The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice.
head twitch
lisuride
mice
prepulse inhibition
serotonin 2A receptor
serotonin-syndrome
β-arrestin
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
06
2023
accepted:
19
09
2023
medline:
30
10
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
epublish
Résumé
There is now evidence from multiple Phase II clinical trials that psychedelic drugs can exert long-lasting anxiolytic, anti-depressant, and anti-drug abuse (nicotine and ethanol) effects in patients. Despite these benefits, the hallucinogenic actions of these drugs at the serotonin 2A receptor (5-HT2AR) limit their clinical use in diverse settings. Activation of the 5-HT2AR can stimulate both G protein and
Identifiants
pubmed: 37900918
doi: 10.3389/fmolb.2023.1233743
pii: 1233743
pmc: PMC10603247
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1233743Subventions
Organisme : NIDA NIH HHS
ID : R37 DA045657
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2023 Pogorelov, Rodriguiz, Roth and Wetsel.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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