Ferruginoside D: A Novel Phenylethanoid from Verbascum leiocarpum.
Verbascum leiocarpum
antioxidant activity
antiproliferative activity
secondary metabolite
α-glucosidase inhibitory
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
01 Nov 2023
01 Nov 2023
Historique:
received:
09
08
2023
accepted:
31
10
2023
pubmed:
1
11
2023
medline:
1
11
2023
entrez:
1
11
2023
Statut:
aheadofprint
Résumé
A novel phenylethanoid, ferruginoside D, together with fourteen known compounds were isolated from the Verbascum leiocarpum for the first time. Chemical structures of isolated compounds were determined by spectroscopic analysis including HR-ESI-MS and NMR spectra. The antioxidant, α-glucosidase inhibitory properties, and antiproliferative activities against multiple cell lines (A172, C6, HeLa, A2780, SW620, HT29, Beas2B, RPE, and HSF) of the isolated compounds were evaluated in vitro. According to the results, iridoids, flavonoids (luteolin and apigenin), and phenylethanoids (poliumoside and isoverbascoside) with strong antiproliferative potential were also found to have cytostatic effects. Furthermore, the investigation revealed that compounds luteolin, poliumoside, verbascoside, isoverbascoside, ferruginoside C, ferruginoside D, and ursolic acid show potent alpha-glucosidase inhibitory activity, while compounds luteolin, verbascoside, and isoverbascoside exhibit substantial antioxidant activity. The new compound (ferruginoside D) was found moderately active against cancer cell lines, with strong alpha-glucosidase inhibitory activity, and moderate antioxidant properties.
Identifiants
pubmed: 37909246
doi: 10.1002/cbdv.202301200
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202301200Subventions
Organisme : NMR
Organisme : LC-TOF/MS
Informations de copyright
© 2023 Wiley-VHCA AG, Zurich, Switzerland.
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