Oncogenic Osteomalacia: Challenges in Diagnosis.
FDG PET CT
Octreotide scan
Oncogenic osteomalacia
Phosphaturic mesenchymal tumour
Tumour-induced osteomalacia
Journal
Indian journal of surgical oncology
ISSN: 0975-7651
Titre abrégé: Indian J Surg Oncol
Pays: India
ID NLM: 101532448
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
16
03
2021
accepted:
04
11
2021
pmc-release:
01
09
2024
medline:
30
10
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
ppublish
Résumé
To report a case of osteomalacia induced by a mesenchymal tumour in the head and neck region, in view of its rarity and classical late diagnosis. To review the literature on the usage of fluorodeoxyglucose-positron emission tomography-computed tomography (FDG PET-CT) and octreotide scanning in the localisation of the culprit tumour. An elderly male presented with a 7-year history of chronic muscle pain and weakness, to the extent of functional disability. FDG PET-CT was done which showed uptake in the region of the right anterior ethmoids. Endoscopic excision of the mass was done. However, the patient did not improve significantly. Subsequently, a DOTA-1-NaI3-octreotide (DOTANOC) scan was done which revealed a tumour in the region of the right medial rectus, excision of which was done. This time, the patient improved clinically and biochemically. The histopathology was phosphaturic mesenchymal tumour. A steady but definitive symptomatic improvement was noted in the postoperative period along with reversal of the deranged biochemical parameters, confirming the diagnosis of oncogenic osteomalacia. Octreotide-based PET-CT seems to be the most sensitive imaging modality in localising the tumours that cause oncogenic osteomalacia. However, FDG-based PET-CT still would be a good choice in centres where SSTR-based imaging facilities are not available.
Identifiants
pubmed: 37900640
doi: 10.1007/s13193-021-01474-7
pii: 1474
pmc: PMC10611642
doi:
Types de publication
Journal Article
Langues
eng
Pagination
583-588Informations de copyright
© Indian Association of Surgical Oncology 2021.
Références
Helv Paediatr Acta. 1959 Dec;14:554-65
pubmed: 14434619
World J Clin Cases. 2013 Apr 16;1(1):59-63
pubmed: 24303466
Singapore Med J. 2009 Feb;50(2):e55-7
pubmed: 19296011
J Laryngol Otol. 2009 Sep;123(9):1052-4
pubmed: 19250593
Hawaii Med J. 2011 Jul;70(7):139-43
pubmed: 21886301
BMC Musculoskelet Disord. 2017 Sep 21;18(1):403
pubmed: 28934935
Endocr J. 2017 Jul 28;64(7):675-683
pubmed: 28450684
N Engl J Med. 2003 Apr 24;348(17):1656-63
pubmed: 12711740
Bone. 2005 Mar;36(3):375-8
pubmed: 15777669
J Bone Miner Res. 2012 Sep;27(9):1967-75
pubmed: 22532501
Cancer. 1987 Apr 15;59(8):1442-54
pubmed: 3545439
J Bone Miner Res. 2003 Jul;18(7):1227-34
pubmed: 12854832
Clin Endocrinol (Oxf). 2016 Jan;84(1):134-40
pubmed: 25996566
Osteoporos Int. 2017 Jul;28(7):2187-2193
pubmed: 28341900
Am J Med Sci. 2006 Sep;332(3):142-7
pubmed: 16969146
Int J Oral Maxillofac Surg. 2018 Oct;47(10):1295-1298
pubmed: 29571670
Curr Oncol. 2009 Sep;16(5):87-90
pubmed: 19862367
Endocr Relat Cancer. 2011 Jun 08;18(3):R53-77
pubmed: 21490240