The seroincidence of childhood Shigella sonnei infection in Ho Chi Minh City, Vietnam.
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
20
06
2023
accepted:
16
10
2023
revised:
09
11
2023
medline:
13
11
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
epublish
Résumé
Shigella sonnei is a pathogen of growing global importance as a cause of diarrhoeal illness in childhood, particularly in transitional low-middle income countries (LMICs). Here, we sought to determine the incidence of childhood exposure to S. sonnei infection in a contemporary transitional LMIC population, where it represents the dominant Shigella species. Participants were enrolled between the age of 12-36 months between June and December 2014. Baseline characteristics were obtained through standardized electronic questionnaires, and serum samples were collected at 6-month intervals over two years of follow-up. IgG antibody against S. sonnei O-antigen (anti-O) was measured using an enzyme-linked immunosorbent assay (ELISA). A four-fold increase in ELISA units (EU) with convalescent IgG titre >10.3 EU was taken as evidence of seroconversion between timepoints. A total of 3,498 serum samples were collected from 748 participants; 3,170 from the 634 participants that completed follow-up. Measures of anti-O IgG varied significantly by calendar month (p = 0.03). Estimated S. sonnei seroincidence was 21,451 infections per 100,000 population per year (95% CI 19,307-23,834), with peak incidence occurring at 12-18 months of age. Three baseline factors were independently associated with the likelihood of seroconversion; ever having breastfed (aOR 2.54, CI 1.22-5.26), history of prior hospital admission (aOR 0.57, CI 0.34-0.95), and use of a toilet spray-wash in the household (aOR 0.42, CI 0.20-0.89). Incidence of S. sonnei exposure in Ho Chi Minh City is substantial, with significant reduction in the likelihood of exposure as age increases beyond 2 years.
Sections du résumé
BACKGROUND
BACKGROUND
Shigella sonnei is a pathogen of growing global importance as a cause of diarrhoeal illness in childhood, particularly in transitional low-middle income countries (LMICs). Here, we sought to determine the incidence of childhood exposure to S. sonnei infection in a contemporary transitional LMIC population, where it represents the dominant Shigella species.
METHODS
METHODS
Participants were enrolled between the age of 12-36 months between June and December 2014. Baseline characteristics were obtained through standardized electronic questionnaires, and serum samples were collected at 6-month intervals over two years of follow-up. IgG antibody against S. sonnei O-antigen (anti-O) was measured using an enzyme-linked immunosorbent assay (ELISA). A four-fold increase in ELISA units (EU) with convalescent IgG titre >10.3 EU was taken as evidence of seroconversion between timepoints.
RESULTS
RESULTS
A total of 3,498 serum samples were collected from 748 participants; 3,170 from the 634 participants that completed follow-up. Measures of anti-O IgG varied significantly by calendar month (p = 0.03). Estimated S. sonnei seroincidence was 21,451 infections per 100,000 population per year (95% CI 19,307-23,834), with peak incidence occurring at 12-18 months of age. Three baseline factors were independently associated with the likelihood of seroconversion; ever having breastfed (aOR 2.54, CI 1.22-5.26), history of prior hospital admission (aOR 0.57, CI 0.34-0.95), and use of a toilet spray-wash in the household (aOR 0.42, CI 0.20-0.89).
CONCLUSIONS
CONCLUSIONS
Incidence of S. sonnei exposure in Ho Chi Minh City is substantial, with significant reduction in the likelihood of exposure as age increases beyond 2 years.
Identifiants
pubmed: 37903147
doi: 10.1371/journal.pntd.0011728
pii: PNTD-D-23-00760
pmc: PMC10635567
doi:
Substances chimiques
O Antigens
0
Immunoglobulin G
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0011728Informations de copyright
Copyright: © 2023 Jones et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Am J Trop Med Hyg. 2014 Apr;90(4):697-704
pubmed: 24591435
PLoS Pathog. 2015 Mar 20;11(3):e1004749
pubmed: 25794007
BMC Public Health. 2014 Dec 17;14:1289
pubmed: 25514820
Infect Immun. 2000 Oct;68(10):6056-61
pubmed: 10992522
Int J Environ Res Public Health. 2018 Oct 10;15(10):
pubmed: 30309010
Lancet. 2018 Feb 24;391(10122):801-812
pubmed: 29254859
PLoS Negl Trop Dis. 2015 Jun 11;9(6):e0003708
pubmed: 26068698
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17522-7
pubmed: 24082120
Vaccines (Basel). 2022 Aug 24;10(9):
pubmed: 36146457
PLoS One. 2012;7(6):e34651
pubmed: 22737206
Clin Infect Dis. 2018 Feb 1;66(4):504-511
pubmed: 29029149
J Infect Dis. 1997 May;175(5):1128-33
pubmed: 9129076
Hum Vaccin Immunother. 2019;15(6):1401-1408
pubmed: 31070988
BMJ Glob Health. 2022 Sep;7(9):
pubmed: 36660904
Nat Microbiol. 2020 Feb;5(2):256-264
pubmed: 31959970
Medicine (Baltimore). 2019 Aug;98(34):e16928
pubmed: 31441879
Vaccine. 2016 Feb 3;34(6):783-90
pubmed: 26742945
J Water Health. 2022 Jan;20(1):271-275
pubmed: 35100172
BMC Public Health. 2013 Oct 08;13:937
pubmed: 24103423
BMC Infect Dis. 2008 Sep 25;8:130
pubmed: 18816415
Am J Trop Med Hyg. 2015 May;92(5):1045-52
pubmed: 25802437
J Infect. 2007 Aug;55(2):194-200
pubmed: 17258812
Infect Dis Poverty. 2017 Jun 21;6(1):113
pubmed: 28637484
Sci Rep. 2013 Nov 21;3:3239
pubmed: 24257434
Nat Rev Microbiol. 2016 Apr;14(4):235-50
pubmed: 26923111
Environ Health Perspect. 2008 Jan;116(1):7-12
pubmed: 18197292
J Clin Microbiol. 1989 Jan;27(1):162-7
pubmed: 2463995
Front Immunol. 2017 May 29;8:584
pubmed: 28611768