Layer 1 neocortex: Gating and integrating multidimensional signals.

cortex dendrite inhibitory interneuron integration layer 1 neuromodulation sensory cortex state top-down

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
26 Oct 2023
Historique:
received: 24 07 2023
revised: 23 09 2023
accepted: 28 09 2023
medline: 2 11 2023
pubmed: 2 11 2023
entrez: 1 11 2023
Statut: aheadofprint

Résumé

Layer 1 (L1) of the neocortex acts as a nexus for the collection and processing of widespread information. By integrating ascending inputs with extensive top-down activity, this layer likely provides critical information regulating how the perception of sensory inputs is reconciled with expectation. This is accomplished by sorting, directing, and integrating the complex network of excitatory inputs that converge onto L1. These signals are combined with neuromodulatory afferents and gated by the wealth of inhibitory interneurons that either are embedded within L1 or send axons from other cortical layers. Together, these interactions dynamically calibrate information flow throughout the neocortex. This review will primarily focus on L1 within the primary sensory cortex and will use these insights to understand L1 in other cortical areas.

Identifiants

DOI: 10.1016/j.neuron.2023.09.041 PMID: 37913772
pubmed: 37913772
pii: S0896-6273(23)00754-7
doi: 10.1016/j.neuron.2023.09.041
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests G.F. is a founder of Regel Therapeutics, which has no competing interests with the present manuscript, and an advisor for the McKnight Foundation, Neuron, and Annual Review of Neuroscience.

Auteurs

Shuhan Huang (S)

Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA; Program in Neuroscience, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Sherry Jingjing Wu (SJ)

Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Giulia Sansone (G)

Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia.

Leena Ali Ibrahim (LA)

Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia. Electronic address: leena.ibrahim@kaust.edu.sa.

Gord Fishell (G)

Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: gordon_fishell@hms.harvard.edu.

Classifications MeSH