Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53.
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
31 10 2023
31 10 2023
Historique:
received:
09
12
2022
accepted:
19
10
2023
revised:
17
10
2023
medline:
2
11
2023
pubmed:
1
11
2023
entrez:
1
11
2023
Statut:
epublish
Résumé
Acute kidney injury (AKI) is a clinical syndrome with high morbidity and mortality but no specific therapy. Microsomal prostaglandin E synthase-2 (mPGES-2) is a PGE
Identifiants
pubmed: 37907523
doi: 10.1038/s41419-023-06236-7
pii: 10.1038/s41419-023-06236-7
pmc: PMC10618563
doi:
Substances chimiques
Cisplatin
Q20Q21Q62J
Heme
42VZT0U6YR
Prostaglandin-E Synthases
EC 5.3.99.3
Tumor Suppressor Protein p53
0
Ptges2 protein, mouse
EC 5.3.99.3
Trp53 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
710Informations de copyright
© 2023. The Author(s).
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