Thoracic Aortic Volume as a Predictor of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis.
aortic arch
ascending aorta
cardiac magnetic resonance imaging
descending aorta
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
02 Nov 2023
02 Nov 2023
Historique:
revised:
17
10
2023
received:
11
08
2023
accepted:
17
10
2023
medline:
2
11
2023
pubmed:
2
11
2023
entrez:
2
11
2023
Statut:
aheadofprint
Résumé
It is unclear whether thoracic aortic volume (TAV) is useful for cardiovascular (CV) disease prognosis and risk assessment. This study evaluated cross-sectional associations of TAV with CV risk factors, and longitudinal association with incident CV events in the multiethnic study of atherosclerosis. Retrospective cohort analysis of prospective data. 1182 participants (69 ± 9 years, 54% female, 37% Caucasian, 18% Chinese, 31% African American, 14% Hispanic, 60% hypertensive, and 20% diabetic) without prior CV disease. Axial black-blood turbo spin echo or bright blood steady-state free precession images on 1.5T scanners. TAV was calculated using Simpson's method from axial images, and included the ascending arch and descending segments. Traditional CV risk factors were assessed at the time of MRI. CV outcomes over a 9-year follow-up period were recorded and represented a composite of stroke, stroke death, coronary heart disease (CHD), CHD death, atherosclerotic death, and CVD death. Multivariable linear regression models adjusted for height and weight were used to determine the relationship (β coefficient) between TAV and CV risk factors. Cox regression models assessed the association of TAV and incident CV events. A P-value of <0.05 was deemed statistically significant. Mean TAV was = 139 ± 41 mL. In multivariable regression, TAV was directly associated with age (β = 1.6), male gender (β = 23.9), systolic blood pressure (β = 0.1), and hypertension medication use (β = 7.9); and inversely associated with lipid medication use (β = -5.3) and treated diabetes (β = -8.9). Compared to Caucasians, Chinese Americans had higher TAV (β = 11.4), while African Americans had lower TAV (β = -7.0). Higher TAV was independently associated with incident CV events (HR: 1.057 per 10 mL). Greater TAV is associated with incident CV events, increased age, and hypertension in a large multiethnic population while treated diabetes and lipid medication use were associated with lower TAV. 2 TECHNICAL EFFICACY: Stage 2.
Sections du résumé
BACKGROUND
BACKGROUND
It is unclear whether thoracic aortic volume (TAV) is useful for cardiovascular (CV) disease prognosis and risk assessment.
PURPOSE
OBJECTIVE
This study evaluated cross-sectional associations of TAV with CV risk factors, and longitudinal association with incident CV events in the multiethnic study of atherosclerosis.
STUDY TYPE
METHODS
Retrospective cohort analysis of prospective data.
POPULATION
METHODS
1182 participants (69 ± 9 years, 54% female, 37% Caucasian, 18% Chinese, 31% African American, 14% Hispanic, 60% hypertensive, and 20% diabetic) without prior CV disease.
FIELD STRENGTH AND SEQUENCES
UNASSIGNED
Axial black-blood turbo spin echo or bright blood steady-state free precession images on 1.5T scanners.
ASSESSMENT
RESULTS
TAV was calculated using Simpson's method from axial images, and included the ascending arch and descending segments. Traditional CV risk factors were assessed at the time of MRI. CV outcomes over a 9-year follow-up period were recorded and represented a composite of stroke, stroke death, coronary heart disease (CHD), CHD death, atherosclerotic death, and CVD death.
STATISTICAL TESTS
METHODS
Multivariable linear regression models adjusted for height and weight were used to determine the relationship (β coefficient) between TAV and CV risk factors. Cox regression models assessed the association of TAV and incident CV events. A P-value of <0.05 was deemed statistically significant.
RESULTS
RESULTS
Mean TAV was = 139 ± 41 mL. In multivariable regression, TAV was directly associated with age (β = 1.6), male gender (β = 23.9), systolic blood pressure (β = 0.1), and hypertension medication use (β = 7.9); and inversely associated with lipid medication use (β = -5.3) and treated diabetes (β = -8.9). Compared to Caucasians, Chinese Americans had higher TAV (β = 11.4), while African Americans had lower TAV (β = -7.0). Higher TAV was independently associated with incident CV events (HR: 1.057 per 10 mL).
CONCLUSION
CONCLUSIONS
Greater TAV is associated with incident CV events, increased age, and hypertension in a large multiethnic population while treated diabetes and lipid medication use were associated with lower TAV.
LEVEL OF EVIDENCE
METHODS
2 TECHNICAL EFFICACY: Stage 2.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCATS NIH HHS
ID : UL1-TR-000040
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1-TR-001079
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1-TR-001420
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01-HC-95159
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01-HC-95160
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01-HC-95161
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01-HC-95162
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01-HC-95163
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01-HC-95164
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01-HC-95165
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01-HC-95166
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01-HC-95167
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01-HC-95168
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01-HC-95169
Pays : United States
Informations de copyright
© 2023 International Society for Magnetic Resonance in Medicine.
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