PLGA nanoparticles engineering extracellular vesicles from human umbilical cord mesenchymal stem cells ameliorates polyethylene particles induced periprosthetic osteolysis.
Aseptic loosening
Exosomes
Human umbilical cord derived mesenchymal stem cells
PLGA
Periprosthetic osteolysis
Journal
Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208
Informations de publication
Date de publication:
31 Oct 2023
31 Oct 2023
Historique:
received:
10
05
2023
accepted:
26
10
2023
medline:
1
11
2023
pubmed:
31
10
2023
entrez:
31
10
2023
Statut:
epublish
Résumé
The wear particle-induced dissolution of bone around implants is a significant pathological factor in aseptic loosening, and controlling prosthetic aseptic loosening holds crucial social significance. While human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exos, Exos) have been found to effectively promote osteogenesis and angiogenesis, their role in periprosthetic osteolysis remains unexplored. To enhance their in vivo application, we engineered HucMSCs-Exos-encapsulated poly lactic-co-glycolic acid (PLGA) nanoparticles (PLGA-Exos). In our study, we demonstrate that PLGA-Exos stimulate osteogenic differentiation while inhibiting the generation of reactive oxygen species (ROS) and subsequent osteoclast differentiation in vitro. In vivo imaging revealed that PLGA-Exos released exosomes slowly and maintained a therapeutic concentration. Our in vivo experiments demonstrated that PLGA-Exos effectively suppressed osteolysis induced by polyethylene particles. These findings suggest that PLGA-Exos hold potential as a therapeutic approach for the prevention and treatment of periprosthetic osteolysis. Furthermore, they provide novel insights for the clinical management of osteolysis.
Identifiants
pubmed: 37904168
doi: 10.1186/s12951-023-02177-7
pii: 10.1186/s12951-023-02177-7
pmc: PMC10617042
doi:
Substances chimiques
Polyethylene
9002-88-4
Glycols
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
398Subventions
Organisme : the National Natural Science Foundation of China
ID : 81974339
Informations de copyright
© 2023. The Author(s).
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