The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells.
autophagy
brain tumor
iron metabolism
mitophagy
non-apoptotic cell death
Journal
American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225
Informations de publication
Date de publication:
01 12 2023
01 12 2023
Historique:
medline:
30
11
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
ppublish
Résumé
Induction of alternative, non-apoptotic cell death programs such as cell-lethal autophagy and mitophagy represent possible strategies to combat glioblastoma (GBM). Here we report that VLX600, a novel iron chelator and oxidative phosphorylation (OXPHOS) inhibitor, induces a caspase-independent type of cell death that is partially rescued in adherent U251
Identifiants
pubmed: 37899749
doi: 10.1152/ajpcell.00293.2023
doi:
Substances chimiques
VLX600
0
Antineoplastic Agents
0
Mitochondrial Proteins
0
Iron Chelating Agents
0
Iron
E1UOL152H7
Proto-Oncogene Proteins c-bcl-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
C1451-C1469Subventions
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : 259130777