Immunohistochemical localization of CD31, CD34, and periostin in vocal fold polyps.
CD31
CD34
Vocal fold polyp
periostin
Journal
Acta oto-laryngologica
ISSN: 1651-2251
Titre abrégé: Acta Otolaryngol
Pays: England
ID NLM: 0370354
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
medline:
9
11
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
ppublish
Résumé
Long-term voice-abuse or sudden vocal fold microvascular disruption can lead to injury and subsequent repair/remodeling of the vocal fold mucosa. Periostin is known to be involved in airway remodeling and in various otolaryngological diseases. In ischemic heart disease, increased CD31 expression has been observed around cardiomyocytes during remodeling, and endothelial proliferation has been reported to occur at these sites. We investigated the expression and the roles of CD31, CD34, and periostin in the formation of vocal fold polyps. Fifty-seven samples of vocal fold polyps were investigate histopathologically and immunohistochemically. Expression of CD31 and CD34 was detected in 41 (71.9%) and 53 (93.0%) samples, respectively, obtained from patients with vocal fold polyp. Expression of periostin was detected in 41 (71.9%) samples obtained from patients with vocal polyps. The vocal polyp samples could be classified into three histological subtypes. Three patterns of CD31 and CD34 expression were observed in the vocal polyp. Four patterns of periostin expression were observed in vocal polyps. An association was observed between the CD31 expression pattern and the histological subtype of vocal fold polyps. In vocal fold polyps, evaluation of vascular endothelial markers may be useful for staging.
Sections du résumé
BACKGROUND
UNASSIGNED
Long-term voice-abuse or sudden vocal fold microvascular disruption can lead to injury and subsequent repair/remodeling of the vocal fold mucosa. Periostin is known to be involved in airway remodeling and in various otolaryngological diseases. In ischemic heart disease, increased CD31 expression has been observed around cardiomyocytes during remodeling, and endothelial proliferation has been reported to occur at these sites.
OBJECTIVES
UNASSIGNED
We investigated the expression and the roles of CD31, CD34, and periostin in the formation of vocal fold polyps.
MATERIALS AND METHODS
UNASSIGNED
Fifty-seven samples of vocal fold polyps were investigate histopathologically and immunohistochemically.
RESULT
UNASSIGNED
Expression of CD31 and CD34 was detected in 41 (71.9%) and 53 (93.0%) samples, respectively, obtained from patients with vocal fold polyp. Expression of periostin was detected in 41 (71.9%) samples obtained from patients with vocal polyps. The vocal polyp samples could be classified into three histological subtypes. Three patterns of CD31 and CD34 expression were observed in the vocal polyp. Four patterns of periostin expression were observed in vocal polyps. An association was observed between the CD31 expression pattern and the histological subtype of vocal fold polyps.
CONCLUSION AND SIGNIFICANCE
UNASSIGNED
In vocal fold polyps, evaluation of vascular endothelial markers may be useful for staging.
Identifiants
pubmed: 37902571
doi: 10.1080/00016489.2023.2263483
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM