Prognostic role of the MRI-based involvement of superior pharyngeal constrictor muscle in oropharyngeal squamous cell carcinoma.
HPV
squamous cell carcinoma
superior pharyngeal constrictor muscle
surgery
survival
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
revised:
23
08
2023
received:
11
04
2023
accepted:
22
10
2023
pubmed:
1
11
2023
medline:
1
11
2023
entrez:
1
11
2023
Statut:
ppublish
Résumé
The aim of this study was to determine the impact of the involvement of the superior pharyngeal constrictor muscle (SPCM) evaluated by magnetic resonance imaging (MRI) on outcome in oropharyngeal squamous cell carcinomas (OPSCCs). A retrospective study including consecutive patients with OPSCC treated with curative intent. A total of 82 consecutive patients with OPSCC met inclusion criteria. At multivariate analysis, patients with SPCM infiltration were at significantly higher risk of death (HR: 3.37, CI: 1.21-9.38) and progression (HR: 3.39, CI: 1.38-8.32). In a multivariate model conditioned on HPV status, a significantly higher risk of death and progression was observed by combining both SPCM and HPV status with patients harboring an HPV-negative OPSCC with SPCM infiltration showing the poorest outcome. MRI evidence of SPCM involvement significantly and independently increases the risk of death and progression in subjects with OPSCC. Considering both MRI-assessed SPCM infiltration and HPV status significantly improved risk stratification in these malignancies.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-170Informations de copyright
© 2023 The Authors. Head & Neck published by Wiley Periodicals LLC.
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