Candidate gene-environment interactions in substance abuse: A systematic review.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2023
2023
Historique:
received:
28
07
2022
accepted:
06
06
2023
medline:
2
11
2023
pubmed:
31
10
2023
entrez:
31
10
2023
Statut:
epublish
Résumé
The abuse of psychogenic drugs can lead to multiple health-related problems. Genetic and environmental vulnerabilities are factors in the emergence of substance use disorders. Empirical evidence regarding the gene-environment interaction in substance use is mixed. Summaries of the latest findings from a candidate gene approach will be useful for revealing the significance of particular gene contributions. Thus, we aim to identify different gene-environment interactions in patterns of substance use and investigate whether any effects trend notably across different genders and races. We reviewed published studies, until March 1, 2022, on substance use for candidate gene-environment interaction. Basic demographics of the included studies, target genes, environmental factors, main findings, patterns of gene-environment interaction, and other relevant information were collected and summarized. Among a total of 44 studies, 38 demonstrated at least one significant interaction effect. About 61.5% of studies on the 5-HTTLPR gene, 100% on the MAOA gene, 42.9% on the DRD2 gene, 50% on the DRD4 gene, 50% on the DAT gene, 80% on the CRHR1 gene, 100% on the OPRM1 gene, 100% on the GABRA1 gene, and 50% on the CHRNA gene had a significant gene-environment interaction effect. The diathesis-stress model represents a dominant interaction pattern (89.5%) in the studies with a significant interaction effect; the remaining significant effect on substance use is found in the differential susceptibility model. The social push and swing model were not reported in the included studies. The gene-environment interaction research on substance use behavior is methodologically multidimensional, which causes difficulty in conducting pooled analysis, or stated differently-making it hard to identify single sources of significant influence over maladaptive patterns of drug taking. In decreasing the heterogeneity and facilitating future pooled analysis, researchers must (1) replicate the existing studies with consistent study designs and measures, (2) conduct power calculations to report gene-environment correlations, (3) control for covariates, and (4) generate theory-based hypotheses with factorial based experiments when designing future studies.
Sections du résumé
BACKGROUND
The abuse of psychogenic drugs can lead to multiple health-related problems. Genetic and environmental vulnerabilities are factors in the emergence of substance use disorders. Empirical evidence regarding the gene-environment interaction in substance use is mixed. Summaries of the latest findings from a candidate gene approach will be useful for revealing the significance of particular gene contributions. Thus, we aim to identify different gene-environment interactions in patterns of substance use and investigate whether any effects trend notably across different genders and races.
METHODS
We reviewed published studies, until March 1, 2022, on substance use for candidate gene-environment interaction. Basic demographics of the included studies, target genes, environmental factors, main findings, patterns of gene-environment interaction, and other relevant information were collected and summarized.
RESULTS
Among a total of 44 studies, 38 demonstrated at least one significant interaction effect. About 61.5% of studies on the 5-HTTLPR gene, 100% on the MAOA gene, 42.9% on the DRD2 gene, 50% on the DRD4 gene, 50% on the DAT gene, 80% on the CRHR1 gene, 100% on the OPRM1 gene, 100% on the GABRA1 gene, and 50% on the CHRNA gene had a significant gene-environment interaction effect. The diathesis-stress model represents a dominant interaction pattern (89.5%) in the studies with a significant interaction effect; the remaining significant effect on substance use is found in the differential susceptibility model. The social push and swing model were not reported in the included studies.
CONCLUSION
The gene-environment interaction research on substance use behavior is methodologically multidimensional, which causes difficulty in conducting pooled analysis, or stated differently-making it hard to identify single sources of significant influence over maladaptive patterns of drug taking. In decreasing the heterogeneity and facilitating future pooled analysis, researchers must (1) replicate the existing studies with consistent study designs and measures, (2) conduct power calculations to report gene-environment correlations, (3) control for covariates, and (4) generate theory-based hypotheses with factorial based experiments when designing future studies.
