Augmented thrombin formation is related to circulating levels of extracellular vesicles exposing tissue factor and citrullinated histone-3 in anti-neutrophil cytoplasmic antibody-associated vasculitides.
NETs
anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
extracellular vesicles
thrombin generation
tissue factor
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2023
2023
Historique:
received:
14
06
2023
accepted:
29
09
2023
medline:
2
11
2023
pubmed:
2
11
2023
entrez:
2
11
2023
Statut:
epublish
Résumé
To study circulating myeloperoxidase (MPO)-positive extracellular vesicles (MPO We have involved well-characterized patients with AAV together with population-based controls. Flow cytometry was used to assess the levels of MPO This study comprised 46 AAV patients, 23 in the active stage of the disease and 23 in remission, as well as 23 age- and sex matched population-based controls. Augmented levels of all investigated MPO Augmented thrombin generation is found in AAV patients regardless of disease activity and is associated with higher exposure of TF and H3Cit on MPO
Identifiants
pubmed: 37915326
doi: 10.3389/fmed.2023.1240325
pmc: PMC10616855
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1240325Informations de copyright
Copyright © 2023 Jonasdottir, Manojlovic, Vojinovic, Nordin, Bruchfeld, Gunnarsson, Mobarrez and Antovic.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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