Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis.
Journal
The New England journal of medicine
ISSN: 1533-4406
Titre abrégé: N Engl J Med
Pays: United States
ID NLM: 0255562
Informations de publication
Date de publication:
28 Dec 2023
28 Dec 2023
Historique:
medline:
2
1
2024
pubmed:
3
11
2023
entrez:
3
11
2023
Statut:
ppublish
Résumé
An unmet need exists for focal segmental glomerulosclerosis (FSGS) treatment. In an 8-week, phase 2 trial, sparsentan, a dual endothelin-angiotensin receptor antagonist, reduced proteinuria in patients with FSGS. The efficacy and safety of longer-term treatment with sparsentan for FSGS are unknown. In this phase 3 trial, we enrolled patients with FSGS (without known secondary causes) who were 8 to 75 years of age; patients were randomly assigned to receive sparsentan or irbesartan (active control) for 108 weeks. The surrogate efficacy end point assessed at the prespecified interim analysis at 36 weeks was the FSGS partial remission of proteinuria end point (defined as a urinary protein-to-creatinine ratio of ≤1.5 [with protein and creatinine both measured in grams] and a >40% reduction in the ratio from baseline). The primary efficacy end point was the estimated glomerular filtration rate (eGFR) slope at the time of the final analysis. The change in eGFR from baseline to 4 weeks after the end of treatment (week 112) was a secondary end point. Safety was also evaluated. A total of 371 patients underwent randomization: 184 were assigned to receive sparsentan and 187 to receive irbesartan. At 36 weeks, the percentage of patients with partial remission of proteinuria was 42.0% in the sparsentan group and 26.0% in the irbesartan group (P = 0.009), a response that was sustained through 108 weeks. At the time of the final analysis at week 108, there were no significant between-group differences in the eGFR slope; the between-group difference in total slope (day 1 to week 108) was 0.3 ml per minute per 1.73 m Among patients with FSGS, there were no significant between-group differences in eGFR slope at 108 weeks, despite a greater reduction in proteinuria with sparsentan than with irbesartan. (Funded by Travere Therapeutics; DUPLEX ClinicalTrials.gov number, NCT03493685.).
Sections du résumé
BACKGROUND
BACKGROUND
An unmet need exists for focal segmental glomerulosclerosis (FSGS) treatment. In an 8-week, phase 2 trial, sparsentan, a dual endothelin-angiotensin receptor antagonist, reduced proteinuria in patients with FSGS. The efficacy and safety of longer-term treatment with sparsentan for FSGS are unknown.
METHODS
METHODS
In this phase 3 trial, we enrolled patients with FSGS (without known secondary causes) who were 8 to 75 years of age; patients were randomly assigned to receive sparsentan or irbesartan (active control) for 108 weeks. The surrogate efficacy end point assessed at the prespecified interim analysis at 36 weeks was the FSGS partial remission of proteinuria end point (defined as a urinary protein-to-creatinine ratio of ≤1.5 [with protein and creatinine both measured in grams] and a >40% reduction in the ratio from baseline). The primary efficacy end point was the estimated glomerular filtration rate (eGFR) slope at the time of the final analysis. The change in eGFR from baseline to 4 weeks after the end of treatment (week 112) was a secondary end point. Safety was also evaluated.
RESULTS
RESULTS
A total of 371 patients underwent randomization: 184 were assigned to receive sparsentan and 187 to receive irbesartan. At 36 weeks, the percentage of patients with partial remission of proteinuria was 42.0% in the sparsentan group and 26.0% in the irbesartan group (P = 0.009), a response that was sustained through 108 weeks. At the time of the final analysis at week 108, there were no significant between-group differences in the eGFR slope; the between-group difference in total slope (day 1 to week 108) was 0.3 ml per minute per 1.73 m
CONCLUSIONS
CONCLUSIONS
Among patients with FSGS, there were no significant between-group differences in eGFR slope at 108 weeks, despite a greater reduction in proteinuria with sparsentan than with irbesartan. (Funded by Travere Therapeutics; DUPLEX ClinicalTrials.gov number, NCT03493685.).
