Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology.


Journal

Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464

Informations de publication

Date de publication:
30 10 2023
Historique:
received: 24 06 2023
accepted: 27 09 2023
medline: 2 11 2023
pubmed: 31 10 2023
entrez: 31 10 2023
Statut: epublish

Résumé

tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, as well as involvement in cellular differentiation, proliferation, and apoptosis. tsRNA-related abnormalities have a significant influence on the onset, development, and progression of numerous human diseases, including malignant tumors through affecting the cell cycle and specific signaling molecules. This review introduced origins together with tsRNAs classification, providing a summary for regulatory mechanism and physiological function while dysfunctional effect of tsRNAs in digestive system diseases, focusing on the clinical prospects of tsRNAs for diagnostic and prognostic biomarkers. Video Abstract.

Identifiants

pubmed: 37904174
doi: 10.1186/s12964-023-01341-8
pii: 10.1186/s12964-023-01341-8
pmc: PMC10614346
doi:

Substances chimiques

RNA, Transfer 9014-25-9

Types de publication

Video-Audio Media Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

302

Informations de copyright

© 2023. The Author(s).

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Auteurs

Juan Du (J)

Health Science Center, Ningbo University, Ningbo, 315211, Zhejiang, China.

Tianyi Huang (T)

Health Science Center, Ningbo University, Ningbo, 315211, Zhejiang, China.

Zhen Zheng (Z)

Department of Radiation Oncology, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.

Shuai Fang (S)

The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang, China.

Hongxia Deng (H)

The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China. xixizb@163.com.

Kaitai Liu (K)

Department of Radiation Oncology, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China. lkt1982@126.com.

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