Identifiants
pubmed: 37906564
doi: 10.1371/journal.pone.0287446
pii: PONE-D-22-20718
pmc: PMC10617739
doi:
Types de publication
Systematic Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0287446Informations de copyright
Copyright: © 2023 Jiang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Genes Brain Behav. 2010 Aug;9(6):658-67
pubmed: 20528958
Alcohol Alcohol. 2005 Sep-Oct;40(5):453-60
pubmed: 15972275
Nat Genet. 2010 May;42(5):448-53
pubmed: 20418888
Public Health Rep. 1988 Nov-Dec;103(6):690-8
pubmed: 3141966
Nicotine Tob Res. 2017 Apr 01;19(4):387-400
pubmed: 27613915
Biol Psychiatry. 2007 Sep 15;62(6):588-92
pubmed: 17336939
CNS Neurosci Ther. 2019 Jan;25(1):101-111
pubmed: 29952131
Mol Psychiatry. 2002;7(2):224-8
pubmed: 11840318
Alcohol Clin Exp Res. 2020 Apr;44(4):983-991
pubmed: 32020635
Biol Psychiatry. 2007 Mar 1;61(5):609-16
pubmed: 16920076
Hum Genet. 1998 Sep;103(3):273-9
pubmed: 9799080
Alcohol Clin Exp Res. 2009 Dec;33(12):2103-12
pubmed: 19764934
Cereb Cortex. 2007 May;17(5):1007-19
pubmed: 16751296
J Cell Mol Med. 2018 Mar;22(3):1778-1791
pubmed: 29314569
Ann Intern Med. 2009 Aug 18;151(4):264-9, W64
pubmed: 19622511
Science. 1996 Nov 29;274(5292):1527-31
pubmed: 8929413
Biol Psychiatry. 2010 Jan 1;67(1):20-7
pubmed: 19833324
Behav Genet. 2019 Jul;49(4):349-365
pubmed: 31111357
Dev Psychopathol. 2015 Nov;27(4 Pt 2):1489-502
pubmed: 26535939
Psychiatr Genet. 2007 Feb;17(1):35-8
pubmed: 17167343
Alcohol Clin Exp Res. 2013 Feb;37(2):325-31
pubmed: 23136901
Am J Med Genet. 2000 Jun 12;96(3):302-6
pubmed: 10898904
Mol Psychiatry. 2006 Jun;11(6):594-602
pubmed: 16550213
Drug Alcohol Depend. 2008 Jan 11;93(1-2):51-62
pubmed: 18029114
BMJ Open. 2019 Sep 4;9(9):e030328
pubmed: 31488488
Addiction. 2007 Mar;102(3):389-98
pubmed: 17298646
J Stud Alcohol. 2006 Mar;67(2):185-94
pubmed: 16562401
Science. 2002 Aug 2;297(5582):851-4
pubmed: 12161658
Am J Hum Genet. 2004 Apr;74(4):705-14
pubmed: 15024690
Biol Psychiatry. 2008 May 1;63(9):852-7
pubmed: 17949693
Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):926-33
pubmed: 19132693
Neuropsychopharmacology. 2013 Aug;38(9):1737-47
pubmed: 23518607
Behav Genet. 2013 Sep;43(5):402-14
pubmed: 23974430
Neuropsychopharmacology. 2012 Feb;37(3):669-76
pubmed: 22012472
Nicotine Tob Res. 2004 Aug;6(4):583-97
pubmed: 15370155
Prog Neuropsychopharmacol Biol Psychiatry. 2015 Dec 3;63:30-4
pubmed: 26028496
Nat Neurosci. 2005 Jun;8(6):828-34
pubmed: 15880108
Mol Psychiatry. 2008 Apr;13(4):368-73
pubmed: 18227835
J Neurochem. 1995 Sep;65(3):1157-65
