Puerarin alleviates inflammation and pathological damage in colitis mice by regulating metabolism and gut microbiota.
gut microbiota
network pharmacology
puerarin
ulcerative colitis
untargeted metabonomics
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
08
2023
accepted:
28
09
2023
medline:
1
11
2023
pubmed:
1
11
2023
entrez:
1
11
2023
Statut:
epublish
Résumé
Dysbiosis of gut microbiota and metabolic pathway disorders are closely related to the ulcerative colitis. Through network pharmacology, we found that puerarin is a potential ingredient that can improve the crypt deformation and inflammatory infiltration in mice, and decrease the levels of IL-1β, IL-6 and TNF-α significantly.
Identifiants
pubmed: 37908541
doi: 10.3389/fmicb.2023.1279029
pmc: PMC10614640
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1279029Informations de copyright
Copyright © 2023 Zou, Ding, Wu, Chen and Ruan.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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