Identifiants
pubmed: 37921461
doi: 10.1056/NEJMoa2308550
doi:
Substances chimiques
Biomarkers
0
Creatinine
AYI8EX34EU
Irbesartan
J0E2756Z7N
sparsentan
9242RO5URM
Banques de données
ClinicalTrials.gov
['NCT03493685']
Types de publication
Randomized Controlled Trial
Clinical Trial, Phase III
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2436-2445Investigateurs
Hernán Trimarchi
(H)
Rafael Alberto Maldonado
(RA)
Mariano Tomas Arriola
(MT)
Pablo Antonio Novoa
(PA)
María Belén Barrón
(MB)
Evelin Lilian Cassini
(EL)
Oscar Chavez Choque
(O)
Maria Paula Dionisi
(MP)
Judith Gaite
(J)
Ana Paula Giotto
(AP)
Ivan Alberto Gonzalez Hoyos
(IA)
Gaston Guzman Souto
(G)
Mauro Guillermo Lampo
(MG)
Jimena Lodolo
(J)
Fernando Lombi
(F)
Matias Monkowski
(M)
Mariana Ursino
(M)
Paul Champion de Crespigny
(P)
Chen Peh
(C)
Aron Chakera
(A)
Eswari Vilayur
(E)
Jane Holt
(J)
Nicholas Gray
(N)
David Johnson
(D)
Yan Li
(Y)
Mona Razavian
(M)
Amirhossein Aarabi
(A)
Jobert Anjelo
(J)
Tom Barbour
(T)
Neil Boudville
(N)
Michael Cai
(M)
Victoria Campbell
(V)
Scott Campbell
(S)
Shane Carney
(S)
Doris Chan
(D)
Melissa Cheetham
(M)
Hicham Cheikh Hassan
(HC)
Yeoung-Jee Cho
(YJ)
Peter Choi
(P)
Angela Chou
(A)
Bruce Cooper
(B)
Tony Elias
(T)
Magid Fahim
(M)
Randall Faull
(R)
Celine Foote
(C)
Ross Francis
(R)
Martin Gallagher
(M)
Alastair Gillies
(A)
Carmel Hawley
(C)
Lauren Heath
(L)
Daniel Hirsch
(D)
Peter Hollett
(P)
Regina Hong
(R)
Nicole Isbel
(N)
Sadia Jahan
(S)
Arunima Jain
(A)
Dana Kim
(D)
Johanna Kohlhagen
(J)
Anoushka Krishnan
(A)
Rathika Krishnasamy
(R)
Joshua Lawrence Lee
(JL)
Wai Lim
(W)
Kumaradevan Mahadevan
(K)
Amanda Mather
(A)
Thida Maung Maung Myint
(TMM)
David Mudge
(D)
Kieran Muir
(K)
Brendon Neuen
(B)
Euan Noble
(E)
Emma OLone
(E)
Elaine Phua
(E)
Samantha Putrino
(S)
Angus Ritchie
(A)
Sarah Roxburgh
(S)
Shaundeep Sen
(S)
Yvonne Shen
(Y)
Amanda Siriwardana
(A)
Stefanie Stangenberg
(S)
Sven-Jean Tan
(SJ)
Nigel Toussaint
(N)
Jeffrey Tsun Kit Ha
(JTK)
Carolyn VanEps
(C)
Susan Wan
(S)
Amanda Wang
(A)
Jane Waugh
(J)
Roger Wyndham
(R)
Chii Yeap
(C)
Bart Maes
(B)
Xavier Warling
(X)
Bjorn Meijers
(B)
Laurent Weekers
(L)
Katrien De Vusser
(K)
Jean-Marie Krzesinski
(JM)
Thomas Malfait
(T)
Catherine Masset
(C)
Martina Milicevic
(M)
Martial Moonen
(M)
Luc Radermacher
(L)
Amaryllis Van Craenenbroeck
(A)
An Vanacker
(A)
Fabiana Piovesan
(F)
Francisco Veronese
(F)
Irene L Noronha
(IL)
Lucila Maria Valente
(LM)
Gianna M Kirsztajn
(GM)
Marcella Soares Laferreira
(M)
Jose Hermogenes Rocco Suassuna
(JHR)
Vanessa Dos Santos Silva
(V)
Laila Almeida Viana
(LA)
Elvino Barros
(E)
Luis Henrique Bezerra Cavalcanti Sette
(LH)
Cristiane Bitencourt Dias
(C)
Sabrina Bonvino Polycarpo
(S)
Luiz Fernando de Souza
(LF)
Renato Demarchi Foresto
(RD)
Denise Maria do Nascimento Costa
(DMDN)
Guilherme Dorigo
(G)
Pamela Falbo Dos Reis
(P)
Samirah Gomes
(S)
Maria Alina Gomes de Mattos Cavalcante
(MA)
Marilia Guimaraes
(M)
Jorge Luiz De Carvalho Henriques Junior
(JL)
Cristina Karohl
(C)
Ivens Stuart Lima Leite
