Emergent Risk Group-4 (RG-4) Filoviruses: A paradox in progress.
Biosafety Laboratory (BSL)-4
Bombali
Bundibugyo
CDC
ChatGPT
Cueva
Ebola
Filoviridae
Marburg
NIAID
NIH
Ravn
Reston
Sudan
Tai forest (formerly Côte d'Ivoire)
Thamno
Wolfram Mathematica
World Health Organization (WHO) Risk Group 4 (RG-4) virus pathogens
Zaire
and Stria viruses
bats
biodefense
ecology
emergent virus
global warming
health-care setting
humans
monkeys
paradox
reservoir
rodents
sexual risk
vector
virulence
Journal
Bioinformation
ISSN: 0973-2063
Titre abrégé: Bioinformation
Pays: Singapore
ID NLM: 101258255
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
08
2023
revised:
31
08
2023
accepted:
31
08
2023
medline:
1
11
2023
pubmed:
1
11
2023
entrez:
1
11
2023
Statut:
epublish
Résumé
Filoviruses, categorized as World Health Organization (WHO) Risk Group 4 (RG-4) pathogens, represent significant global health risks due to their extraordinary virulence. The Filoviridae family encompasses Ebola strains such as Sudan, Zaire, Bundibugyo, Tai Forest (formerly known as Ivory Coast), Reston, and Bombali, in addition to the closely related Marburg and Ravn virus strains. Filoviruses originated from a common ancestor about 10,000 years ago and displayed remarkable consistency in genetic heterogeneity until the 20th century. However, they overcame a genetic bottleneck by mid-century. Paradoxically, this resulted in the emergence of boosted virulent strains from the 1970's onward. Filovirus research is included in the NIAID Biodefense Program and utilizes the highest level specialized protective laboratories, Biosafety Laboratory (BSL)-4. The spread of Filoviruses as well as other RG-4 pathogens within Africa poses a significant health threat increasingly both in Africa and out of Africa.
Identifiants
pubmed: 37908613
doi: 10.6026/97320630019829
pii: 97320630019829
pmc: PMC10613816
doi:
Types de publication
Editorial
Langues
eng
Pagination
829-832Informations de copyright
© 2023 Biomedical Informatics.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.
Références
Mol Biol Evol. 1997 Aug;14(8):800-6
pubmed: 9254917
Emerg Infect Dis. 2015 Dec;21(12):2271-3
pubmed: 26584224
J Infect Dis. 2011 Nov;204 Suppl 3:S757-60
pubmed: 21987747
Virol J. 2012 Oct 13;9:236
pubmed: 23062147
BMC Evol Biol. 2010 Jun 22;10:193
pubmed: 20569424
PLoS Pathog. 2013 Mar;9(3):e1003209
pubmed: 23516359
J Virol. 2013 Mar;87(5):2608-16
pubmed: 23255795
Front Microbiol. 2019 Jul 10;10:1490
pubmed: 31354644
Emerg Infect Dis. 2015 Sep;21(9):1675-7
pubmed: 26291173
N Engl J Med. 2020 May 7;382(19):1832-1842
pubmed: 32441897
J Clin Microbiol. 2007 Jan;45(1):224-6
pubmed: 17079496
Biomed Environ Sci. 2023 Jan 20;36(1):86-93
pubmed: 36650684
Science. 2014 Sep 12;345(6202):1369-72
pubmed: 25214632
PLoS Pathog. 2011 Oct;7(10):e1002304
pubmed: 22039362
Emerg Infect Dis. 2004 Jan;10(1):40-7
pubmed: 15078595
Nature. 2018 Apr;556(7700):197-202
pubmed: 29618816
Nat Rev Microbiol. 2019 May;17(5):261-263
pubmed: 30926957
Am J Trop Med Hyg. 1992 Jun;46(6):664-71
pubmed: 1621890
Epidemiol Infect. 2014 Jun;142(6):1138-45
pubmed: 24040779
Emerg Infect Dis. 2013 Feb;19(2):270-3
pubmed: 23343532
Viruses. 2014 Apr 17;6(4):1759-88
pubmed: 24747773
Nat Rev Microbiol. 2020 Jul;18(7):365-378
pubmed: 32367066