Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells.
Journal
Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
01
11
2021
accepted:
26
09
2023
pubmed:
3
11
2023
medline:
3
11
2023
entrez:
3
11
2023
Statut:
ppublish
Résumé
Skeletal muscle stem and progenitor cells including those derived from human pluripotent stem cells (hPSCs) offer an avenue towards personalized therapies and readily fuse to form human-mouse myofibres in vivo. However, skeletal muscle progenitor cells (SMPCs) inefficiently colonize chimeric stem cell niches and instead associate with human myofibres resembling foetal niches. We hypothesized competition with mouse satellite cells (SCs) prevented SMPC engraftment into the SC niche and thus generated an SC ablation mouse compatible with human engraftment. Single-nucleus RNA sequencing of SC-ablated mice identified the absence of a transient myofibre subtype during regeneration expressing Actc1. Similarly, ACTC1
Identifiants
pubmed: 37919520
doi: 10.1038/s41556-023-01271-0
pii: 10.1038/s41556-023-01271-0
pmc: PMC10709143
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1758-1773Subventions
Organisme : NIAMS NIH HHS
ID : T32 AR065972
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR064327
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016042
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI028697
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001416
Pays : United States
Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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