(IS)
Camila Barbosa Lyra de Oliveira
(CBL)
Juliana Mansur Siliano
(J)
Helomar Neto
(H)
Vanessa Oliveira Gomes
(V)
Marcelo Pereira da Silva
(M)
Milena Pozzatto Rodrigues
(M)
Carlos Prompt
(C)
Conrado Lysandro Rodrigues Gomes
(CL)
Péricles Sarturi
(P)
Luana Raposo Soares
(L)
Hélio Tedesco Silva Júnior
(H)
Fernando Thome
(F)
Glaucia Tres
(G)
Gisele Vajgel Fernandes
(GV)
Veronica Verleine Horbe Antunes
(VVH)
Alan McMahon
(A)
Matthew Weir
(M)
Serge Cournoyer
(S)
Susan Huang
(S)
Khaled Lotfy
(K)
George Soltys
(G)
Bojan Jelakovic
(B)
Djuro Plavljanic
(D)
Ingrid Prkacin
(I)
Dunja Barisic
(D)
Zivka Dika
(Z)
Lana Gellineo
(L)
Sandra Karanovic
(S)
Mario Laganovic
(M)
Karolina Majstorovic Barac
(K)
Ivana Mikacic
(I)
Marija Stankovic
(M)
Dubravka Trajbar Kentric
(D)
Vaclava Honova
(V)
Ivan Rychlik
(I)
Vladimir Tesar
(V)
Anna Benesova
(A)
Klara Drinovska
(K)
Karolina Kratka
(K)
Anna Marsakova
(A)
Nikola Mejzlikova
(N)
Zuzana Zajacova
(Z)
Oskar Zakiyanov
(O)
Per Ivarsen
(P)
Anne Daugaard Thuesen
(A)
Marie Kjaergaard
(M)
Krista Kjaergaard
(K)
Kenneth Nielsen
(K)
Gudrun Steffensen
(G)
Johan Vestergaard Povlsen
(J)
Mai Rosenberg
(M)
Madis Ilmoja
(M)
Kulli Kolvald
(K)
Elviira Seppet
(E)
Kadri Telling
(K)
Kristin Unt
(K)
Kristi Veermae
(K)
Claire Rigothier
(C)
Cyril Garrouste
(C)
Eric Alamartine
(E)
Eric Thervet
(E)
Stephane Burtey
(S)
Philippe Zaoui
(P)
Evangeline Pillebout
(E)
Vincent Esnault
(V)
Bertrand Knebelmann
(B)
Dominique Chauveau
(D)
Claire Cartery
(C)
Imad Abboud
(I)
Marine Andreani
(M)
Julien Aniort
(J)
Julie Belliere
(J)
Anne Blanchard
(A)
Noemie Chiche-Jourde
(N)
Guillaume Claisse
(G)
Christian Combe
(C)
Myriam Dao
(M)
Valérie de Précigout
(V)
Alexandra Delion
(A)
Yahsou Delmas
(Y)
Clémence Deville
(C)
Miriana Dinic
(M)
Bertrand Dussol
(B)
Stanislas Faguer
(S)
Antoine Fayol
(A)
Dominique Fleury
(D)
David Fouassier
(D)
Marine Freist
(M)
Alienor Galinier
(A)
Denis Glotz
(D)
Marlene Goubet
(M)
Mary Jane Guerry
(MJ)
Anne-Elisabeth Heng
(AE)
Marie-Flore Hennino
(MF)
Antoine Huart
(A)
Alexandre Karras
(A)
Carmen Lefaucheur
(C)
Marine Livrozet
(M)
Aurélien Lorthioir
(A)
Nicolas Maillard
(N)
Nathalie Maisonneuve
(N)
Christophe Mariat
(C)
Ingrid Masson
(I)
Hesham Mohey
(H)
Marie-Nöelle Peraldi
(MN)
Carole Philipponnet
(C)
Daniele Pievani
(D)
David Ribes
(D)
Stephane Roueff
(S)
Barbara Seitz Polski
(B)
Aude Servais
(A)
Damien Thibaudin
(D)
Marc Ulrich
(M)
Cyrille Vandenbussche
(C)
Denis Viglietti
(D)
Markus Ketteler
(M)
Thilo Krueger
(T)
Markus van der Giet
(M)
Marcus Moeller
(M)
Diliana Draganova
(D)
Hermann Haller
(H)
Adrian Schreiber
(A)
Martina Bertolo
(M)
Juergen Floege
(J)
Christopher Gohlisch
(C)
Sven Heinrichs
(S)
Bernd Hohenstein
(B)
Mikai Hsiao
(M)
Jessica Kaufeld
(J)
Nadine Koch
(N)
Jens Kruth
(J)
Simone Kulka
(S)
Uta Kunter
(U)
Svjetlana Lovric
(S)
Pascal Panzer
(P)
Anastasia Paulmann
(A)
Helmut Reichel
(H)
Alexander Reshetnik
(A)
Silja Sanden
(S)
Sebahat Sat
(S)
Moritz Schanz
(M)
Severin Schricker
(S)
Evelyn Seelow
(E)
Eleni Stamellou
(E)
