Preadipocytes in human granulation tissue: role in wound healing and response to macrophage polarization.
Adipose-derived stem cells
Granulation tissue
Inflammation
Macrophage polarization
Myofibroblasts
Preadipocytes
Tissue fibrosis
Wound healing
Journal
Inflammation and regeneration
ISSN: 1880-9693
Titre abrégé: Inflamm Regen
Pays: England
ID NLM: 101479577
Informations de publication
Date de publication:
31 Oct 2023
31 Oct 2023
Historique:
received:
05
10
2023
accepted:
15
10
2023
medline:
31
10
2023
pubmed:
31
10
2023
entrez:
31
10
2023
Statut:
epublish
Résumé
Chronic non-healing wounds pose a global health challenge. Under optimized conditions, skin wounds heal by the formation of scar tissue. However, deregulated cell activation leads to persistent inflammation and the formation of granulation tissue, a type of premature scar tissue without epithelialization. Regenerative cells from the wound periphery contribute to the healing process, but little is known about their cellular fate in an inflammatory, macrophage-dominated wound microenvironment. We examined CD45 CD45 Preadipocyte fate in wound tissue is influenced by macrophage polarization. Pro-inflammatory M1 macrophages induce a pro-fibrotic response in ASCs through IL1B and TGFB1 signaling, while anti-inflammatory M2 macrophages have limited effects. These findings shed light on cellular interactions in chronic wounds and provide important information for the potential therapeutic use of ASCs in human wound healing.
Sections du résumé
BACKGROUND
BACKGROUND
Chronic non-healing wounds pose a global health challenge. Under optimized conditions, skin wounds heal by the formation of scar tissue. However, deregulated cell activation leads to persistent inflammation and the formation of granulation tissue, a type of premature scar tissue without epithelialization. Regenerative cells from the wound periphery contribute to the healing process, but little is known about their cellular fate in an inflammatory, macrophage-dominated wound microenvironment.
METHODS
METHODS
We examined CD45
RESULTS
RESULTS
CD45
CONCLUSION
CONCLUSIONS
Preadipocyte fate in wound tissue is influenced by macrophage polarization. Pro-inflammatory M1 macrophages induce a pro-fibrotic response in ASCs through IL1B and TGFB1 signaling, while anti-inflammatory M2 macrophages have limited effects. These findings shed light on cellular interactions in chronic wounds and provide important information for the potential therapeutic use of ASCs in human wound healing.
Identifiants
pubmed: 37904253
doi: 10.1186/s41232-023-00302-5
pii: 10.1186/s41232-023-00302-5
pmc: PMC10617061
doi:
Types de publication
Journal Article
Langues
eng
Pagination
53Informations de copyright
© 2023. The Author(s).
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