Pulmonary Alveolar Proteinosis-associated Pulmonary Fibrosis: Evolutional Changes and Radiologic-Pathologic Correlation.
CT
Inflammation
Lung
Pathology
Journal
Radiology. Cardiothoracic imaging
ISSN: 2638-6135
Titre abrégé: Radiol Cardiothorac Imaging
Pays: United States
ID NLM: 101748663
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
13
02
2023
revised:
06
09
2023
accepted:
13
09
2023
medline:
1
11
2023
pubmed:
1
11
2023
entrez:
1
11
2023
Statut:
epublish
Résumé
Pulmonary alveolar proteinosis (PAP) is a rare disease with frequently favorable outcomes. In a minority of patients with primary or secondary PAP, the disease course may be complicated by pulmonary fibrosis (PF) despite appropriate management. Imaging and histopathologic manifestations of uncomplicated PAP are well-known. In contrast, radiologic-pathologic descriptions of PAP-associated PF (PAP-PF) are limited. The current manuscript presents three cases of PAP-PF, each with serial high-resolution CT imaging demonstrating the longitudinal progression of this unusual complication, with concordant pathologic findings in two patients. Much remains to be known regarding adverse prognostic factors contributing to PAP-PF. Early recognition of radiologic-pathologic manifestations would allow timely diagnosis and management optimization.
Identifiants
pubmed: 37908551
doi: 10.1148/ryct.230040
pmc: PMC10613927
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e230040Informations de copyright
© 2023 by the Radiological Society of North America, Inc.
Déclaration de conflit d'intérêts
Disclosures of conflicts of interest: E.H.W. No relevant relationships. L.C. No relevant relationships. L.L. No relevant relationships. H.L. No relevant relationships. A.N.H. No relevant relationships. M.E.S. Grants or contracts from Boehringer Ingelheim, the National Institutes of Health, and the Pulmonary Fibrosis Foundation, all paid to author’s institution; honoraria from CHEST for CME lectures and Self-education and Evaluation of Knowledge (SEEK) Pulmonary Board Review textbook; medical writing support provided by Fleishman Hillard; participation on adjudication committee for FibroGen. J.H.C. Senior consulting editor for Radiology: Cardiothoracic Imaging.
Références
Respir Med. 2011 Dec;105(12):1908-16
pubmed: 21900000
Eur Respir J. 2004 Apr;23(4):526-31
pubmed: 15083749
AJR Am J Roentgenol. 2018 Feb;210(2):307-313
pubmed: 29140119
N Engl J Med. 1958 Jun 5;258(23):1123-42
pubmed: 13552931
Radiographics. 2008 May-Jun;28(3):883-99; quiz 915
pubmed: 18480490
Am J Respir Crit Care Med. 2002 Jul 15;166(2):215-35
pubmed: 12119235
Eur Radiol. 2018 Feb;28(2):788-795
pubmed: 28812135
AJR Am J Roentgenol. 2016 Sep;207(3):544-51
pubmed: 27548000
Pneumonol Alergol Pol. 2014;82(3):206-17
pubmed: 24793148
J Thorac Dis. 2018 Oct;10(10):5774-5783
pubmed: 30505485
BMC Pulm Med. 2017 Nov 21;17(1):147
pubmed: 29162083
N Engl J Med. 2019 Sep 5;381(10):923-932
pubmed: 31483963
Radiographics. 2012 Jan-Feb;32(1):33-50
pubmed: 22236892
Ann Diagn Pathol. 2003 Apr;7(2):82-6
pubmed: 12715332
Orphanet J Rare Dis. 2018 Jul 31;13(1):129
pubmed: 30064481
AJR Am J Roentgenol. 2001 May;176(5):1287-94
pubmed: 11312196
Eur Respir Rev. 2011 Jun;20(120):98-107
pubmed: 21632797
J Thorac Imaging. 2005 Aug;20(3):242-4
pubmed: 16077345
Chest. 2009 Nov;136(5):1348-1355
pubmed: 19892674
AJR Am J Roentgenol. 2010 Oct;195(4):916-22
pubmed: 20858818
Toxicol Pathol. 2017 Apr;45(3):389-401
pubmed: 28136187
Am J Respir Crit Care Med. 2008 Apr 1;177(7):752-62
pubmed: 18202348