Design of universal Ebola virus vaccine candidates


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
17 Oct 2023
Historique:
pubmed: 31 10 2023
medline: 31 10 2023
entrez: 31 10 2023
Statut: epublish

Résumé

Ebola virus causes hemorrhagic fever in humans and poses a significant threat to global public health. Although two viral vector vaccines have been approved to prevent Ebola virus disease, they are distributed in the limited ring vaccination setting and only indicated for prevention of infection from

Identifiants

pubmed: 37904982
doi: 10.1101/2023.10.14.562364
pmc: PMC10614775
pii:
doi:

Types de publication

Preprint

Langues

eng

Déclaration de conflit d'intérêts

COMPETING INTERESTS D.X., A.E.P. and P.S.K. are named as inventors on a patent application applied for by Stanford University and the Chan Zuckerberg Biohub on immunogenic ebolavirus fusion proteins and related methods. A.E.P. is an employee of, and P.S.K. is a co-founder and member of the Board of Directors of Vaccine Company, Inc. N.J.S. is a named inventor for filovirus vaccines. All other authors declare no competing interests.

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Auteurs

Duo Xu (D)

Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.

Abigail E Powell (AE)

Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.

Ashley Utz (A)

Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.
Stanford Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stanford Biophysics Program, Stanford University School of Medicine, Stanford, CA 94305, USA.

Mrinmoy Sanyal (M)

Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.

Jonathan Do (J)

Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.

J J Patten (JJ)

National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

Juan I Moliva (JI)

National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

Nancy J Sullivan (NJ)

National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.
Department of Biology, Boston University, Boston, MA 02118, USA.

Robert A Davey (RA)

National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

Peter S Kim (PS)

Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.
Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

Classifications MeSH