Associations between apolipoprotein B and bone mineral density: a population-based study.
Apolipoprotein B
Bone mineral density
Cross-sectional study
NHANES
Osteoporosis
Journal
BMC musculoskeletal disorders
ISSN: 1471-2474
Titre abrégé: BMC Musculoskelet Disord
Pays: England
ID NLM: 100968565
Informations de publication
Date de publication:
02 Nov 2023
02 Nov 2023
Historique:
received:
25
02
2023
accepted:
25
10
2023
medline:
6
11
2023
pubmed:
3
11
2023
entrez:
3
11
2023
Statut:
epublish
Résumé
Lipids are critical in bone metabolism, and several studies have highlighted their importance. This study aimed to investigate the relationship between apolipoprotein B (apo B) and bone mineral density (BMD) at different skeletal sites (lumbar spine, femoral neck, and total femur) and to compare the influence of apo B with other traditional lipid markers. The study included participants from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2016 who had complete data for apo B and BMD at the three skeletal sites. We used weighted multivariate regression analysis, subgroup analysis, and interaction tests to examine associations. Restricted cubic spline (RCS) was used to examine the non-linear relationship. A total of 4,258 adults were included in the study. Multivariate linear regression analysis showed that the relationship between apo B and BMD varied by skeletal site: a negative association was found with lumbar spine BMD [β = -0.054, 95%CI: (-0.073, -0.035)]. In contrast, a positive association was found with femoral neck BMD [β = 0.031, 95%CI: (0.011, 0.051)] and no significant association between apo B and total femur BMD. Our findings suggest that apo B is associated with BMD in a site-specific manner.
Sections du résumé
BACKGROUND
BACKGROUND
Lipids are critical in bone metabolism, and several studies have highlighted their importance. This study aimed to investigate the relationship between apolipoprotein B (apo B) and bone mineral density (BMD) at different skeletal sites (lumbar spine, femoral neck, and total femur) and to compare the influence of apo B with other traditional lipid markers.
METHODS
METHODS
The study included participants from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2016 who had complete data for apo B and BMD at the three skeletal sites. We used weighted multivariate regression analysis, subgroup analysis, and interaction tests to examine associations. Restricted cubic spline (RCS) was used to examine the non-linear relationship.
RESULTS
RESULTS
A total of 4,258 adults were included in the study. Multivariate linear regression analysis showed that the relationship between apo B and BMD varied by skeletal site: a negative association was found with lumbar spine BMD [β = -0.054, 95%CI: (-0.073, -0.035)]. In contrast, a positive association was found with femoral neck BMD [β = 0.031, 95%CI: (0.011, 0.051)] and no significant association between apo B and total femur BMD.
CONCLUSIONS
CONCLUSIONS
Our findings suggest that apo B is associated with BMD in a site-specific manner.
Identifiants
pubmed: 37919727
doi: 10.1186/s12891-023-06990-x
pii: 10.1186/s12891-023-06990-x
pmc: PMC10621203
doi:
Substances chimiques
Apolipoproteins B
0
APOB protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
861Informations de copyright
© 2023. The Author(s).
Références
Calcif Tissue Int. 2020 Mar;106(3):232-238
pubmed: 31754762
Trends Cardiovasc Med. 2001 Apr-May;11(3-4):155-61
pubmed: 11686006
Curr Drug Targets. 2020;21(3):213-227
pubmed: 31433756
Arch Osteoporos. 2022 Aug 12;17(1):112
pubmed: 35960383
Clin Chem. 2004 Oct;50(10):1725-32
pubmed: 15308601
BMC Endocr Disord. 2023 Aug 3;23(1):162
pubmed: 37537589
BMC Musculoskelet Disord. 2023 Mar 2;24(1):157
pubmed: 36864426
Can J Diabetes. 2022 Feb;46(1):3-9.e3
pubmed: 34053878
Medicine (Baltimore). 2019 Jul;98(27):e16096
pubmed: 31277108
Lancet. 2019 Jan 26;393(10169):364-376
pubmed: 30696576
Endocrine. 2022 Dec;78(3):587-596
pubmed: 36044108
Endocr Rev. 2000 Apr;21(2):115-37
pubmed: 10782361
Bone. 2019 Oct;127:37-43
pubmed: 31158506
Korean J Fam Med. 2012 May;33(3):166-73
pubmed: 22787539
Eur Rev Med Pharmacol Sci. 2018 Jan;22(1):1-9
pubmed: 29364465
Aging Clin Exp Res. 2023 Jun;35(6):1273-1281
pubmed: 37186209
BMC Musculoskelet Disord. 2023 Mar 22;24(1):213
pubmed: 36949432
Front Endocrinol (Lausanne). 2022 Jul 05;13:922903
pubmed: 35865310
J Clin Endocrinol Metab. 2021 Jun 16;106(7):e2613-e2621
pubmed: 33735391
Clin Nutr. 2018 Dec;37(6 Pt A):2137-2143
pubmed: 29089152
Arch Osteoporos. 2019 Mar 9;14(1):36
pubmed: 30852689
Curr Opin Lipidol. 2021 Aug 1;32(4):226-230
pubmed: 33870931
J Endocrinol Invest. 2005;28(10 Suppl):69-72
pubmed: 16550727
Biol Trace Elem Res. 2023 Sep;201(9):4254-4261
pubmed: 36508128
BMC Musculoskelet Disord. 2021 Sep 6;22(1):759
pubmed: 34488720
Sci Rep. 2022 Jun 10;12(1):9597
pubmed: 35688870
JAMA Cardiol. 2019 Dec 1;4(12):1287-1295
pubmed: 31642874
Front Public Health. 2023 Jan 06;10:1032550
pubmed: 36684980
Eur Rev Med Pharmacol Sci. 2022 Apr;26(8):2755-2764
pubmed: 35503620
JAMA Cardiol. 2022 Mar 01;7(3):250-256
pubmed: 34773460
PLoS One. 2019 Feb 22;14(2):e0212464
pubmed: 30794634
J Orthop Surg Res. 2022 Feb 15;17(1):92
pubmed: 35168655
J Bone Metab. 2022 May;29(2):123-131
pubmed: 35718929
PLoS One. 2017 Dec 7;12(12):e0189168
pubmed: 29216254
Bone. 2010 Apr;46(4):1011-5
pubmed: 20045497
Arch Osteoporos. 2021 Jun 24;16(1):100
pubmed: 34169345
Semin Cell Dev Biol. 2022 Mar;123:14-21
pubmed: 34024716