Prenatal infection and adolescent social adversity affect microglia, synaptic density, and behavior in male rats.
Maternal immune activation
Microglia
Neurodevelopmental disorders
Social adversity
Synaptic density
Synaptophysin
Journal
Neurobiology of stress
ISSN: 2352-2895
Titre abrégé: Neurobiol Stress
Pays: United States
ID NLM: 101643409
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
31
07
2023
revised:
27
09
2023
accepted:
12
10
2023
medline:
3
11
2023
pubmed:
3
11
2023
entrez:
3
11
2023
Statut:
epublish
Résumé
Maternal infection during pregnancy and childhood social trauma have been associated with neurodevelopmental and affective disorders, such as schizophrenia, autism spectrum disorders, bipolar disorder and depression. These disorders are characterized by changes in microglial cells, which play a notable role in synaptic pruning, and synaptic deficits. Here, we investigated the effect of prenatal infection and social adversity during adolescence - either alone or in combination - on behavior, microglia, and synaptic density. Male offspring of pregnant rats injected with poly I:C, mimicking prenatal infection, were exposed to repeated social defeat during adolescence. We found that maternal infection during pregnancy prevented the reduction in social behavior and increase in anxiety induced by social adversity during adolescence. Furthermore, maternal infection and social adversity, alone or in combination, induced hyperlocomotion in adulthood. Longitudinal in vivo imaging with [
Identifiants
pubmed: 37920548
doi: 10.1016/j.ynstr.2023.100580
pii: S2352-2895(23)00068-1
pmc: PMC10618826
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100580Informations de copyright
© 2023 Published by Elsevier Inc.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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