Transsphenoidal hypophysectomy for the treatment of hypersomatotropism secondary to a pituitary somatotroph adenoma in a dog.
acromegaly
canine
endocrine
growth hormone
insulin-like growth factor-1
surgery
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
02 Nov 2023
02 Nov 2023
Historique:
received:
03
07
2023
accepted:
19
10
2023
medline:
2
11
2023
pubmed:
2
11
2023
entrez:
2
11
2023
Statut:
aheadofprint
Résumé
Pituitary-dependent hypersomatotropism is rarely diagnosed in dogs and surgical treatment is not reported. A 6-year-10-month male neutered Patterdale Terrier presented with polyuria, polydipsia, progressive pharyngeal stertor, excessive hair growth and widened facial features and paws. Serum insulin-like growth factor-1 concentration via radioimmunoassay was consistent with hypersomatotropism (1783 ng/mL). A pituitary mass was identified on magnetic resonance and computed tomography imaging. Six weeks later, glucosuria, starved hyperglycemia and serum fructosamine above the reference range (467.6 μmol/L, RI 177-314) were documented, consistent with diabetes mellitus. Transsphenoidal hypophysectomy was performed under general anesthesia without complications. Pituitary histopathology identified an acidophil neoplasm, with positive immunostaining for growth hormone. Postoperatively, there was rapid resolution of clinical, biochemical and morphologic changes of hypersomatotropism with persistence of diabetes mellitus. This case demonstrates successful resolution of hypersomatotropism with ongoing diabetes mellitus in a dog after surgical treatment by transsphenoidal hypophysectomy.
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
Références
Gouvêa FN, Pennacchi CS, Assaf ND, et al. Acromegaly in dogs and cats. Ann Endocrinol. 2021;82(2):107-111.
Zublena F, Tamborini A, Mooney CT, et al. Radiotherapy and pasireotide treatment of a growth hormone producing pituitary tumor in a diabetic dog. Can Vet J. 2018;59(10):1089-1093.
Van Keulen LJM, Wesdorp JL, Kooistra HS. Diabetes mellitus in a dog with a growth hormone-producing acidophilic adenoma of the adenohypophysis. Vet Pathol. 1996;33(4):451-453.
Reusch C, Burkhardt WA, Meier VS, et al. Acromegaly due to a pituitary tumor in a dog-diagnosis, therapy and long-term follow-up. Schweiz Arch Tierheilkd. 2019;161(5):319-327.
Meij BP, Voorhout G, Van den Ingh TS, et al. Transsphenoidal hypophysectomy in beagle dogs: evaluation of a microsurgical technique. Vet Surg. 1997;26(4):295-309.
Fenn J, Kenny PJ, Scudder CJ, et al. Efficacy of hypophysectomy for the treatment of hypersomatotropism-induced diabetes mellitus in 68 cats. J Vet Intern Med. 2021;35(2):823-833.
Scudder CJ, Mirczuk SM, Richardson KM, et al. Pituitary pathology and gene expression in acromegalic cats. J Endocr Soc. 2019;3(1):181-200.
Fracassi F, Gandini G, Diana A, et al. Acromegaly due to a somatroph adenoma in a dog. Domest Anim Endocrinol. 2007;32(1):43-54.
Asa SL, Mete O, Perry A, Osamura RY. Overview of the 2022 WHO classification of pituitary tumors. Endocr Pathol. 2022;33(1):6-26.
Syro LV, Rotondo F, Serna CA, Ortiz LD, Kovacs K. Pathology of GH-producing pituitary adenomas and GH cell hyperplasia of the pituitary. Pituitary. 2017;20(1):84-92.
Sharman M, Fitzgerald L, Kiupel M. Concurrent somatotroph and plurihormonal pituitary adenomas in a cat. J Feline Med Surg. 2013;15(10):945-952.
Sanders K, Galac S, Meij BP. Pituitary tumour types in dogs and cats. Vet J. 2021;270:105623.
Meij BP, Van Der Vlugt-Meijer RH, Van Den Ingh TSGAM, et al. Somatotroph and corticotroph pituitary adenoma (double adenoma) in a cat with diabetes mellitus and hyperadrenocorticism. J Comp Pathol. 2004;130(2-3):209-215.
Lamb CR, Ciasca TC, Mantis P, et al. Computed tomographic signs of acromegaly in 68 diabetic cats with hypersomatotropism. J Feline Med Surg. 2014;16:99-108.
Katznelson L, Laws ER, Melmed S, et al. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014;99:3933-3951.
Meij BP, Auriemma E, Grinwis G, Buijtels JJCWM, Kooistra HS. Successful treatment of acromegaly in a diabetic cat with transsphenoidal hypophysectomy. J Feline Med Surg. 2010;12(5):406-410.
van Bokhorst KL, Galac S, Kooistra HS, et al. Evaluation of hypophysectomy for treatment of hypersomatotropism in 25 cats. J Vet Intern Med. 2021;35(2):834-842.
Hanson JM, van 't Hooft HM, Voorhout G, et al. Efficacy of transsphenoidal hypophysectomy in treatment of dogs with pituitary-dependent hyperadrenocorticism. J Vet Intern Med. 2005;19:687-694.
Owen TJ, Martin LG, Chen AV. Transsphenoidal surgery for pituitary tumors and other sellar masses. Vet Clin North Am Small Anim Pract. 2018;48(1):129-151.
Hyde BR, Martin LG, Chen AV. Clinical characteristics and outcome in 15 dogs treated with transsphenoidal hypophysectomy for nonfunctional sellar masses. Vet Surg. 2023;52(1):69-80.
Wormhoudt TL, Boss MK, Lunn K, et al. Stereotactic radiation therapy for the treatment of functional pituitary adenomas associated with feline acromegaly. J Vet Intern Med. 2018;32(4):1383-1391.
Watson-Skaggs ML, Gieger TL, Yoshikawa H, Nolan MW. Endocrine response and outcome in 14 cats with insulin resistance and acromegaly treated with stereotactic radiosurgery (17 Gy). Am J Vet Res. 2022;83(1):64-71.
Ogedegbe OJ, Cheema AY, Khan MA, et al. A comprehensive review of four clinical practice guidelines of acromegaly. Cureus. 2022;14(9):1-8.
Scudder CJ, Gostelow R, Forcada Y, Schmid HA, Church D, Niessen SJM. Pasireotide for the medical management of feline hypersomatotropism. J Vet Intern Med. 2015;29(4):1074-1080.
Gostelow R, Scudder C, Keyte S, et al. Pasireotide long-acting release treatment for diabetic cats with underlying hypersomatotropism. J Vet Intern Med. 2017;31(2):355-364.
Miceli DD, García JD, Pompili GA, et al. Cabergoline treatment in cats with diabetes mellitus and hypersomatotropism. J Feline Med Surg. 2022;24(12):1238-1244.
Scudder CJ, Hazuchova K, Gostelow R, et al. Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus. J Feline Med Surg. 2021;23(2):131-137.
Meij BP, Voorhout G, Van Den Ingh TSGAM, et al. Results of transsphenoidal hypophysectomy in 52 dogs with pituitary-dependent hyperadrenocorticism. Vet Surg. 1998;27(3):246-261.
Niessen SJM, Forcada Y, Mantis P, et al. Studying cat (Felis catus) diabetes: beware of the acromegalic imposter. PloS One. 2015;10(5):e0127794.
Fracassi F, Zagnoli L, Rosenberg D, Furlanello T, Caldin M. Spontaneous acromegaly: a retrospective case control study in German shepherd dogs. Vet J. 2014;202(1):69-75.