Effect of Poly(Vinyl Pyrrolidone) on Iodine Release from Acrylate-Endcapped Urethane-Based Poly(Ethylene Glycol) Hydrogels as Antibacterial Wound Dressing.
antibacterial materials
iodine
mechanical strength
poly(ethylene glycol)
poly(vinyl pyrrolidone)
swelling
wound dressing
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
01 Nov 2023
01 Nov 2023
Historique:
revised:
11
09
2023
received:
10
05
2023
pubmed:
2
11
2023
medline:
2
11
2023
entrez:
1
11
2023
Statut:
aheadofprint
Résumé
Infections are still a major cause of morbidity in burn wounds. Although silver has been used strongly in past centuries as an anti-bacterial, it can lead to allergic reactions, bacterial resistance, and delayed wound healing. Iodine-based antibacterials are becoming an interesting alternative. In this work, the effect of complexation with poly(vinyl pyrrolidone) (PVP) and poly(ethylene oxide) (PEO)-based polymers is explored by using different acrylate-endcapped urethane-based poly(ethylene glycol) (AUP) polymers, varying the molar mass (MM) of the poly(ethylene glycol) (PEG) backbone, with possible addition of PVP. The higher MM AUP outperforms the swelling potential of commercial wound dressings such as Kaltostat, Aquacel Ag, and Hydrosorb and all MM show superior mechanical properties. The addition of iodine to the polymers is compared to Iso-Betadine Tulle (IBT). Interestingly, the addition of PVP does not lead to increased iodine complexation compared to the blank AUP polymers, while all have a prolonged iodine release compared to the IBT, which leads to a burst release. The observed prolonged release also leads to larger inhibition zones during antibacterial tests. Complexing iodine in AUP polymers with or without PVP leads to antimicrobial wound dressings which may hold potential for future application to treat infected wounds.
Identifiants
pubmed: 37913549
doi: 10.1002/mabi.202300202
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300202Subventions
Organisme : FWO
ID : G075621N
Organisme : FWO
ID : 12Z2918N
Organisme : IOF
ID : F2018/IOF-Advanced/447
Informations de copyright
© 2023 Wiley-VCH GmbH.
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