Corneal immune cells as a biomarker of inflammation in multiple sclerosis: a longitudinal study.
biomarker
corneal confocal microscopy
inflammation
multiple sclerosis
neurodegeneration
Journal
Therapeutic advances in neurological disorders
ISSN: 1756-2856
Titre abrégé: Ther Adv Neurol Disord
Pays: England
ID NLM: 101480242
Informations de publication
Date de publication:
2023
2023
Historique:
received:
05
06
2023
accepted:
12
09
2023
medline:
2
11
2023
pubmed:
2
11
2023
entrez:
2
11
2023
Statut:
epublish
Résumé
Corneal immune cells (ICs) are antigen-presenting cells that are known to increase ocular and systemic inflammatory conditions. We aimed to assess longitudinal changes in corneal IC in patients with multiple sclerosis (MS) and relation to disability and ongoing treatment. Prospective observational study conducted between September 2016 and February 2020. Patients with relapsing-remitting MS (RRMS) ( In both RRMS and SPMS compared to controls, DCP ( Baseline and change in corneal IC were related to axonal degeneration and treatment status. Evaluation of corneal IC using CCM may allow an assessment of ongoing inflammation, disease progression, and the effect of treatment in MS.
Sections du résumé
Background
UNASSIGNED
Corneal immune cells (ICs) are antigen-presenting cells that are known to increase ocular and systemic inflammatory conditions.
Objective
UNASSIGNED
We aimed to assess longitudinal changes in corneal IC in patients with multiple sclerosis (MS) and relation to disability and ongoing treatment.
Design
UNASSIGNED
Prospective observational study conducted between September 2016 and February 2020.
Methods
UNASSIGNED
Patients with relapsing-remitting MS (RRMS) (
Results
UNASSIGNED
In both RRMS and SPMS compared to controls, DCP (
Conclusion
UNASSIGNED
Baseline and change in corneal IC were related to axonal degeneration and treatment status. Evaluation of corneal IC using CCM may allow an assessment of ongoing inflammation, disease progression, and the effect of treatment in MS.
Identifiants
pubmed: 37915502
doi: 10.1177/17562864231204974
pii: 10.1177_17562864231204974
pmc: PMC10617262
doi:
Types de publication
Journal Article
Langues
eng
Pagination
17562864231204974Informations de copyright
© The Author(s), 2023.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest.
Références
Mult Scler. 2017 Dec;23(14):1847-1853
pubmed: 27811337
Ther Adv Neurol Disord. 2023 Feb 6;16:17562864221118731
pubmed: 36776530
J Nucl Med. 2017 Sep;58(9):1477-1482
pubmed: 28302760
Ann Neurol. 2011 Feb;69(2):292-302
pubmed: 21387374
J Leukoc Biol. 2003 Aug;74(2):172-8
pubmed: 12885933
Invest Ophthalmol Vis Sci. 2014 Mar 03;55(3):1313-20
pubmed: 24458151
Transl Vis Sci Technol. 2020 Dec 21;9(13):37
pubmed: 33384891
Transl Vis Sci Technol. 2021 Apr 1;10(4):19
pubmed: 34003997
Sci Rep. 2021 Nov 4;11(1):21688
pubmed: 34737384
Curr Eye Res. 2021 Oct;46(10):1452-1459
pubmed: 33734930
Neurochem Res. 2014 Jan;39(1):1-36
pubmed: 24258018
J Exp Med. 2002 Jan 21;195(2):259-68
pubmed: 11805152
Neurology. 2015 Jul 7;85(1):18-28
pubmed: 25888557
Brain. 1997 Mar;120 ( Pt 3):393-9
pubmed: 9126051
Optom Vis Sci. 2015 Sep;92(9):e290-5
pubmed: 25909241
Ann Clin Transl Neurol. 2015 Dec 28;3(2):88-100
pubmed: 26900579
Am J Ophthalmol. 2023 Jun;250:138-148
pubmed: 36669610
Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3677-3681
pubmed: 28727882
Int J Mol Sci. 2018 Sep 11;19(9):
pubmed: 30208620
JAMA Ophthalmol. 2017 Jul 1;135(7):777-782
pubmed: 28570722
Ann Neurol. 2019 May;85(5):618-629
pubmed: 30851125
Cornea. 2020 Oct;39(10):1221-1226
pubmed: 32732697
Mult Scler Relat Disord. 2018 Nov;26:173-182
pubmed: 30268038
Ophthalmology. 2015 Apr;122(4):662-8
pubmed: 25542519
J Neuroinflammation. 2021 Apr 8;18(1):89
pubmed: 33832507
Transl Vis Sci Technol. 2021 Dec 1;10(14):10
pubmed: 34905000
Front Immunol. 2020 May 07;11:742
pubmed: 32457740
Brain. 2017 Mar 1;140(3):527-546
pubmed: 27794524
Front Pain Res (Lausanne). 2021 Aug 19;2:725363
pubmed: 35295436
Mult Scler. 2014 Dec;20(14):1806-13
pubmed: 25122475
Ocul Immunol Inflamm. 2020 Aug 17;28(6):898-907
pubmed: 31429614
Brain. 2009 May;132(Pt 5):1175-89
pubmed: 19339255
AJNR Am J Neuroradiol. 2016 Aug;37(8):1447-53
pubmed: 26939635
Diagnostics (Basel). 2022 May 09;12(5):
pubmed: 35626335
Magn Reson Med. 1991 Feb;17(2):357-67
pubmed: 2062210
CNS Drugs. 2018 Mar;32(3):229-240
pubmed: 29508245
Sci Rep. 2022 Jul 1;12(1):11167
pubmed: 35778532
Neurology. 2005 Apr 12;64(7):1144-51
pubmed: 15824338
Invest Ophthalmol Vis Sci. 2011 Jul 11;52(8):5136-43
pubmed: 21460259
Handb Clin Neurol. 2014;122:15-58
pubmed: 24507512
Sci Rep. 2021 Nov 24;11(1):22884
pubmed: 34819589
Nat Rev Neurol. 2019 Oct;15(10):582-593
pubmed: 31420598
Mult Scler. 2017 Oct;23(11):1469-1478
pubmed: 27903933
Sci Rep. 2021 Jul 26;11(1):15150
pubmed: 34312451
Prog Retin Eye Res. 2021 Jan;80:100877
pubmed: 32717378
Invest Ophthalmol Vis Sci. 2014 Apr 03;55(4):2071-8
pubmed: 24569580
Biochim Biophys Acta. 2011 Feb;1812(2):252-64
pubmed: 20619340
Innate Immun. 2013;19(4):420-7
pubmed: 23339928
Diagnostics (Basel). 2021 May 07;11(5):
pubmed: 34066952
Nat Clin Pract Neurol. 2008 Dec;4(12):664-75
pubmed: 19043423
Ocul Surf. 2021 Jul;21:186-192
pubmed: 34102312
Invest Ophthalmol Vis Sci. 2014 Oct 16;55(11):7457-66
pubmed: 25324281