pubmed: 7643093
J Pain Res. 2013 May 01;6:331-53
pubmed: 23658496
Biomolecules. 2020 Dec 03;10(12):
pubmed: 33287325
Int J Neuropsychopharmacol. 2001 Mar;4(1):33-42
pubmed: 11343627
Science. 2003 Jul 18;301(5631):386-9
pubmed: 12869766
Nat Rev Neurosci. 2011 Oct 20;12(11):670-84
pubmed: 22011682
PLoS One. 2012;7(12):e50576
pubmed: 23227187
Biochem Med (Zagreb). 2021 Feb 15;31(1):010502
pubmed: 33380887
Neuropsychopharmacology. 2009 Feb;34(3):698-706
pubmed: 18704094
Biol Psychiatry. 2007 Jun 1;61(11):1228-34
pubmed: 17123474
Hum Mol Genet. 2007 Jan 1;16(1):36-49
pubmed: 17135278
Am J Psychiatry. 1999 Jun;156(6):837-41
pubmed: 10360120
Psychoneuroendocrinology. 2018 Jan;87:173-180
pubmed: 29100174
Front Genet. 2020 Jan 17;10:1314
pubmed: 32010186
Mol Psychiatry. 2007 Jan;12(1):47-54
pubmed: 16969368
Alcohol Clin Exp Res. 2005 Apr;29(4):564-70
pubmed: 15834221
Addict Biol. 2013 Jul;18(4):717-26
pubmed: 22126256
J Abnorm Child Psychol. 2002 Aug;30(4):311-26
pubmed: 12108763
Clin Child Fam Psychol Rev. 1999 Sep;2(3):149-68
pubmed: 11227072
Biol Psychiatry. 2009 Jul 15;66(2):102-9
pubmed: 19358979
Cogn Affect Behav Neurosci. 2006 Mar;6(1):44-52
pubmed: 16869228
Alcohol Clin Exp Res. 2018 Mar;42(3):508-519
pubmed: 29222910
Dev Psychopathol. 2012 Feb;24(1):181-93
pubmed: 22293003
Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):533-40
pubmed: 17427187
Neuropsychopharmacology. 2004 Aug;29(8):1498-505
pubmed: 15150530
Mol Psychiatry. 2013 Apr;18(4):512-20
pubmed: 22488255
Mov Disord. 2000 Nov;15(6):1070-4
pubmed: 11104188
Cent Eur J Public Health. 2011 Mar;19(1):41, 45
pubmed: 21526655
Alcohol Clin Exp Res. 2014 Mar;38(3):704-12
pubmed: 24134200
Biol Psychiatry. 2011 Apr 1;69(7):650-60
pubmed: 21168125
Behav Brain Funct. 2007 Jan 10;3:2
pubmed: 17214892
Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 5;144B(2):159-64
pubmed: 17034017
Mol Psychiatry. 2009 Oct;14(10):912-45
pubmed: 19564872
Alcohol Clin Exp Res. 2007 Jan;31(1):1-10
pubmed: 17207095
Arch Gen Psychiatry. 1991 Jul;48(7):648-54
pubmed: 2069496
Hum Mol Genet. 2007 Jan 1;16(1):24-35
pubmed: 17158188
Science. 2008 Nov 7;322(5903):842-5
pubmed: 18988819
Nature. 2005 Jan 6;433(7021):68-72
pubmed: 15635411
Psychiatr Genet. 2006 Feb;16(1):9-17
pubmed: 16395124
Alcohol. 1998 Jul;16(1):33-45
pubmed: 9650634
Addict Behav. 2015 Mar;42:180-4
pubmed: 25481451
PLoS One. 2014 Jan 21;9(1):e86497
pubmed: 24466121
Cell. 2015 Aug 13;162(4):712-25
pubmed: 26276628
Mol Psychiatry. 2004 Oct;9(10):896-7
pubmed: 15197398
Dev Psychopathol. 2019 May;31(2):457-469
