The Impact of the Association Between Nonalcoholic Fatty Liver Disease and Intrahepatic Cholestasis of Pregnancy on Maternal and Fetal Outcomes.
fatty liver
intrahepatic cholestasis of pregnancy
nonalcoholic fatty liver disease
outcomes
pregnancy
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
accepted:
26
09
2023
medline:
30
10
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
epublish
Résumé
Backgroundː Intrahepatic cholestasis of pregnancy (ICP), a hepatic condition that causes severe itching in late pregnancy, is linked to nonalcoholic fatty liver disease (NAFLD) due to disrupted bile acid balance. It poses maternal risks such as preterm labor and gestational diabetes and fetal risks such as preterm birth and respiratory distress. The study examined NAFLD's impact on ICP in pregnant women, highlighting management and research implications. Methodsː This retrospective study examined pregnant women (≥18 years) with ICP, assessing fatty liver with follow-up ultrasounds. Participants were divided into ICP only and ICP with fatty liver (FL) groups, excluding heavy alcohol users and incomplete data. Maternal age, medical history, and comorbidities were evaluated alongside abdominal ultrasounds to identify FL. Resultsː In this study of 43 pregnant women, the mean maternal age was 27 years. Patients with ICP and FL had significantly higher bile acid levels than those with ICP alone. However, no significant differences were found between the two groups regarding the history of gestational diabetes mellitus (GDM), dyslipidemia, polycystic ovarian syndrome (PCOS), parity, and hypothyroidism. Among women with ICP and FL, 51.85% underwent lower segment cesarean section (LSCS), while 43.75% with ICP without FL underwent LSCS. Conclusionsː ICP with FL did not show significant adverse effects on maternal and neonatal outcomes, including mode of delivery, gestational age, maternal complications, neonatal intensive care unit (NICU) admissions, and low birth weight (LBW) with asphyxia. However, additional research is required to fully comprehend the relationship between ICP, NAFLD, and their impact on pregnancy outcomes.
Identifiants
pubmed: 37900523
doi: 10.7759/cureus.46035
pmc: PMC10603217
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e46035Informations de copyright
Copyright © 2023, Koushik et al.
Déclaration de conflit d'intérêts
The authors have declared financial relationships, which are detailed in the next section.
Références
J Clin Exp Hepatol. 2022 May-Jun;12(3):818-829
pubmed: 35677499
J Clin Gastroenterol. 2017 Mar;51(3):240-246
pubmed: 27136960
Semin Liver Dis. 1993 Aug;13(3):289-301
pubmed: 8235718
BJOG. 2002 Mar;109(3):282-8
pubmed: 11950183
Med Clin North Am. 1996 Sep;80(5):1167-87
pubmed: 8804379
J Hepatol. 2020 Sep;73(3):516-522
pubmed: 32531415
Clin Liver Dis. 2004 Feb;8(1):167-76
pubmed: 15062199
BMJ Open Gastroenterol. 2022 Feb;9(1):
pubmed: 35193889
JGH Open. 2019 Jan 16;3(2):133-139
pubmed: 31061888
Environ Pollut. 2023 Apr 15;323:121348
pubmed: 36842621
World J Gastroenterol. 2014 Jul 28;20(28):9418-26
pubmed: 25071336
World J Gastroenterol. 2013 Oct 28;19(40):6714-20
pubmed: 24187446
Hepatology. 1982 Jan-Feb;2(1):87-96
pubmed: 7054071
Arch Womens Ment Health. 2012 Aug;15(4):297-305
pubmed: 22695807
J Obstet Gynaecol India. 2016 Oct;66(Suppl 1):38-41
pubmed: 27651575
Med Sci Monit. 2018 Jun 15;24:4080-4090
pubmed: 29905165
Hepatology. 2018 Jan;67(1):328-357
pubmed: 28714183
Gut. 1981 Jul;22(7):592-614
pubmed: 7021334
Gen Hosp Psychiatry. 2013 Jul-Aug;35(4):354-8
pubmed: 23541804
Clin Gastroenterol Hepatol. 2023 Apr 7;:
pubmed: 37031718