Philadelphia chromosome-negative myeloproliferative chronic neoplasms: is clonal hematopoiesis the main determinant of autoimmune and cardio-vascular manifestations?
CHIP
DNMT3A
JAK2
ROCK2
TET2
autoimmune disease
cardiovascular disease
myeloproliferative neoplasms
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
07
2023
accepted:
19
09
2023
medline:
2
11
2023
pubmed:
2
11
2023
entrez:
2
11
2023
Statut:
epublish
Résumé
In this article, we reviewed the possible mechanisms linking the clonal hematopoiesis of indeterminate potential (CHIP) to chronic myeloproliferative neoplasms (MPNs), autoimmune diseases (ADs), and cardiovascular diseases (CADs). CHIP is characterized by the presence of clonal mutations with an allelic frequency >2% in the peripheral blood without dysplasia, overt hematological neoplasms, or abnormalities in blood cell count. The prevalence may reach 20% of elderly healthy individuals and is considered a risk factor for myelodysplastic neoplasms and acute leukemia. In MPNs, CHIP is often associated with mutations such as
Identifiants
pubmed: 37915324
doi: 10.3389/fmed.2023.1254868
pmc: PMC10616863
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1254868Informations de copyright
Copyright © 2023 Fulvio, Baldini, Mosca, di Paolo, Bocci, Palumbo, Cacciola, Migliorini, Cacciola and Galimberti.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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