pubmed: 29895335
Addiction. 2009 Oct;104(10):1731-1740
pubmed: 20871796
Alcohol Clin Exp Res. 2004 Dec;28(12):1789-95
pubmed: 15608594
Alcohol. 2001 Feb;23(2):117-22
pubmed: 11331109
Int J Biol Sci. 2007 Oct 25;3(7):420-7
pubmed: 17998950
Mol Psychiatry. 2006 Aug;11(8):771-81
pubmed: 16770336
Am J Med Genet. 2001 Jan 8;105(1):114-9
pubmed: 11424981
Addict Biol. 2010 Jan;15(1):1-11
pubmed: 19878140
Behav Genet. 2006 Sep;36(5):640-50
pubmed: 16622805
Biol Psychiatry. 2008 Jan 15;63(2):146-51
pubmed: 17597588
Clin Child Fam Psychol Rev. 2015 Dec;18(4):413-42
pubmed: 26537239
Br J Psychiatry. 2012 Feb;200(2):116-23
pubmed: 22297589
Dev Psychopathol. 2016 May;28(2):415-31
pubmed: 26073189
Nat Genet. 2005 Feb;37(2):129-37
pubmed: 15654335
Nature. 2008 Apr 3;452(7187):638-642
pubmed: 18385739
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jun 8;108:110167
pubmed: 33166669
Neuropsychopharmacology. 2000 Feb;22(2):133-9
pubmed: 10649826
Mol Psychiatry. 2008 Mar;13(3):334-47
pubmed: 17592478
Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12224-9
pubmed: 16093315
Psychol Med. 2004 Oct;34(7):1251-61
pubmed: 15697051
Addict Biol. 2008 Sep;13(3-4):440-8
pubmed: 18782386
Hum Genet. 2014 Mar;133(3):357-65
pubmed: 24178752
J Health Soc Behav. 2013 Mar;54(1):92-108
pubmed: 23292504
Am J Med Genet. 1995 Apr 24;60(2):122-6
pubmed: 7485245
Psychol Bull. 2009 Nov;135(6):885-908
pubmed: 19883141
Mol Psychiatry. 2010 Jul;15(7):727-35
pubmed: 19238152
Addict Behav. 2018 Sep;84:231-237
pubmed: 29751336
Nat Genet. 2010 May;42(5):436-40
pubmed: 20418889
Genes Brain Behav. 2013 Jun;12(4):361-9
pubmed: 23473364
Genome Med. 2010 Apr 27;2(4):26
pubmed: 20423533
Neuropsychopharmacology. 2014 Mar;39(4):907-18
pubmed: 24136292
Hum Brain Mapp. 2017 Sep;38(9):4574-4593
pubmed: 28603901
Mol Psychiatry. 2012 May;17(5):511-9
pubmed: 21483437
Nature. 1997 Apr 24;386(6627):830-3
pubmed: 9126741
Alcohol Clin Exp Res. 2007 Mar;31(3):395-403
pubmed: 17295723
World J Biol Psychiatry. 2019 Oct;20(8):605-615
pubmed: 28854834
J Psychiatr Res. 2015 Sep;68:83-90
pubmed: 26228405
Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(8):960-8
pubmed: 21998007
Nature. 2005 Mar 17;434(7031):400-4
pubmed: 15772666
Nat Rev Genet. 2019 Aug;20(8):467-484
pubmed: 31068683
Int J Neuropsychopharmacol. 2010 Jul;13(6):703-14
pubmed: 19607758
Psychiatr Genet. 2007 Dec;17(6):323-32
pubmed: 18075472
Hum Mol Genet. 2006 Mar 15;15(6):807-19
pubmed: 16476706
AJS. 2015 Nov;121(3):914-54
pubmed: 26900620
Neuropsychopharmacology. 2007 Aug;32(8):1687-94
pubmed: 17251907