A mechanosensitive caveolae-invadosome interplay drives matrix remodelling for cancer cell invasion.
Journal
Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
03
11
2022
accepted:
22
09
2023
pubmed:
31
10
2023
medline:
31
10
2023
entrez:
31
10
2023
Statut:
ppublish
Résumé
Invadosomes and caveolae are mechanosensitive structures that are implicated in metastasis. Here, we describe a unique juxtaposition of caveola clusters and matrix degradative invadosomes at contact sites between the plasma membrane of cancer cells and constricting fibrils both in 2D and 3D type I collagen matrix environments. Preferential association between caveolae and straight segments of the fibrils, and between invadosomes and bent segments of the fibrils, was observed along with matrix remodelling. Caveola recruitment precedes and is required for invadosome formation and activity. Reciprocally, invadosome disruption results in the accumulation of fibril-associated caveolae. Moreover, caveolae and the collagen receptor β1 integrin co-localize at contact sites with the fibrils, and integrins control caveola recruitment to fibrils. In turn, caveolae mediate the clearance of β1 integrin and collagen uptake in an invadosome-dependent and collagen-cleavage-dependent mechanism. Our data reveal a reciprocal interplay between caveolae and invadosomes that coordinates adhesion to and proteolytic remodelling of confining fibrils to support tumour cell dissemination.
Identifiants
pubmed: 37903910
doi: 10.1038/s41556-023-01272-z
pii: 10.1038/s41556-023-01272-z
pmc: PMC10709148
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1787-1803Subventions
Organisme : Institut National Du Cancer (French National Cancer Institute)
ID : INCa 2018-1-PL BIO-08-ICR-1
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-21-CE13-0018-01
Informations de copyright
© 2023. The Author(s).
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