Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer.
Humans
Female
Tubulin Modulators
/ pharmacology
Tubulin
/ metabolism
Poly(ADP-ribose) Polymerase Inhibitors
/ pharmacology
Cell Line, Tumor
Drug Screening Assays, Antitumor
Antineoplastic Agents
/ pharmacology
Apoptosis
Endometrial Neoplasms
/ drug therapy
Flavones
/ pharmacology
Benzopyrans
Cell Proliferation
Flavone
PARP
benzopyran
endometrial cancer
inhibitor
tubulin
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
medline:
6
11
2023
pubmed:
3
11
2023
entrez:
3
11
2023
Statut:
ppublish
Résumé
Structural tailoring of the flavone framework (position 7) via organopalladium-catalyzed C-C bond formation was attempted in this study. The impact of substituents with varied electronic effects (phenyl ring, position 2 of the benzopyran scaffold) on the antitumor properties was also assessed. Resultantly, the efforts yielded a furyl arm bearing benzopyran possessing a 4-fluoro phenyl ring (position 2) (
Identifiants
pubmed: 37919954
doi: 10.1080/14756366.2023.2276665
pmc: PMC10627047
doi:
Substances chimiques
Tubulin Modulators
0
Tubulin
0
Poly(ADP-ribose) Polymerase Inhibitors
0
Antineoplastic Agents
0
Flavones
0
Benzopyrans
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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