Innate immunity: the bacterial connection.
ATP nucleosidase
CBASS
ISG15
NLR
SAMHD1
TIR
bacterial defense
cGAS-STING
cGLR
gasdermin
inflammasomme
innate immunity
phage
viperin
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
05
10
2023
revised:
07
10
2023
accepted:
07
10
2023
medline:
27
11
2023
pubmed:
3
11
2023
entrez:
2
11
2023
Statut:
ppublish
Résumé
Pathogens have fueled the diversification of intracellular defense strategies that collectively define cell-autonomous innate immunity. In bacteria, innate immunity is manifested by a broad arsenal of defense systems that provide protection against bacterial viruses, called phages. The complexity of the bacterial immune repertoire has only been realized recently and is now suggesting that innate immunity has commonalities across the tree of life: many components of eukaryotic innate immunity are found in bacteria where they protect against phages, including the cGAS-STING pathway, gasdermins, and viperins. Here, I summarize recent findings on the conservation of innate immune pathways between prokaryotes and eukaryotes and hypothesize that bacterial defense mechanisms can catalyze the discovery of novel molecular players of eukaryotic innate immunity.
Identifiants
pubmed: 37919213
pii: S1471-4906(23)00208-9
doi: 10.1016/j.it.2023.10.001
pii:
doi:
Substances chimiques
Nucleotidyltransferases
EC 2.7.7.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
945-953Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declarations of interest No interests are declared.