). Reducing central serotonin in adulthood promotes hippocampal neurogenesis. Scientific Reports, 6, 20338. https://doi.org/10.1038/srep20338
Song, N. N., Zhang, Q., Huang, Y., Chen, L., Ding, Y. Q., & Zhang, L. (2017). Enhanced dendritic morphogenesis of adult hippocampal newborn neurons in central 5-HT-deficient mice. Stem Cell Research, 19, 6-11. https://doi.org/10.1016/j.scr.2016.12.018
Sorrells, S. F., Paredes, M. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J., Auguste, K. I., Chang, E. F., Gutierrez, A. J., Kriegstein, A. R., Mathern, G. W., Oldham, M. C., Huang, E. J., Garcia-Verdugo, J. M., Yang, Z., & Alvarez-Buylla, A. (2018). Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature, 555(7696), 377-381. https://doi.org/10.1038/nature25975
Struys, E. A., Salomons, G. S., Achouri, Y., Van Schaftingen, E., Grosso, S., Craigen, W. J., Verhoeven, N. M., & Jakobs, C. (2005). Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria. American Journal of Human Genetics, 76(2), 358-360. https://doi.org/10.1086/427890
Sun, C., Fu, J., Qu, Z., Li, D., Si, P., Qiao, Q., Zhang, W., Xue, Y., Zhen, J., & Wang, W. (2019). Chronic mild hypoxia promotes hippocampal neurogenesis involving Notch1 signaling in epileptic rats. Brain Research, 1714, 88-98. https://doi.org/10.1016/j.brainres.2019.02.011
Sun, L., Han, R. L., Guo, F., Chen, H., Wang, W., Chen, Z. Y., Liu, W., Sun, X. D., & Gao, C. J. (2020). Antagonistic effects of IL-17 and Astragaloside IV on cortical neurogenesis and cognitive behavior after stroke in adult mice through Akt/GSK-3 beta pathway. Cell Death Discovery, 6(1), 74. https://doi.org/10.1038/s41420-020-00298-8
Tang, C., Wang, M., Wang, P., Wang, L., Wu, Q., & Guo, W. (2019). Neural stem cells behave as a functional niche for the maturation of newborn neurons through the secretion of PTN. Neuron, 101(1), 32-44 e36. https://doi.org/10.1016/j.neuron.2018.10.051
Tang, C. F., Wang, C. Y., Wang, J. H., Wang, Q. N., Li, S. J., Wang, H. O., Zhou, F., & Li, J. M. (2022). Short-chain fatty acids ameliorate depressive-like behaviors of high fructose-fed mice by rescuing hippocampal neurogenesis decline and blood-brain barrier damage. Nutrients, 14(9), 1882. https://doi.org/10.3390/nu14091882
Tobin, M. K., Musaraca, K., Disouky, A., Shetti, A., Bheri, A., Honer, W. G., Kim, N., Dawe, R. J., Bennett, D. A., Arfanakis, K., & Lazarov, O. (2019). Human hippocampal neurogenesis persists in aged adults and alzheimer's disease patients. Cell Stem Cell, 24(6), 974-982. https://doi.org/10.1016/j.stem.2019.05.003
Tu, M., Zhu, P. L., Hu, S. B., Wang, W., Su, Z. P., Guan, J. Q., Sun, C. R., & Zheng, W. M. (2017). Notch1 signaling activation contributes to adult hippocampal neurogenesis following traumatic brain injury. Medical Science Monitor, 23, 5480-5487. https://doi.org/10.12659/Msm.907160
Vaidya, V. A., Vadodaria, K. C., & Jha, S. (2007). Neurotransmitter regulation of adult neurogenesis: Putative therapeutic targets. CNS & Neurological Disorders Drug Targets, 6(5), 358-374. https://doi.org/10.2174/187152707783220910
