Temperature modulates PVN pre-sympathetic neurones via transient receptor potential ion channels.

PVH PVN TRPV4 computational model hypothalamus ion channel patch clamp thermoregulation

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2023
Historique:
received: 11 07 2023
accepted: 03 10 2023
medline: 3 11 2023
pubmed: 3 11 2023
entrez: 3 11 2023
Statut: epublish

Résumé

The paraventricular nucleus (PVN) of the hypothalamus plays a vital role in maintaining homeostasis and modulates cardiovascular function via autonomic pre-sympathetic neurones. We have previously shown that coupling between transient receptor potential cation channel subfamily V Member 4 (Trpv4) and small-conductance calcium-activated potassium channels (SK) in the PVN facilitate osmosensing, but since TRP channels are also thermosensitive, in this report we investigated the temperature sensitivity of these neurones.

Identifiants

pubmed: 37920211
doi: 10.3389/fphar.2023.1256924
pii: 1256924
pmc: PMC10618372
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1256924

Informations de copyright

Copyright © 2023 O’Brien, Feetham, Staunton, Hext and Barrett-Jolley.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Fiona O'Brien (F)

Department of Musculoskeletal Ageing Science, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.

Claire H Feetham (CH)

Department of Musculoskeletal Ageing Science, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.

Caroline A Staunton (CA)

Department of Musculoskeletal Ageing Science, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.

Kathryn Hext (K)

Department of Musculoskeletal Ageing Science, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.

Richard Barrett-Jolley (R)

Department of Musculoskeletal Ageing Science, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.

Classifications MeSH