Acute reorganization of postsynaptic GABA

Receptors, GABA-A Synapses / physiology Carrier Proteins Receptors, Neurotransmitter gamma-Aminobutyric Acid
CP: Neuroscience CRY2 GABA(A) receptor gephyrin inhibitory synapse nanocolumn optogenetics superresolution microscopy

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
28 Nov 2023
Historique:
received: 02 06 2023
revised: 01 09 2023
accepted: 06 10 2023
medline: 4 12 2023
pubmed: 1 11 2023
entrez: 1 11 2023
Statut: ppublish

Résumé

Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites. While spatial coordination between pre- and postsynaptic elements is observed at both excitatory and inhibitory synapses, the functional significance of this molecular architecture has been challenging to evaluate experimentally. Here we utilized an optogenetic clustering approach to acutely alter the nanoscale organization of the postsynaptic inhibitory scaffold gephyrin while monitoring synaptic function. Gephyrin clustering rapidly enlarged postsynaptic area, laterally displacing GABA

Identifiants

DOI: 10.1016/j.celrep.2023.113331 PMID: 37910506
pubmed: 37910506
pii: S2211-1247(23)01343-8
doi: 10.1016/j.celrep.2023.113331
pii:
doi:

Substances chimiques

Receptors, GABA-A 0
Carrier Proteins 0
Receptors, Neurotransmitter 0
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113331

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Samantha S Olah (SS)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Dean J Kareemo (DJ)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

William C Buchta (WC)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Brooke L Sinnen (BL)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Carley N Miller (CN)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Hannah S Actor-Engel (HS)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Sara E Gookin (SE)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Christina S Winborn (CS)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Mason S Kleinjan (MS)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Kevin C Crosby (KC)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Jason Aoto (J)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Katharine R Smith (KR)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Matthew J Kennedy (MJ)

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: matthew.kennedy@cuanschutz.edu.

Articles similaires

Myosin-binding protein-H: Not just filler.

David Y Barefield
1.00
Animals Humans Sarcomeres Muscle Proteins Carrier Proteins

Clinical significance of peripheral blood DDR1 and CtBP gene methylation detection in patients with acute pancreatitis.

Zeng-Hui Ma, Xue-Ni Ma, Hong-Wen Zhu et al.
1.00
Humans DNA Methylation Female Male Alcohol Oxidoreductases

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.

Jerika J Barron, Nicholas M Mroz, Sunrae E Taloma et al.
1.00
Animals Mice Immunity, Innate Interneurons Synapses

Synaptic interactions between stellate cells and parvalbumin interneurons in layer 2 of the medial entorhinal cortex are organized at the scale of grid cell clusters.

Li-Wen Huang, Derek L F Garden, Christina McClure et al.
1.00
Animals Entorhinal Cortex Interneurons Parvalbumins Mice

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-A › Acute reorganization of postsynaptic GABA
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Acute reorganization of postsynaptic GABA
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Acute reorganization of postsynaptic GABA
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Acute reorganization of postsynaptic GABA
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Acute reorganization of postsynaptic GABA