Simone van der Giet
(S)
Sibylle von Vietinghoff
(S)
Lea Weiland
(L)
Thomas Weinreich
(T)
Lothar Wolf
(L)
Sydney Chi Wai Tang
(SCW)
Ka Shun Samuel Fung
(KSS)
Gary Chi Wang Chan
(GCW)
Anthony Ting Pong Chan
(ATP)
Lorraine Pui Yuen Kwan
(LPY)
Kit Ming Lee
(KM)
Davina Ngoi Wah Lie
(DNW)
Mingyao Ma
(M)
Benjamin So
(B)
Hon Tang
(H)
Federico Pieruzzi
(F)
Ciro Esposito
(C)
Stefano Costanzi
(S)
Loreto Gesualdo
(L)
Giovanni Montini
(G)
Calogero Lino Cirami
(CL)
Francesca Viazzi
(F)
Giuseppe Remuzzi
(G)
Selena Longhi
(S)
Mirco Belingheri
(M)
Nicolino Comi
(N)
Giovanni Gambaro
(G)
Gaetano La Manna
(G)
Valeria Aiello
(V)
Marco Allinovi
(M)
Martina Ambrogio
(M)
Maria Arena
(M)
Rocco Baccaro
(R)
Olga Baraldi
(O)
Simona Barbuto
(S)
Matteo Bargagli
(M)
Giulia Benizzelli
(G)
Grazia Dea Bonelli
(GD)
Monica Bordoli
(M)
Flavia Capaccio
(F)
Leonardo Caroti
(L)
Nazareno Carullo
(N)
Davide Catucci
(D)
Sara Cavagnaro
(S)
Andrea Cavalli
(A)
Marina Elena Cazzaniga
(ME)
Nunzia Ciferri
(N)
Calogero Cirami
(C)
Marco Colucci
(M)
Elisa Costa
(E)
Erica Daina
(E)
Francesca Deodato
(F)
Egrina Dervishi
(E)
Vittoria Esposito
(V)
Concetta Gangemi
(C)
Luciana Ghio
(L)
Iacopo Gianassi
(I)
Marica Giliberti
(M)
Monica Limardo
(M)
Lucia Maccio
(L)
William Morello
(W)
Patrizia Passerini
(P)
Gemma Patella
(G)
Vittoria Pavone
(V)
Norberto Perico
(N)
Lohengrin Pirillo
(L)
Lucia Pisano
(L)
Luisa Ricciato
(L)
Barbara Ruggiero
(B)
Elisa Russo
(E)
Michela Saio
(M)
Tiziana Stellato
(T)
Massimo Torreggiani
(M)
Matias Trillini
(M)
Mirsa Turhani
(M)
Paolo Vercelloni
(P)
Sara Vigano
(S)
Denise Zerega
(D)
Dong Ki Kim
(DK)
Jong Cheol Jeong
(JC)
Yeong Hoon Kim
(YH)
Seung Hyeok Han
(SH)
Sung-Gyun Kim
(SG)
Ki Ryang Na
(KR)
Dae Eun Choi
(DE)
Seung Seok Han
(SS)
Kwon-Wook Joo
(KW)
Yong Chul Kim
(YC)
TaeHee Kim
(T)
Yunmi Kim
(Y)
Hajeong Lee
(H)
Hyung-Seok Lee
(HS)
Kang Wook Lee
(KW)
Jung Tak Park
(JT)
Young Rim Song
(YR)
Tae-Hyun Yoo
(TH)
Kannaiyan Rabindranath
(K)
Tze Goh
(T)
Jafar Ahmed
(J)
Lai Wan Chan
(LW)
Ian Dittmer
(I)
Andrew Henderson
(A)
Helen Pilmore
(H)
Peter Sizeland
(P)
Eddie Tan
(E)
Angus Turnbull
(A)
Gerald Waters
(G)
Magdalena Krajewska
(M)
Robert Malecki
(R)
Marcin Tkaczyk
(M)
Norbert Kwella
(N)
Anna Masajtis Zagajewska
(A)
Tomasz Stompor
(T)
Michal Ciszek
(M)
Hanna Augustyniak-Bartosik
(H)
Elzbieta Felicjanczuk
(E)
Iwona Filipska
(I)
Julita Gontarek-Kacprzak
(J)
Anna Jander
(A)
Ewa Kalecinska-Krystkiewicz
(E)
Monika Krajewska
(M)
Bogna Kwella
(B)
Ewa Satora
(E)
Malgorzata Stanczyk
(M)
Agata Winiarska
(A)
Justyna Zbrzezniak
(J)
Dorota Zielinska
(D)
Sofia Jorge
(S)
Bruno Rodrigues
(B)
Ana Farinha
(A)
Fernando Nolasco
(F)
Ana Marta Gomes
(AM)
Ana Cortesão Costa
(A)
Manuel Pestana
(M)
Ana Rita Mateus Martins
(AR)
Catarina Abrantes
(C)
Catarina Tavares de Almedia
(C)
Edgar Almeida
(E)
Patricia Alves
(P)
Rui Barata
(R)
Patricia Branco
(P)
Pedro Campos
(P)
Filipa Cardoso
(F)
Jose Nuno de Almeida Agapito Fonseca
(JN)
Jose Carlos de Jesus Barreto
(JC)
Luis Pedro Falcao Goncalves
(LPF)
João Carlos Fernandes
