Understanding fluconazole tolerance in Candida albicans: implications for effective treatment of candidiasis and combating invasive fungal infections.
Candida albicans
Fluconazole synergistic lethal adjuvants
Fluconazole synergistic lethal targets
Fluconazole tolerance
Invasive fungal disease
Journal
Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
04
05
2023
revised:
07
10
2023
accepted:
22
10
2023
medline:
4
12
2023
pubmed:
3
11
2023
entrez:
2
11
2023
Statut:
ppublish
Résumé
Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal diseases (IFDs) caused by Candida species. However, the mechanisms of FLC tolerance in Candida species remain to be fully explored. This review discusses the high incidence of FLC tolerance in Candida species and the importance of successfully clearing FLC tolerance in treating candidiasis. We further define and characterize FLC tolerance in C. albicans. This review identifies global factors affecting FLC tolerance and suggest that FLC tolerance is a strategy of C. albicans response to FLC damage whose mechanism differs from FLC resistance. This review highlights the significance of the cell membrane and cell wall integrity in FLC tolerance, guiding approaches to combat IFDs caused by Candida species..
Identifiants
pubmed: 37918789
pii: S2213-7165(23)00188-1
doi: 10.1016/j.jgar.2023.10.019
pii:
doi:
Substances chimiques
Fluconazole
8VZV102JFY
Antifungal Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
314-321Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.