Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency.
Anakinra
anti- interleukin-1
mevalonate kinase deficiency
pediatrics
Journal
Global pediatric health
ISSN: 2333-794X
Titre abrégé: Glob Pediatr Health
Pays: United States
ID NLM: 101670224
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
08
2023
revised:
16
09
2023
accepted:
23
09
2023
medline:
30
10
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
epublish
Résumé
Mevalonate kinase deficiency (MKD) is a rare hereditary autoinflammatory disease, with a widely variable clinical spectrum. It is characterized by febrile recurrent episodes and systemic inflammation. Data on therapeutic options for MKD are still limited and remain unknown in our country. We report Moroccan cases with MKD referred in our unit and treated with Anakinra, an interleukin-1 receptor antagonist. Through this study, we evaluate the efficacy of this bioagent, in our 2 MKD patients, in whom Anakinra has shown a complete clinical remission, with a remaining mild inflammation for one case, and normalization of growth with rare episodes of cervical adenopathies for the second case. Our experience provides an additional argument supporting the efficacy of Anakinra treatment, demonstrated previously but still lacks of objective data.
Identifiants
pubmed: 37901181
doi: 10.1177/2333794X231207351
pii: 10.1177_2333794X231207351
pmc: PMC10605664
doi:
Types de publication
Case Reports
Langues
eng
Pagination
2333794X231207351Informations de copyright
© The Author(s) 2023.
Déclaration de conflit d'intérêts
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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