Sulfonium-Cross-Linked Hyaluronic Acid-Based Self-Healing Hydrogel: Stimuli-Responsive Drug Carrier with Inherent Antibacterial Activity to Counteract Antibiotic-Resistant Bacteria.
antibacterial activity
antibiofilm activity
in vivo efficacy
methicillin-resistant Staphylococcus aureus
sulfonium-containing hyaluronic acid-based cross-linked hydrogel
vancomycin-resistant Enterococci
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
01 Nov 2023
01 Nov 2023
Historique:
revised:
22
10
2023
received:
23
08
2023
pubmed:
1
11
2023
medline:
1
11
2023
entrez:
1
11
2023
Statut:
aheadofprint
Résumé
Augmentation of the activity of Food and Drug Administration-approved antibiotics by an adjuvant or antibiotic carrier is considered one of the promising strategies to fight against antibiotic-resistant bacteria. This study reports the development of sulfonium-cross-linked hyaluronic acid (HA)-based polymer (HA-SS-HA) as an inherent antimicrobial agent and antibiotic carrier. The HA-SS-HA polymer offers the potential for encapsulating various classes of antibiotics and accomplishing a stimuli-responsive release profile in the presence of hyaluronidase produced by bacterial cells within their extracellular environment. Systematic antibacterial studies reveal that the HA-SS-HA-encapsulated antibiotics (vancomycin, amoxicillin, and tetracycline) restore its activity against the antibiotic-resistant bacterial cells methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE), and Pseudomonas aeruginosa. The HA-SS-HA gel shows robust efficacy in eradicating the mature biofilm of Staphylococcus aureus (S. aureus). The membrane-disrupting activity reveals that HA-SS-HA can also counteract the antibiotic resistance mechanism of the bacterial cells. The in vivo studies reveal excellent wound-healing activity of HA-SS-HA in albino laboratory-bred (BALB/c) mice. The outcome of additional antibacterial studies reveals that antibiotics-encapsulated HA-SS-HA hydrogel can effectively combat Gram-negative, Gram-positive, and antibiotic-resistant bacterial strains. Therefore, revitalizing the activity of commercial antibiotics by HA-SS-HA can be considered a valuable and economically effective strategy to fight against antibiotic-resistant bacteria.
Identifiants
pubmed: 37909063
doi: 10.1002/adhm.202302790
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2302790Subventions
Organisme : Science & Engineering Research Board
ID : CRG/2021/000306
Organisme : Council of Scientific and Industrial Research, Government of India
ID : 02(420)/21/EMR-II
Informations de copyright
© 2023 Wiley-VCH GmbH.
Références
a) K. E. Jones, N. G. Patel, M. A. Levy, A. Storeygard, D. Balk, J. L. Gittleman, P. Daszak, Nature 2008, 451, 990;
b) C. Willyard, Nature 2017, 543, 15.
a) R. Berndsen, T. Cunningham, L. Kaelin, M. Callender, W. D. Boldog, B. Viering, A. King, N. Labban, J. A. Pollock, H. B. Miller, M. S. Blackledge, ACS Med. Chem. Lett. 2022, 13, 483;
b) R. J. Melander, C. Melander, ACS Infect. Dis. 2017, 3, 559;
c) M. Wei, J. Wu, H. Sun, B. Zhang, X. Hu, Q. Wang, B. Li, L. Xu, T. Ma, J. Gao, F. Li, D. Ling, Small 2023, 19, 2205471;
d) B. M. Prusty, R. Karn, A. Patel, P. Mazumder, S. Kumar, D. Manna, Chem. Commun. 2023, 59, 10624.
C. L. Tooke, P. Hinchliffe, E. C. Bragginton, C. K. Colenso, V. H. A. Hirvonen, Y. Takebayashi, J. Spencer, J. Mol. Biol. 2019, 431, 3472.
a) D. Guan, F. Chen, Y. Qiu, B. Jiang, L. Gong, L. Lan, W. Huang, W. Huang, Angew. Chem., Int. Ed. 2019, 58, 6678;
b) Z.-C. Wu, D. L. Boger, Acc. Chem. Res. 2020, 53, 2587.
V. Yarlagadda, P. Sarkar, S. Samaddar, J. Haldar, Angew. Chem., Int. Ed. 2016, 55, 7836.
a) S. Dey, A. Patel, K. Raina, N. Pradhan, O. Biswas, R. P. Thummer, D. Manna, Chem. Commun. 2020, 56, 1661;
b) A. Patel, S. Dey, K. Shokeen, T. M. Karpinski, S. Sivaprakasam, S. Kumar, D. Manna, RSC Med. Chem. 2021, 12, 1005;
c) A. Patel, S. Paul, N. Akhtar, S. Das, S. Kar, S. Bhattacharjee, D. Manna, ACS Appl. Nano Mater. 2022, 5, 16602.
a) X. Wang, G. Wang, J. Zhao, Z. Zhu, J. Rao, ACS Macro Lett. 2021, 10, 1643;
b) X. Zhao, H. Wu, B. Guo, R. Dong, Y. Qiu, P. X. Ma, Biomaterials 2017, 122, 34.
