Protocol for implementing medial forebrain bundle stimulation as a reward for perceptual tasks in mice.
Behavior
Model Organisms
Neuroscience
Journal
STAR protocols
ISSN: 2666-1667
Titre abrégé: STAR Protoc
Pays: United States
ID NLM: 101769501
Informations de publication
Date de publication:
30 Oct 2023
30 Oct 2023
Historique:
received:
07
08
2023
revised:
24
09
2023
accepted:
05
10
2023
medline:
31
10
2023
pubmed:
31
10
2023
entrez:
31
10
2023
Statut:
aheadofprint
Résumé
Training mice to perform perceptual tasks is a vital part of integrative neuroscience. Replacing classical rewards like water with medial forebrain bundle (MFB) stimulation allows experimenters to avoid deprivation and obtain higher trial numbers per session. Here, we provide a protocol for implementing MFB-based reward in mice. We describe steps for MFB electrode implantation, efficacy testing, and stimulation calibration. After these steps, MFB reward can be used to facilitate sensory discrimination task training and enable nuanced characterization of psychophysical abilities. For complete details on the use and execution of this protocol, please refer to Verdier et al. (2022).
Identifiants
pubmed: 37906597
pii: S2666-1667(23)00636-6
doi: 10.1016/j.xpro.2023.102669
pmc: PMC10630816
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102669Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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