Vilar, M., & Mira, H. (2016). Regulation of neurogenesis by Neurotrophins during adulthood: Expected and unexpected roles. Frontiers in Neuroscience, 10, 26. https://doi.org/10.3389/fnins.2016.00026
Wang, J., Cui, Y. X., Yu, Z. Y., Wang, W. J., Cheng, X., Ji, W. L., Guo, S. Y., Zhou, Q., Wu, N., Chen, Y., Chen, Y., Song, X. P., Jiang, H., Wang, Y. X., Lan, Y., Zhou, B., Mao, L. Q., Li, J., Yang, H. M., … Yang, X. (2019). Brain endothelial cells maintain lactate homeostasis and control adult hippocampal neurogenesis. Cell Stem Cell, 25(6), 754-767.e9. https://doi.org/10.1016/j.stem.2019.09.009
Wang, L., Chang, X. Y., She, L., Xu, D., Huang, W., & Poo, M. M. (2015). Autocrine action of BDNF on dendrite development of adult-born hippocampal neurons. Journal of Neuroscience, 35(22), 8384-8393. https://doi.org/10.1523/Jneurosci.4682-14.2015
Wang, W., Wang, M. D., Yang, M., Zeng, B., Qiu, W. Y., Ma, Q., Jing, X. X., Zhang, Q. Q., Wang, B. S., Yin, C. H., Zhang, J. Y., Ge, Y. X., Lu, Y. F., Ji, W. Z., Wu, Q., Ma, C., & Wang, X. Q. (2022). Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans. Cell Research, 32(8), 729-743. https://doi.org/10.1038/s41422-022-00678-y
Wang, X. J., Sun, T., Kong, L., Shang, Z. H., Yang, K. Q., Zhang, Q. Y., Jing, F. M., Dong, L., Xu, X. F., Liu, J. X., Xin, H., & Chen, Z. Y. (2014). Gypenosides pre-treatment protects the brain against cerebral ischemia and increases neural stem cells/progenitors in the subventricular zone. International Journal of Developmental Neuroscience, 33, 49-56. https://doi.org/10.1016/j.ijdevneu.2013.12.001
Wu, J., Tian, W. J., Liu, Y., Wan, H. J., Zheng, J. L., Wang, X., Pan, H., Li, J., Luo, J. Y., Yang, X. R., Lau, L. F., Ghashghaei, H. T., & Shen, Q. (2020). Ependyma-expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular-subventricular zone. EMBO Journal, 39(5), e101679. https://doi.org/10.15252/embj.2019101679
Wyss-Coray, T. (2016). Ageing, neurodegeneration and brain rejuvenation. Nature, 539(7628), 180-186. https://doi.org/10.1038/nature20411
Xiong, Y., Mahmood, A., & Chopp, M. (2010). Angiogenesis, neurogenesis and brain recovery of function following injury. Current Opinion in Investigational Drugs, 11(3), 298-308.
Xu, M., Guo, Y., Wang, M., Luo, X., Shen, X., Li, Z., Wang, L., & Guo, W. (2023). L-arginine homeostasis governs adult neural stem cell activation by modulating energy metabolism in vivo. The EMBO Journal, 42(6), e112647. https://doi.org/10.15252/embj.2022112647
Xu, X. B., & Zeng, L. (1998). Degaussing of cylinders magnetized in Earth's magnetic field-a two-dimensional model of degaussing of submarine. Journal of Electromagnetic Waves and Applications, 12(8), 1039-1051. https://doi.org/10.1163/156939398x01277
Xu, X. F., Li, T., Wang, D. D., Chen, B., Wang, Y., & Chen, Z. Y. (2015). Integrin-linked kinase is essential for environmental enrichment enhanced hippocampal neurogenesis and memory. Scientific Reports, 5, 11456. https://doi.org/10.1038/srep11456
Xu, X. F., Wang, Y. C., Zong, L., Chen, Z. Y., & Li, Y. (2018). Elevating integrin-linked kinase expression has rescued hippocampal neurogenesis and memory deficits in an AD animal model. Brain Research, 1695, 65-77. https://doi.org/10.1016/j.brainres.2018.05.024