(JC)
Sara Fernandes
(S)
Adriana Fernandes
(A)
Filipa Ferreira
(F)
Nuno Fonseca
(N)
Teresa Furtado
(T)
Joana Gameiro
(J)
Mario Gois
(M)
Sara Goncalves
(S)
Daniela Lopes
(D)
Catarina Marouco
(C)
Joana Marques
(J)
Ana Catarina Mateus
(AC)
Luis Mendonca
(L)
Maria Menezes
(M)
Ana Messias
(A)
Ana Natario
(A)
Ana Teresa Nunes
(AT)
Carolina Ormonde
(C)
Lucia Parreira
(L)
Luciano Artur Pereira
(LA)
Elsa Sofia Quadrado Soares
(ES)
Mario Raimundo
(M)
Marina Reis
(M)
Ana Catarina Rodrigues Bras
(AC)
Sónia Silva
(S)
Jose Silvano
(J)
Joana de Sousa Soares Felgueiras
(J)
Helena Sousa
(H)
Luis Sousa
(L)
Catarina Teixeira
(C)
Patricia Valerio Santos
(PV)
Alvaro Vaz
(A)
Rita Verissimo
(R)
Secundino Cigarran Guldris
(S)
Tamara Malek Marin
(T)
Maria Antonia Munar Vila
(MA)
Javier Nieto Iglesias
(J)
Ana Huerta Arroyo
(A)
Elena Gutierrez Solis
(E)
Eva Rodriguez Garcia
(E)
Ana Avila Bernabeu
(A)
Mercedes Salgueira Lazo
(M)
Montserrat Diaz Encarnacion
(M)
Luis F Quintana
(LF)
Irene Agraz Pamplona
(I)
Antonio Galan Serrano
(A)
Alberto Ortiz Arduan
(A)
Eduardo Parra Moncasi
(E)
Mercedes Velo Plaza
(M)
Mario Espinoa Hernandez
(M)
Victor Lopez-Baez
(V)
Miguel Angel Perez Valdivia
(MA)
Candela Moliz
(C)
Candido Diaz Rodriguez
(C)
Wenceslao Adrian Aguilera Morales
(WA)
Natalia Allende Burgos
(N)
Fabiola Alonso Garcia
(F)
Sara Anaya Fernandez
(SA)
Immaculada Ansio Vazquez
(I)
Sara Aparicio Peris
(S)
Carlos Arias
(C)
Maria Antonieta Azancot Rivero
(MA)
Jose Ballarin
(J)
Clara Barrios
(C)
Josep Miquel Blasco Pelicano
(JM)
Ivon Maritza Bobadilla Rico
(IM)
Carla Burballa Tarrega
(C)
Emma Calatayud Aristoy
(E)
Marta Calvo Arevalo
(M)
Iara Da Silva Santos
(I)
Francisco de la Prada Alvarez
(F)
Manuel Pereira de Vicente
(M)
Raul Fernandez Prado
(R)
Manuel Fidalgo Diaz
(M)
Clara Garcia Carro
(C)
Maria Garcia Murias
(M)
Mercedes Gonzalez Moya
(M)
Olga Gracia Garcia
(O)
Carmen Grande Cabrerizo
(C)
Pilar Hidalgo Guzman
(P)
Isabel Lopez Lopez
(I)
Helena Marco Rusinol
(H)
Eva Marquez Mosquera
(E)
Maria Dolores Martinez Esteban
(MD)
Caridad Martinez Villanueva
(C)
Cristina Medrano Villarroya
(C)
Evangelina Merida Herrero
(E)
Ana Munoz Sanchez
(A)
Angel Palacios Castillo
(A)
Jonay Pantoja Perez
(J)
Maria Victoria Pendon Ruiz de Mier
(MV)
María Vanessa Pérez Gómez
(MV)
Leticia Perez Luna
(L)
Salia Virxinia Pol Heres
(SVP)
Jose Mª Portoles Perez
(JM)
Juan Carlos Primo Alvarez
(JC)
Cristina Rabasco Ruiz
(C)
Natalia Ramos Terrades
(N)
Jose Luis Rocha Castilla
(JL)
Lida Maria Rodas Marin
(LM)
Antolina Rodríguez
(A)
Maria Dolores Sánchez de la Nieta
(MD)
Mari Sargsyan
(M)
Angel Sevillano
(A)
Adriana Sierra Ochoa
(A)
Eugenia Sola Moyano
(E)
Alejandro Soria Villen
(A)
Esther Tamarit
(E)
Remedios Toledo
(R)
Ana Vilar Gimeno
(AV)
Belen Vizcaino Castillo
(B)
Annette Bruchfeld
(A)
Gregor Guron
(G)
Bengt Fellström
(B)
Lilija Supranaviciene
(L)
Asta Dögg Jonasdottir
(AD)
Hans Furuland
(H)
Olof Heimbürger
(O)
Jan Melin
(J)
Aso Saeed
(A)
Hsien-Yi Wang
(HY)
Bang-Gee Hsu
(BG)
Ming-Ju Wu
(MJ)
Chih-Jen Wu
(CJ)
