Let-7a-5p abrogates progression of papillary thyroid carcinoma cells by decreasing nuclear receptor subfamily 6 group a member 1-mediated lipogenesis.
NR6A1
let-7a-5p
lipogenesis
papillary thyroid carcinoma
tumor progression
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
31 Oct 2023
31 Oct 2023
Historique:
revised:
20
08
2023
received:
16
03
2023
accepted:
18
10
2023
medline:
31
10
2023
pubmed:
31
10
2023
entrez:
31
10
2023
Statut:
aheadofprint
Résumé
Increasing evidence shows that microRNAs (miRNAs) contribute vital roles in papillary thyroid carcinoma (PTC) carcinogenesis, proliferation, invasion, and so on. As the most common endocrine malignancy, there still have largely unknown molecular events. First, our analysis and open access database information indicates that the downregulation of let-7a-5p accelerates PTC progression. Next, lentivirus mediates the overexpression of let-7a-5p PTC cells, and found let-7a-5p suppressed cancer cells proliferation and invasion. Interestingly, bioinformatics analysis hints NR6A1 is the potential target gene of let-7a-5p. The regulation was validated by luciferase and quantitative reverse transcription polymerase chain reaction (qRT-PCR) in PTC tissue and the clinic tumors. Moreover, let-7a-5p regulated NR6A1 involved in PTC cells lipogensis in vitro and in vivo. Finally, let-7a-5p abrogates PCT xenograft tumors growth, NR6A1 expression and lipogenesis. Taken together, our data indicates that let-7a-5p suppresses PCT progression through decreased lipogenesis, the related let-7a-5p/NR6A1axis might be promising candidate targets for PTC treatment.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23572Subventions
Organisme : National Natural Science Foundation of China
ID : 31600269
Organisme : Clinical Medical Science and Technology Development Project of Jiangsu University
ID : JLY2021071
Organisme : Science and Technology Program of Sichuan Province
ID : 19YYJC1242
Organisme : The Innovation Project of Chengdu Medical College
ID : YCX2021-36
Organisme : Natural Science Foundation of Laboratory Medicine School in Chengdu Medical College
ID : JYZK202203
Organisme : Collaborative Fund of Chengdu Medical College - People's Hospital of Pidu District in Chengdu
ID : 2021LHZD-04
Organisme : Youth Health Excellent Talent Training Project of Jiangyin
ID : JYROYT202307
Informations de copyright
© 2023 Wiley Periodicals LLC.
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