Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results.
IgG4-related disease
Megasphaera
causal relationship
direct linear non-Gaussian acyclic model
gut microbiota
immunoglobulin G4
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2023
2023
Historique:
received:
04
08
2023
accepted:
29
09
2023
medline:
2
11
2023
pubmed:
1
11
2023
entrez:
1
11
2023
Statut:
epublish
Résumé
Immunoglobulin G4 (IgG4) is a member of the human immunoglobulin G (IgG) subclass, a protein involved in immunity to pathogens and the body's resistance system. IgG4-related diseases (IgG4-RD) are intractable diseases in which IgG4 levels in the blood are elevated, causing inflammation in organs such as the liver, pancreas, and salivary glands. IgG4-RD are known to be more prevalent in males than in females, but the etiology remains to be elucidated. This study was conducted to investigate the relationship between gut microbiota (GM) and serum IgG4 levels in the general population. In this study, the relationship between IgG4 levels and GM evaluated in male and female groups of the general population using causal inference. The study included 191 men and 207 women aged 40 years or older from Shika-machi, Ishikawa. GM DNA was analyzed for the 16S rRNA gene sequence using next-generation sequencing. Participants were bifurcated into high and low IgG4 groups, depending on median serum IgG4 levels. ANCOVA, Tukey's HSD, linear discriminant analysis effect size, least absolute shrinkage and selection operator logistic regression model, and correlation analysis revealed that This differential impact of the GM on IgG4 levels based on sex is a novel and intriguing finding.
Identifiants
pubmed: 37908763
doi: 10.3389/fcimb.2023.1272398
pmc: PMC10613983
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1272398Informations de copyright
Copyright © 2023 Koshida, Karashima, Ogura, Miyajima, Ogai, Mizoguchi, Ikagawa, Hara, Mizushima, Fujii, Kawano, Tsujiguchi, Hara, Nakamura and Okamoto.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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