Chiu-Ching Huang
(CC)
Mai-Szu Wu
(MS)
Hua-Chang Fang
(HC)
Yung-Ho Hsu
(YH)
Kuan-Hsing Chen
(KH)
Yung-Ming Chen
(YM)
Chih-Hsiang Chang
(CH)
Cheng-Hsu Chen
(CH)
Hsi-Hsien Chen
(HH)
Hsin-Yu Chen
(HY)
Chien-Liang Chen
(CL)
Yu-Wei Chen
(YW)
Wen-Chih Chiang
(WC)
Chih-Chiang Chien
(CC)
I-Jen Chiu
(IJ)
Ji-Tseng Fang
(JT)
Chih-Yang Hsu
(CY)
Chun-Te Huang
(CT)
Chien-Wei Huang
(CW)
Tao-Min Huang
(TM)
Lie-Yee Hung
(LY)
Ming-Yan Jiang
(MY)
Wei-Chih Kan
(WC)
Chih-Chin Kao
(CC)
Huey-Liang Kuo
(HL)
Pei-Chun Lai
(PC)
Yu-Hsien Lai
(YH)
Ping-Chin Lai
(PC)
Tai-Shuan Lai
(TS)
Po-Tsang Lee
(PT)
Yi-Jung Li
(YJ)
Cheng-Jui Lin
(CJ)
Hsin-Hung Lin
(HH)
Yen-Chung Lin
(YC)
Shuei-Liong Lin
(SL)
Chi-Feng Pan
(CF)
Hong-Mou Shih
(HM)
Ya-Chung Tian
(YC)
Shang-Feng Tsai
(SF)
Kun-Hua Tu
(KH)
Chih-Hsien Wang
(CH)
I-Kuan Wang
(IK)
Jie-Sian Wang
(JS)
Chia-Chun Wu
(CC)
Pei-Chen Wu
(PC)
Yueh-Lin Wu
(YL)
Mei-Yi Wu
(MY)
Vin-Cent Wu
(VC)
Ya-Fei Yang
(YF)
Huang-Yu Yang
(HY)
Shao-Yu Yang
(SY)
Cai-Mei Zheng
(CM)
Jonathan Barratt
(J)
Sui Kon
(S)
Smeeta Sinha
(S)
Kieran McCafferty
(K)
Ruth Pepper
(R)
Durga Kanigicherla
(D)
Laurence Solomon
(L)
Ashraf Mikhail
(A)
Mona Wahba
(M)
Sarah Lawman
(S)
Bassam Alchi
(B)
Sian Griffin
(S)
John Sayer
(J)
Colin Jones
(C)
Lisa Willcocks
(L)
Mohamed Alhadj Ali
(M)
Michelle Allan
(M)
Georgios Athanasios Loumpardias
(G)
Jonathan Ayling-Smith
(J)
Christian Brix
(C)
Karen Brown
(K)
Thomas Bucknall
(T)
Chee Kay Cheung
(CK)
Constantina Chrysochou
(C)
Chukwuma Chukwu
(C)
Louise DaSilva
(L)
Aine Marie De Bhailis
(AM)
Oliver Flossmann
(O)
David Green
(D)
Patrick Hamilton
(P)
Francesca Hogan
(F)
Amy Hudson
(A)
Rachel Jones
(R)
Kostos Koutroutsos
(K)
Andreas Kronbichler
(A)
Farah Latif
(F)
Rachel Lennon
(R)
Ian Logan
(I)
Nathan Lorde
(N)
Ian Macdougall
(I)
Eamon Mahdi
(E)
Sandip Mitra
(S)
Hiba Mohamed
(H)
Rebekah Molyneux
(R)
Emma Montgomery
(E)
Adam Morris
(A)
Arvind Ponnusamy
(A)
Hei Man Priscilla Chan
(HMP)
Omar Ragy
(O)
Mohammad Rony
(M)
Haresh Selvaskandan
(H)
Sapna Shah
(S)
Priscilla Smith
(P)
Subash Somalanka
(S)
Joshua Storrar
(J)
Victoria Ware
(V)
Olivia Wickens
(O)
Sioned Williams
(S)
Sharon Adler
(S)
Ahmed Awad
(A)
Kirk Campbell
(K)
Carolyn Abitbol
(C)
Katherine Dell
(K)
Vimal Derebail
(V)
Alessia Fornoni
(A)
Michael Germain
(M)
Siddhartha Kattamanchi
(S)
Laura Malaga-Dieguez
(L)
Faisal Fakih
(F)
Pascale Lane
(P)
Kenneth Lieberman
(K)
Howard Lifland
(H)
Sankar Navaneethan
(S)
Laura Ann Kooienga
(LA)
Ellen McCarthy
(E)
Carlos Mercado
(C)
Kevin Meyers
(K)
Lawrence Milner
(L)
Sungchun Lee
(S)
Abanti Chaudhuri
(A)
Ana Paredes
(A)
Jusmin Patel
(J)
Pietro Canetta
(P)
Michelle N Rheault
(MN)
Rebecca Schmidt
(R)
Pamela Singer
(P)
Tarak Srivastava
(T)
Harold Szerlip
(H)
Juan Velez
(J)
Gaia Coppock
(G)
Cybele Ghossein
(C)
Antonio Guasch
(A)
Elizabeth Brown
(E)
Gregory Greenwood
(G)
Adhish Agarwal
(A)
Mandeep Sahani
(M)
German Hernandez
(G)
Carlos Araya
(C)
Lisa Rich
(L)
Asghar Chaudhry
(A)
Bruce Spinowitz
(B)
Isabelle Ayoub
(I)
Saravanan Balamuthusamy
(S)
Patrick Gipson
