Prefrontal circuits encode both general danger and specific threat representations.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
04
10
2022
accepted:
25
09
2023
medline:
4
12
2023
pubmed:
31
10
2023
entrez:
31
10
2023
Statut:
ppublish
Résumé
Behavioral adaptation to potential threats requires both a global representation of danger to prepare the organism to react in a timely manner but also the identification of specific threatening situations to select the appropriate behavioral responses. The prefrontal cortex is known to control threat-related behaviors, yet it is unknown whether it encodes global defensive states and/or the identity of specific threatening encounters. Using a new behavioral paradigm that exposes mice to different threatening situations, we show that the dorsomedial prefrontal cortex (dmPFC) encodes a general representation of danger while simultaneously encoding a specific neuronal representation of each threat. Importantly, the global representation of danger persisted in error trials that instead lacked specific threat identity representations. Consistently, optogenetic prefrontal inhibition impaired overall behavioral performance and discrimination of different threatening situations without any bias toward active or passive behaviors. Together, these data indicate that the prefrontal cortex encodes both a global representation of danger and specific representations of threat identity to control the selection of defensive behaviors.
Identifiants
pubmed: 37904042
doi: 10.1038/s41593-023-01472-8
pii: 10.1038/s41593-023-01472-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2147-2157Subventions
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-10-EQPX-08 OPTOPATH
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
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