M. Chen, J. Tian, Y. Liu, H. Cao, R. Li, J. Wang, J. Wu, Q. Zhang, Chem. Eng. J. 2019, 373, 413.
a) H. Du, G. Zha, L. Gao, H. Wang, X. Li, Z. Shen, W. Zhu, Polym. Chem. 2014, 5, 4002;
b) P. Sautrot-Ba, S. Jockusch, T.-T.-T. Nguyen, D. Grande, A. Chiapionne, S. Abbad-Andaloussi, M. Pan, R. Méallet-Renault, D.-L. Versace, Eur. Polym. J. 2020, 138, 109936.
a) W. Boot, T. Schmid, M. D'este, O. Guillaume, A. Foster, L. Decosterd, R. G. Richards, D. Eglin, S. Zeiter, T. F. Moriarty, Antimicrob. Agents Chemother. 2021, 65, e01840;
b) F. Zamboni, C. K. Wong, M. N. Collins, Bioact. Mater. 2023, 19, 458.
N. Mohan, S. S. Pavan, A. Jayakumar, S. Rathinavelu, S. Sivaprakasam, Appl. Microbiol. Biotechnol. 2022, 106, 1079.
K. Mavronasou, A. Zamboulis, P. Klonos, A. Kyritsis, D. N. Bikiaris, R. Papadakis, I. Deligkiozi, Polymers 2022, 14, 804.
S. Dey, S. Das, A. Patel, K. V. Raj, K. Vanka, D. Manna, J. Mater. Chem. A 2022, 10, 4585.
a) M. C. Das, S. Paul, P. Gupta, P. Tribedi, S. Sarkar, D. Manna, S. Bhattacharjee, J. Appl. Microbiol. 2016, 120, 842;
b) S. Dey, A. Patel, N. Haloi, S. Srimayee, S. Paul, G. K. Barik, N. Akhtar, D. Shaw, G. Hazarika, B. M. Prusty, M. Kumar, M. K. Santra, E. Tajkhorshid, S. Bhattacharjee, D. Manna, J. Med. Chem. 2023, 66, 11078.
J. E. Zins, J. N. Grow, Aesthetic Surg. J. 2021, 41, 356.
J. Hoque, M. M. Konai, S. Gonuguntla, G. B. Manjunath, S. Samaddar, V. Yarlagadda, J. Haldar, J. Med. Chem. 2015, 58, 5486.
P. Sarkar, S. Samaddar, V. Ammanathan, V. Yarlagadda, C. Ghosh, M. Shukla, G. Kaul, R. Manjithaya, S. Chopra, J. Haldar, ACS Chem. Biol. 2020, 15, 884.
K. Singh, S. S. Kulkarni, J. Med. Chem. 2022, 65, 8525.
a) M. C. Sousa, Nature 2019, 576, 389;
b) M. Zhou, M. M. Zheng, J. F. Cai, ACS Appl. Mater. Interfaces 2020, 12, 21292.
O. Yushchuk, E. Binda, F. Marinelli, Front. Microbiol. 2020, 11, 1173.
C. Yu, H. Gao, Q. Li, X. Cao, Polym. Chem. 2020, 11, 3169.
K. Roy, G. Pandit, M. Chetia, A. K. Sarkar, S. Chowdhuri, A. P. Bidkar, S. Chatterjee, ACS Appl. Bio Mater. 2020, 3, 6251.
L. Li, B. Yan, J. Yang, W. Huang, L. Chen, H. Zeng, ACS Appl. Mater. Interfaces 2017, 9, 9221.
a) S. Banerjee, K. Vishakha, S. Das, M. Dutta, D. Mukherjee, J. Mondal, S. Mondal, A. Ganguli, Colloids Surf., B 2020, 190, 110921;
b) G. A. Subramenium, D. Viszwapriya, P. M. Iyer, K. Balamurugan, S. K. Pandian, PLoS One 2015, 10, e0127210.
V. Nyigo, R. Mdegela, F. Mabiki, H. Malebo, Eur. J. Med. Plants 2015, 10, 1.
Y. Zheng, Y. Liang, D. Zhang, X. Sun, L. Liang, J. Li, Y.-N. Liu, ACS Omega 2018, 3, 4766.
V. O. Fasiku, C. A. Omolo, N. Devnarain, U. H. Ibrahim, S. Rambharose, M. Faya, C. Mocktar, S. D. Singh, T. Govender, ACS Omega 2021, 6, 21994.