(P)
Arnold Silva
(A)
Bruce Baker
(B)
Viet Nguyen
(V)
James Tumlin
(J)
Dennis Ross
(D)
Mindy Banks
(M)
Katherine Tuttle
(K)
Amy Becker
(A)
Pascal Dabel
(P)
Olayiwola Ayodeji
(O)
Marwan Kaskas
(M)
Rohit Pankhaniya
(R)
Kaushal Patel
(K)
Aamir Jamal
(A)
Richard Odonovan
(R)
Dawn Caster
(D)
Sumit Kumar
(S)
Sreedhar Mandayam
(S)
Wai Lang Lau
(WL)
Caroline Gluck
(C)
Nelson Kopyt
(N)
Elaine Kamil
(E)
Juan A Fernandez
(JA)
Ali Poyan Mehr
(A)
Sanjiv Anand
(S)
Neil Kumar
(N)
Vinod Prasad
(V)
Mark Faber
(M)
Wayne Kotzker
(W)
Amit Johnsingh
(A)
Michael Casey
(M)
Venkat Chitumalla
(V)
Fernando Fervenza
(F)
Thomas Peter
(T)
Jonathan Tolins
(J)
Rasheed Gbadegesin
(R)
Mark Vishnepolsky
(M)
Scott Wenderfer
(S)
Frederick Kaskel
(F)
Jay Shankar
(J)
Suneel Udani
(S)
Marva Moxey-Mims
(M)
Chike Okechukwu
(C)
Michael Moritz
(M)
Wooin Ahn
(W)
Manohar Ahuja
(M)
Adeem Akbar
(A)
Sana Akbar
(S)
Irme Akhtar
(I)
Akinwande Akinfolarin
(A)
Theresa Alexander
(T)
Radica Alicic
(R)
Salem Almaani
(S)
Laith Al-Rabadi
(L)
Gloria Alvarado
(G)
Kamal Amin
(K)
Melissa Anslow
(M)
Nkeekam Anumele
(N)
Gerald Appel
(G)
Michael Archie
(M)
Sarah Ashley Ford Sightler
(SA)
Natasha Atkinson
(N)
Asha Bailey
(A)
Mallory Barker
(M)
Arnold Barz
(A)
Nitin Bhasin
(N)
Michael Bien
(M)
Laura Blalock
(L)
Mary Blanton
(M)
Andrew Bomback
(A)
Kenneth Boren
(K)
Raed Bou Matar
(RB)
Helen Brickel
(H)
Jose Burgos
(J)
Christine Burke
(C)
Matthew Butoryak
(M)
Melissa Cadnapaphornchai
(M)
Jenna Camacho
(J)
Juan Carbonell
(J)
Cristina Casias
(C)
Rosalie Castaneda
(R)
Laura Juliana Castellano Reyes
(LJ)
Vimal Chadha
(V)
Chaim Charytan
(C)
Vibha Chauhan
(V)
Ian Chiu
(I)
Cheng Chu
(C)
Annabelle Chua
(A)
Laurie Clark
(L)
Shannon Clark
(S)
Nisha Clement
(N)
Brittany Cleveland
(B)
Sharon Collins
(S)
Jeffrey Connaire
(J)
Gabriel Contreras
(G)
Olivera Marsenic Couloures
(O)
Jessica Curley
(J)
Tiane Dai
(T)
Cheryl Dalton
(C)
Robert Davidson
(R)
Lisa Davis
(L)
Dalia M Dawoud
(DM)
Sachin Desai
(S)
Soni Dhanireddy
(S)
Ranjit Dhelaria
(R)
Anas Diab
(A)
James Dilley
(J)
David Drew
(D)
Yelena Drexler
(Y)
Parham Eftekhari
(P)
Mireille El Ters
(M)
Amanda Emmrich
(A)
Leigh Ettinger
(L)
Paul Fadakar
(P)
Aaron Fearday
(A)
Eric Fels
(E)
Victor Fernandez
(V)
Frederick Fleszler
(F)
Anna Gaden
(A)
Rajdeep Gadh
(R)
Sandra Gaiser
(S)
Claudio Gallego
(C)
Philip Garavaglia
(P)
Gunjan Garg
(G)
Jyothsna Gattineni
(J)
Abdallah Geara
(A)
Salam Gharaybeh
(S)
Keisha Gibson
(K)
Debbie Gipson
(D)
Nayan Gowda
(N)
Barbara Greco
(B)
Heather Green
(H)
Aditi Gupta
(A)
Alexander Hadley
(A)
Jehad Haggiagi
(J)
Amanda Hall
(A)
Michael Hand
(M)
Stephanie Hanzl
(S)
Charles Hare
(C)
Erum Hartung
(E)
Elizabeth Hendren
(E)
Lawrence Holzman
(L)
Billy Hour
(B)
Yon Hyuk Kwon
(YH)
Miki Ilaw
(M)
Ruth Indahyung
(R)
Srinivasa Iskapalli
(S)
Vidya Iyer
(V)
Radu Jacob
(R)
Halima Janjua
(H)
Antonio Jimenez
(A)
Guillermo Jimenez
(G)
Tracy Jonelis
(T)
Jennifer Jones
(J)
Praveena Jyothinagaram
(P)
Shaun Kaiser
(S)
Dinesh Kannabhiran
(D)
Subbian Karumanchi
(S)
Kianoosh Kaveh
(K)
