Removable Transduodenal Bypass: Development of a New Endoscopic Concept.
Diabetes
Endoscopic duodenal-jejunal bypass
Gastrointestinal liner
Metabolic endoscopy
Obesity
Reversible bypass
Journal
Visceral medicine
ISSN: 2297-4725
Titre abrégé: Visc Med
Pays: Switzerland
ID NLM: 101681546
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
29
03
2023
accepted:
15
06
2023
pmc-release:
01
08
2024
medline:
30
10
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
ppublish
Résumé
Obesity and obesity-related disease such as diabetes mellitus type 2 are a permanently rising concern worldwide. Current effective therapeutic options mostly include medication and surgery, but there is a lack of effective treatment options between medication and surgery. Previously, devices such as EndoBarrier A new removable transduodenal bypass was developed and tested on a porcine model. In this course, the device evolved in its mechanism and handling. The device is designed to avoid typical complications seen in previous duodenal liners. After further development of the device, implantation and use were feasible and safe in the porcine model. Autopsies showed that the device stayed in place and remained intact. The new removable transduodenal bypass aims to be a removable therapeutic option for diabetes mellitus type 2 and obesity, replacing previous duodenal lining devices. Use and handling of the device, however, are yet to be tested in the human model in the future.
Identifiants
pubmed: 37901387
doi: 10.1159/000531682
pii: 531682
pmc: PMC10601520
doi:
Types de publication
Journal Article
Langues
eng
Pagination
87-92Informations de copyright
© 2023 S. Karger AG, Basel.
Déclaration de conflit d'intérêts
Georg Kähler is the founder and shareholder of Trans-Duodenal Concepts GmbH. The other authors have no relevant financial or nonfinancial interests to disclose.
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