Yan, X. B., Hou, H. L., Wu, L. M., Liu, J., & Zhou, J. N. (2007). Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia. Neuropharmacology, 53(4), 487-495. https://doi.org/10.1016/j.neuropharm.2007.06.020
Yang, J., Zhu, H. W., Zhang, T. L., & Ding, J. P. (2021). Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations. Cell Discovery, 7(1), 3. https://doi.org/10.1038/s41421-020-00227-0
Yang, J. L., Hou, C. L., Ma, N., Liu, J., Zhang, Y., Zhou, J. S., Xu, L., & Li, L. J. (2007). Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress. Neurobiology of Learning and Memory, 87(2), 257-263. https://doi.org/10.1016/j.nlm.2006.09.001
Yang, N., Liu, X. Q., Niu, X. J., Wang, X. Q., Jiang, R., Yuan, N., Wang, J. R., Zhang, C. W., Lim, K. L., & Lu, L. (2022). Activation of autophagy ameliorates age-related neurogenesis decline and Neurodysfunction in adult mice. Stem Cell Reviews and Reports, 18(2), 626-641. https://doi.org/10.1007/s12015-021-10265-0
Yao, B., Christian, K. M., He, C., Jin, P., Ming, G. L., & Song, H. J. (2016). Epigenetic mechanisms in neurogenesis. Nature Reviews Neuroscience, 17(9), 537-549. https://doi.org/10.1038/nrn.2016.70
Yau, S. Y., Lau, B. W. M., Tong, J. B., Wong, R., Ching, Y. P., Qiu, G., Tang, S. W., Lee, T. M. C., & So, K. F. (2011). Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats. PLoS ONE, 6(9), e24263. https://doi.org/10.1371/journal.pone.0024263
Yau, S. Y., Li, A., Hoo, R. L. C., Ching, Y. P., Christie, B. R., Lee, T. M. C., Xu, A. M., & So, K. F. (2014). Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proceedings of the National Academy of Sciences of the United States of America, 111(44), 15810-15815. https://doi.org/10.1073/pnas.1415219111
Yu, T. S., Washington, P. M., & Kernie, S. G. (2016). Injury-induced neurogenesis: Mechanisms and relevance. The Neuroscientist, 22(1), 61-71. https://doi.org/10.1177/1073858414563616
Zhang, B., Wang, L., Zhan, A., Wang, M., Tian, L., Guo, W., & Pan, Y. (2021). Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition. Nature Communications, 12(1), 1174. https://doi.org/10.1038/s41467-021-21468-x
Zhang, J., Ji, F., Liu, Y. L., Lei, X. P., Li, H., Ji, G. J., Yuan, Z. Q., & Jiao, J. W. (2014). Ezh2 regulates adult hippocampal neurogenesis and memory. Journal of Neuroscience, 34(15), 5184-5199. https://doi.org/10.1523/Jneurosci.4129-13.2014
Zhang, J. Q., Rong, P. J., Zhang, L. J., He, H., Zhou, T., Fan, Y. H., Mo, L., Zhao, Q. Y., Han, Y., Li, S. Y., Wang, Y. F., Yan, W., Chen, H. F., & You, Z. L. (2021). IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis. Science Advances, 7(12), eabb9888. https://doi.org/10.1126/sciadv.abb9888
Zhang, R. R., Cui, Q. Y., Murai, K., Lim, Y. C., Smith, Z. D., Jin, S., Ye, P., Rosa, L., Lee, Y. K., Wu, H. P., Liu, W., Xu, Z. M., Yang, L., Ding, Y. Q., Tang, F., Meissner, A., Ding, C., Shi, Y., & Xu, G. L. (2013). Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell, 13(2), 237-245. https://doi.org/10.1016/j.stem.2013.05.006