Christopher Keller
(C)
Muhammad Khan
(M)
Sarah Kizilbash
(S)
Prashant Kolar
(P)
Oleksandr Kovalchuk
(O)
Sanjeev Kumar
(S)
Damodar Kumbala
(D)
Sheng Kuo
(S)
Clarles Kwon
(C)
Anh La
(A)
Mark Lagatta
(M)
Suresh Lakshminarayanan
(S)
Jessica Lapasia
(J)
Christopher LaRosa
(C)
Greg Larsen
(G)
Benjamin Laskin
(B)
Michael Lattanzio
(M)
Denise Laurienti
(D)
Matthew Law
(M)
Brenda Le
(B)
Frederick Lee
(F)
Carlos Leon-Forero
(C)
Catherine Lorentz
(C)
Peggy Ann Lugo
(PA)
Ivo Lukitsch
(I)
Shuaike Ma
(S)
Karen MacKay
(K)
Ahmed Malik
(A)
Sandhya Manohar
(S)
Roy Marcus
(R)
Laura Mariani
(L)
Jacob Maris
(J)
Christopher Marshall
(C)
Nicholas McLean
(N)
Allyson Medina
(A)
Ankit Mehta
(A)
Kristin Meliambro
(K)
Jerry Meng
(J)
Joan Milton
(J)
Yosuke Miyashita
(Y)
Mojtaba Moghadam
(M)
Jorge Enrique Monroy Avella
(JE)
Brenda Montane
(B)
Amy Mottl
(A)
Asha Moudgil
(A)
Michael Mudry
(M)
Deepak Nandikanti
(D)
Javier Narvarte
(J)
Anjali Nayak
(A)
Mitzi Near
(M)
Bradley Nelson
(B)
Britt Newsome
(B)
Julie Nicoletta
(J)
Izuchukwu Nwakoby
(I)
Rosemary Nwoko
(R)
Naima Ogletree
(N)
Andrew Olafsson
(A)
Olanrewaju Olaoye
(O)
Andrea Oliverio
(A)
Rebecca Ong
(R)
John O'Toole
(J)
Abhijeet Pal
(A)
Samir Parikh
(S)
Anthony Parravani
(A)
Andrew Patchett
(A)
Surju Patel
(S)
Meera Patel Suthar
(M)
William Paxton
(W)
Bethany Pellegrino
(B)
Lazara Perez
(L)
Usha Peri
(U)
Helen Pizzo
(H)
Mark Poling
(M)
Thomas Powell
(T)
Roopashree Prabhushankar
(R)
Dechu Puliyanda
(D)
Robert Quigley
(R)
Sarah Quinn
(S)
Ritesh Raichoudhury
(R)
Ranganathan Rajendran
(R)
Maya Rao
(M)
Altaf Rasool
(A)
David Rath
(D)
Matthew Reed
(M)
Kimberly Reidy
(K)
Rosemary Reriani
(R)
David Reynolds
(D)
Syed Rizvi
(S)
Abid Rizvi
(A)
Alfred Rodriguez
(A)
Mariselis Rosa-Sanchez
(M)
Jason Rothschild
(J)
Brad Rovin
(B)
Mario Ruiz
(M)
Scott Satko
(S)
John Sedor
(J)
Wacharee Seeherunvong
(W)
Melvin Seek
(M)
Kirenia Segura
(K)
David Selewski
(D)
Christine Sethna
(C)
Imran Shafique
(I)
Shweta Shah
(S)
Shuchita Sharma
(S)
Elaine Shirley
(E)
Sahar Siddiqui
(S)
Joanne Siu
(J)
Sunil Skaria
(S)
Brian Snow
(B)
Vinay Srinivasan
(V)
James Sullivan
(J)
Irina Suyumova
(I)
Sudhir Thaduri
(S)
Schawana Thaxton
(S)
Theodore Thomas
(T)
Dawn Thomas
(D)
Luis Torres
(L)
Kevin Tucker
(K)
Kausik Umanath
(K)
Mahesh Vaghela
(M)
Cindy Vanhoy
(C)
Javier Vasallo
(J)
Himanshu Vashistha
(H)
Sailaja Ventrapragada
(S)
Ricardo Viera
(R)
Shikha Wadhwani
(S)
Carl Walther
(C)
Lisa Weber
(L)
Melissa Weitzel
(M)
Larysa Wickman
(L)
Karen Wilder
(K)
Karen Williams
(K)
Christopher Che Dar Wong
(CCD)
Lawrence Wong
(L)
Biruh Workeneh
(B)
Zachary Yablon
(Z)
Oscar Yee
(O)
Andrew Yue
(A)
Raja Zabaneh
(R)
Hui Zhao
(H)
Mohamed Zidan
(M)
Vlado Perkovic
(V)
Charles E Alpers
(CE)
Stewart Bieler
(S)
Hiddo J L Heerspink
(HJL)
Jonathan Hogan
(J)
Alex Mercer
(A)
Jai Radhakrishnan
(J)
Howard Trachtman
(H)
Muh Geot Wong
(MG)
Laurence Greenbaum
(L)
Chuck Davis
(C)
Mitchell Rosner
(M)
William B White
(WB)
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2023 Massachusetts Medical Society.