Zhang, X., Chu, X. X., Chen, L., Fu, J., Wang, S., Song, J. J., Kan, G. H., Jiang, W. Z., He, G., Chen, X. P., & Li, W. D. (2019). Simulated weightlessness procedure, head-down bed rest impairs adult neurogenesis in the hippocampus of rhesus macaque. Molecular Brain, 12, 46. https://doi.org/10.1186/s13041-019-0459-y
Zhang, X. Q., Liu, T. T., Zhou, Z. K., Mu, X. P., Song, C. G., Xiao, T., Zhao, M., & Zhao, C. S. (2015). Enriched environment altered aberrant hippocampal neurogenesis and improved Long-term consequences after temporal lobe epilepsy in adult rats. Journal of Molecular Neuroscience, 56(2), 409-421. https://doi.org/10.1007/s12031-015-0571-0
Zhang, X. Q., Mei, Y. F., He, Y., Wang, D. P., Wang, J., Wei, X. J., Yang, E. L., Zhou, D. M., Shen, H. W., Peng, G. P., Shu, Q., Li, X. K., Luo, B. Y., Zhou, Y. D., & Sun, B. G. (2021). Ablating adult neural stem cells improves synaptic and cognitive functions in Alzheimer models. Stem Cell Reports, 16(1), 89-105. https://doi.org/10.1016/j.stemcr.2020.12.003
Zhang, X. Q., Wei, X. J., Mei, Y. F., Wang, D. P., Wang, J., Zhang, Y. P., Li, X. K., Gu, Y., Peng, G. P., & Sun, B. G. (2021). Modulating adult neurogenesis affects synaptic plasticity and cognitive functions in mouse models of Alzheimer's disease. Stem Cell Reports, 16(12), 3005-3019. https://doi.org/10.1016/j.stemcr.2021.11.003
Zheng, J., Li, H. L., Tian, N., Liu, F., Wang, L., Yin, Y. L., Yue, L. P., Ma, L. Y., Wan, Y., & Wang, J. Z. (2020). Interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing GABAergic transmission. Cell Stem Cell, 26(3), 331. https://doi.org/10.1016/j.stem.2019.12.015
Zheng, J. Y., Liang, K. S., Wang, X. J., Zhou, X. Y., Sun, J., & Zhou, S. N. (2017). Chronic estradiol administration during the early stage of Alzheimer's disease pathology rescues adult hippocampal neurogenesis and ameliorates cognitive deficits in a beta(1-42) mice. Molecular Neurobiology, 54(10), 7656-7669. https://doi.org/10.1007/s12035-016-0181-z
Zhou, J., Wang, X., Wang, M., Chang, Y., Zhang, F., Ban, Z., Tang, R., Gan, Q., Wu, S., Guo, Y., Zhang, Q., Wang, F., Zhao, L., Jing, Y., Qian, W., Wang, G., Guo, W., & Yang, C. (2019). The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. The Journal of Cell Biology, 218(2), 580-597. https://doi.org/10.1083/jcb.201807204
Zhou, Z. K., Liu, T. T., Sun, X. Y., Mu, X. P., Zhu, G., Xiao, T., Zhao, M., & Zhao, C. S. (2017). CXCR4 antagonist AMD3100 reverses the neurogenesis promoted by enriched environment and suppresses long-term seizure activity in adult rats of temporal lobe epilepsy. Behavioural Brain Research, 322, 83-91. https://doi.org/10.1016/j.bbr.2017.01.014
Zhu, H. F., Shao, Y. L., Qin, L., Wang, J. H., Feng, S., Jiang, Y. B., & Wan, D. (2019). Catalpol enhances neurogenesis and inhibits apoptosis of new neurons via BDNF, but not the BDNF/Trkb pathway. Drug Design Development and Therapy, 13, 4145-4156. https://doi.org/10.2147/Dddt.S223322
Zhu, L., Chi, T. Y., Zhao, X. M., Yang, L., Song, S. J., Lu, Q. H., Ji, X. F., Liu, P., Wang, L. H., & Zou, L. B. (2018). Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice. Journal of Physiological Sciences, 68(5), 555-565. https://doi.org/10.1007/s12576-017-0561-9